| UniProt ID | VIRF1_HHV8P | |
|---|---|---|
| UniProt AC | F5HF68 | |
| Protein Name | VIRF-1 | |
| Gene Name | vIRF-1 | |
| Organism | Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus). | |
| Sequence Length | 449 | |
| Subcellular Localization | ||
| Protein Description | Plays a role in the inhibition of host innate response by repressing the expression of interferon-inducible genes and blocking host IRF1- and IRF3-mediated transcription. Blocks the interaction between host IRF3 and CREBBP.. | |
| Protein Sequence | MDPGQRPNPFGAPGAIPKKPCLSQGSPGTSGSGAPCDEPSRSESPGEGPSGTGGSAAAGDITRQAVVAAITEWSRTRQLRISTGASEGKASIKDWIVCQVNSGKFPGVEWEDEERTRFRIPVTPLADPCFEWRRDGELGVVYIRERGNMPVDASFKGTRGRRRMLAALRRTRGLQEIGKGISQDGHHFLVFRVRKPEEEQCVECGVVAGAVHDFNNMARLLQEGFFSPGQCLPGEIVTPVPSCTTAEGQEAVIDWGRLFIRMYYNGEQVHELLTTSQSGCRISSALRRDPAVHYCAVGSPGQVWLPNVPNLACEIAKRELCDTLDACAKGILLTSSCNGIFCVCYHNGPVHFIGNTVPPDSGPLLLPQGKPTRIFNPNTFLVGLANSPLPAPSHVTCPLVKLWLGKPVAVGKLEPHAPSPRDFAARCSNFSDACVVLEIMPKPLWDAMQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of VIRF1_HHV8P !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VIRF1_HHV8P !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VIRF1_HHV8P !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VIRF1_HHV8P !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CBP_HUMAN | CREBBP | physical | 22810585 | |
| EP300_HUMAN | EP300 | physical | 22810585 | |
| IRF3_HUMAN | IRF3 | physical | 11314014 | |
| IRF7_HUMAN | IRF7 | physical | 11314014 | |
| IRF1_HUMAN | IRF1 | physical | 10438822 | |
| VIRF2_HHV8P | vIRF-2 | physical | 10438822 | |
| EP300_HUMAN | EP300 | physical | 10438822 | |
| UBP7_HUMAN | USP7 | physical | 26786098 | |
| HERC5_HUMAN | HERC5 | physical | 26355087 | |
| EP300_HUMAN | EP300 | physical | 26355087 | |
| CBP_HUMAN | CREBBP | physical | 26355087 | |
| ENKD1_HUMAN | ENKD1 | physical | 25544563 | |
| EP300_HUMAN | EP300 | physical | 25544563 | |
| PAWR_HUMAN | PAWR | physical | 25544563 | |
| CBP_HUMAN | CREBBP | physical | 25544563 | |
| RBL1_HUMAN | RBL1 | physical | 25544563 | |
| SDC2_HUMAN | SDC2 | physical | 25544563 | |
| RB_HUMAN | RB1 | physical | 25544563 | |
| RL3L_HUMAN | RPL3L | physical | 25544563 | |
| GPC4_HUMAN | GPC4 | physical | 25544563 | |
| TFCP2_HUMAN | TFCP2 | physical | 25544563 | |
| UBIP1_HUMAN | UBP1 | physical | 25544563 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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