PHX2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHX2B_HUMAN
• UniProt AC: Q99453
• Protein Name: Paired mesoderm homeobox protein 2B
• Gene Name: PHOX2B
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Subcellular Localization: Nucleus .
• Protein Description: Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element..
• Protein Sequence: MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	FQYNPIRTTFGATSG CCCCCCCCCCCCCCC	27.48	27732954
50	Phosphorylation	QYNPIRTTFGATSGC CCCCCCCCCCCCCCC	15.38	27732954
54	Phosphorylation	IRTTFGATSGCPSLT CCCCCCCCCCCCCCC	26.49	27732954
55	Phosphorylation	RTTFGATSGCPSLTP CCCCCCCCCCCCCCC	37.55	27732954
59	Phosphorylation	GATSGCPSLTPGSCS CCCCCCCCCCCCCCE	49.29	27732954
61	Phosphorylation	TSGCPSLTPGSCSLG CCCCCCCCCCCCEEC	29.91	27732954
64	Phosphorylation	CPSLTPGSCSLGTLR CCCCCCCCCEECCCC	11.18	27732954
66	Phosphorylation	SLTPGSCSLGTLRDH CCCCCCCEECCCCCC	31.37	27732954
69	Phosphorylation	PGSCSLGTLRDHQSS CCCCEECCCCCCCCC	24.74	27732954
75	Phosphorylation	GTLRDHQSSPYAAVP CCCCCCCCCCCEECC	29.84	27732954
76	Phosphorylation	TLRDHQSSPYAAVPY CCCCCCCCCCEECCH	18.50	27732954
78	Phosphorylation	RDHQSSPYAAVPYKL CCCCCCCCEECCHHH	14.78	25884760
83	Phosphorylation	SPYAAVPYKLFTDHG CCCEECCHHHHCCCC	17.45	30177828
84	Ubiquitination	PYAAVPYKLFTDHGG CCEECCHHHHCCCCC	30.93	23503661
87	Phosphorylation	AVPYKLFTDHGGLNE ECCHHHHCCCCCCCH	37.21	-
95	Ubiquitination	DHGGLNEKRKQRRIR CCCCCCHHHHHHHHH	64.92	23503661
97	Ubiquitination	GGLNEKRKQRRIRTT CCCCHHHHHHHHHHH	60.26	23503661
111	Ubiquitination	TFTSAQLKELERVFA HHCHHHHHHHHHHHH	48.44	23503661
152	Ubiquitination	WFQNRRAKFRKQERA HHHCHHHHHHHHHHH	43.84	23503661
155	Ubiquitination	NRRAKFRKQERAAAA CHHHHHHHHHHHHHH	60.69	23503661
155	Acetylation	NRRAKFRKQERAAAA CHHHHHHHHHHHHHH	60.69	21466224
168	Ubiquitination	AAAAAAAKNGSSGKK HHHHHHHHHCCCCCC	58.05	23503661
171	Phosphorylation	AAAAKNGSSGKKSDS HHHHHHCCCCCCCCC	45.36	-
172	Phosphorylation	AAAKNGSSGKKSDSS HHHHHCCCCCCCCCC	56.90	-
174	Ubiquitination	AKNGSSGKKSDSSRD HHHCCCCCCCCCCCC	51.56	23503661
176	Phosphorylation	NGSSGKKSDSSRDDE HCCCCCCCCCCCCCH	46.33	-
205	Phosphorylation	PGPNPNPTPSCGANG CCCCCCCCCCCCCCC	34.18	30177828
207	Phosphorylation	PNPNPTPSCGANGGG CCCCCCCCCCCCCCC	27.88	30177828
219	Phosphorylation	GGGGGGPSPAGAPGA CCCCCCCCCCCCCCC	30.56	30177828

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHX2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHX2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHX2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBP_HUMAN	CREBBP	physical	19191321

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.