HXB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXB3_HUMAN
• UniProt AC: P14651
• Protein Name: Homeobox protein Hox-B3
• Gene Name: HOXB3
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MQKATYYDNAAAALFGGYSSYPGSNGFGFDVPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLSAPPGSPPPSAAPTSATSNSSNGGGPSKSGPPKCGPGTNSTLTKQIFPWMKESRQTSKLKNNSPGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPMAPSQHHGPCEPHPTYTDLSSHHAPPPQGRIQEAPKLTHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	NAAPHAKSKELNGSC CCCCCCCCCCCCCCC	31.95	22210691
72	Phosphorylation	KSKELNGSCMRPGLA CCCCCCCCCCCCCCC	12.03	22210691
89	Phosphorylation	PLSAPPGSPPPSAAP CCCCCCCCCCCCCCC	39.75	26503514
93	Phosphorylation	PPGSPPPSAAPTSAT CCCCCCCCCCCCCCC	42.72	26503514
97	Phosphorylation	PPPSAAPTSATSNSS CCCCCCCCCCCCCCC	26.68	22210691
103	Phosphorylation	PTSATSNSSNGGGPS CCCCCCCCCCCCCCC	25.58	-
104	Phosphorylation	TSATSNSSNGGGPSK CCCCCCCCCCCCCCC	43.68	-
110	Phosphorylation	SSNGGGPSKSGPPKC CCCCCCCCCCCCCCC	42.61	22210691
121	Phosphorylation	PPKCGPGTNSTLTKQ CCCCCCCCCCHHHHH	29.18	25690035
123	Phosphorylation	KCGPGTNSTLTKQIF CCCCCCCCHHHHHHH	25.32	25690035
146	Phosphorylation	TSKLKNNSPGTAEGC CHHCCCCCCCCCCCC	33.82	22210691
149	Phosphorylation	LKNNSPGTAEGCGGG CCCCCCCCCCCCCCC	25.56	29900121
165	Phosphorylation	GGGGGGGSGGSGGGG CCCCCCCCCCCCCCC	43.16	22210691
168	Phosphorylation	GGGGSGGSGGGGGGG CCCCCCCCCCCCCCC	37.48	22210691
181	Phosphorylation	GGGGGDKSPPGSAAS CCCCCCCCCCCCHHH	40.86	23532336
185	Phosphorylation	GDKSPPGSAASKRAR CCCCCCCCHHHHHHH	26.83	23532336
188	Phosphorylation	SPPGSAASKRARTAY CCCCCHHHHHHHHHH	23.53	23532336
193	Phosphorylation	AASKRARTAYTSAQL HHHHHHHHHHHHHHH	24.03	-
254	Phosphorylation	QKAKGLASSSGGPSP HHHHHCCCCCCCCCC	30.03	27251275
255	Phosphorylation	KAKGLASSSGGPSPA HHHHCCCCCCCCCCC	27.65	27251275
256	Phosphorylation	AKGLASSSGGPSPAG HHHCCCCCCCCCCCC	45.32	27251275
260	Phosphorylation	ASSSGGPSPAGSPPQ CCCCCCCCCCCCCCC	30.56	27251275
264	Phosphorylation	GGPSPAGSPPQPMQS CCCCCCCCCCCCCCH	35.20	27251275
302	Phosphorylation	GKAHQNAYALPSNYQ CHHHCCCCCCCCCCC	19.07	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXB3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HXB3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.