HXB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXB4_HUMAN
• UniProt AC: P17483
• Protein Name: Homeobox protein Hox-B4
• Gene Name: HOXB4
• Organism: Homo sapiens (Human).
• Sequence Length: 251
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAACTVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGAAGSAGGPPGRPNGGPRAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	KFPPCEEYSQSDYLP CCCCCHHHCCCCCCC	6.96	26074081
24	Phosphorylation	FPPCEEYSQSDYLPS CCCCHHHCCCCCCCC	26.87	26074081
26	Phosphorylation	PCEEYSQSDYLPSDH CCHHHCCCCCCCCCC	23.45	26074081
28	Phosphorylation	EEYSQSDYLPSDHSP HHHCCCCCCCCCCCC	26.26	26074081
31	Phosphorylation	SQSDYLPSDHSPGYY CCCCCCCCCCCCCCC	45.41	26074081
34	Phosphorylation	DYLPSDHSPGYYAGG CCCCCCCCCCCCCCC	25.63	26074081
37	Phosphorylation	PSDHSPGYYAGGQRR CCCCCCCCCCCCCCC	8.10	26074081
38	Phosphorylation	SDHSPGYYAGGQRRE CCCCCCCCCCCCCCC	12.51	26074081
46	Phosphorylation	AGGQRRESSFQPEAG CCCCCCCCCCCCCCC	34.34	23401153
47	Phosphorylation	GGQRRESSFQPEAGF CCCCCCCCCCCCCCC	24.13	28555341
90	Phosphorylation	PPPPPGLSPRAPAPP CCCCCCCCCCCCCCC	20.46	30108239
114	Phosphorylation	GQRCEAVSSSPPPPP CCCCEECCCCCCCCC	31.95	30108239
115	Phosphorylation	QRCEAVSSSPPPPPC CCCEECCCCCCCCCC	40.02	30108239
116	Phosphorylation	RCEAVSSSPPPPPCA CCEECCCCCCCCCCC	33.64	23401153
130	Phosphorylation	AQNPLHPSPSHSACK CCCCCCCCCCCCCCC	28.43	30576142
132	Phosphorylation	NPLHPSPSHSACKEP CCCCCCCCCCCCCCC	34.12	26074081
134	Phosphorylation	LHPSPSHSACKEPVV CCCCCCCCCCCCCCC	39.43	27050516
142	Phosphorylation	ACKEPVVYPWMRKVH CCCCCCCCCCCCEEE	7.45	-
147	Ubiquitination	VVYPWMRKVHVSTVN CCCCCCCEEEEEECC	22.16	29967540
157	Phosphorylation	VSTVNPNYAGGEPKR EEECCCCCCCCCCCC	14.10	27642862
163	Ubiquitination	NYAGGEPKRSRTAYT CCCCCCCCCCCCHHH	59.72	29967540
185	Methylation	EKEFHYNRYLTRRRR HHHHHHHHHHHHHHH	22.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBX1_HUMAN	RBX1	physical	21098278
CUL4A_HUMAN	CUL4A	physical	21098278
DDB1_HUMAN	DDB1	physical	21098278

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.