PPR3F_HUMAN - dbPTM
PPR3F_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPR3F_HUMAN
UniProt AC Q6ZSY5
Protein Name Protein phosphatase 1 regulatory subunit 3F
Gene Name PPP1R3F
Organism Homo sapiens (Human).
Sequence Length 799
Subcellular Localization Membrane
Single-pass membrane protein.
Protein Description Glycogen-targeting subunit for protein phosphatase 1 (PP1)..
Protein Sequence MARTAPVEPPLRHSAPPSPAAGEPRTSVEAAVAPRRVLFADEALGLPLAQLRRYRPWGGPGAGKMAAAAGQDGGGGGGADEDDDGEDGDEGEEEEEACPEPSPLCPVPAGGGFYLVPTFSLPPAPGRLERLGRVMVELEALLPPPGAVPGGAGVWVPGGRPPVLRGLVRVLNRSFEKAVHVRASHDGWASFCDHPARYVPRSPPWAGAGGTGAGDPILDPGLGLGPGQASASSPDDGGRTDRFAFQLPFAEGAGDGARLDFVVRYETPEGTFWANNHGRNYTVLLRIAPAPTPTDAEGLPQQQQLPQLEPQPECQGPVEAEARQLKSCMKPVRRRPAEEELKTKNMDDNTFAMAEHPDVQESVGPLVAPTPLRPWPQMTLQVSDVPMTGNPAEEGDVPRSSPPVAFTEVLQAPAIRIPPSSPLCGLGGSPRDQASGPDASEGATGPFLEPSQQQAEATWGVSSENGGGLEAVSGSEELLGEDTIDQELEQLYLSHLSRLRAAVAAGGAGGGGEGSTDGGMSPSHPLGILTDRDLILKWPGPERALNSALAEEITLHYARLGRGVELIKDTEDPDDEGEGEEGLSVTPSSPEGDSPKESPPEILSGARSVVATMGDVWLPWAEGSGCDGPVVLGTEGQFIGDPEKGMGKDTSSLHMNRVIAGVTESLGEAGTEAQIEVTSEWAGSLDPISGKEPASPVLLQGQNPTLLSPLGAEVCLSSVARPHVSSQDEKDAGPSLEPPKKSPTLAVPAECVCALPPQLRGPLTQTLGVLAGLVVVPVALNSGVSLLVLALCLSLAWFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Methylation-----MARTAPVEPP
-----CCCCCCCCCC		30.07115488503
4Phosphorylation----MARTAPVEPPL
----CCCCCCCCCCC		26.2730177828
12MethylationAPVEPPLRHSAPPSP
CCCCCCCCCCCCCCC		27.7381452679
14PhosphorylationVEPPLRHSAPPSPAA
CCCCCCCCCCCCCCC		35.7226055452
18PhosphorylationLRHSAPPSPAAGEPR
CCCCCCCCCCCCCCC		26.5526055452
281PhosphorylationANNHGRNYTVLLRIA
ECCCCCCEEEEEEEE		9.25-
294PhosphorylationIAPAPTPTDAEGLPQ
EECCCCCCCCCCCCH		50.7724173317
400PhosphorylationEEGDVPRSSPPVAFT
CCCCCCCCCCCCCEE		40.9227732954
400O-linked_GlycosylationEEGDVPRSSPPVAFT
CCCCCCCCCCCCCEE		40.9228657654
401PhosphorylationEGDVPRSSPPVAFTE
CCCCCCCCCCCCEEE		34.2127732954
407PhosphorylationSSPPVAFTEVLQAPA
CCCCCCEEEHHCCCC		18.5527080861
420PhosphorylationPAIRIPPSSPLCGLG
CCEECCCCCCCCCCC		38.9523312004
421PhosphorylationAIRIPPSSPLCGLGG
CEECCCCCCCCCCCC		27.8923312004
429PhosphorylationPLCGLGGSPRDQASG
CCCCCCCCHHHHCCC		18.2426270265
516PhosphorylationGGGGEGSTDGGMSPS
CCCCCCCCCCCCCCC		49.9025850435
521PhosphorylationGSTDGGMSPSHPLGI
CCCCCCCCCCCCCCE		26.9025850435
523PhosphorylationTDGGMSPSHPLGILT
CCCCCCCCCCCCEEC		30.3625850435
530PhosphorylationSHPLGILTDRDLILK
CCCCCEECCCCHHHC		27.3722210691
547PhosphorylationGPERALNSALAEEIT
CHHHHHHHHHHHHHH		26.0530266825
557PhosphorylationAEEITLHYARLGRGV
HHHHHHHHHHHCCCE		9.1327642862
584PhosphorylationGEGEEGLSVTPSSPE
CCCCCCCCCCCCCCC		34.5026471730
586PhosphorylationGEEGLSVTPSSPEGD
CCCCCCCCCCCCCCC		17.6826471730
588PhosphorylationEGLSVTPSSPEGDSP
CCCCCCCCCCCCCCC		49.5126471730
589PhosphorylationGLSVTPSSPEGDSPK
CCCCCCCCCCCCCCC		28.3326471730
594PhosphorylationPSSPEGDSPKESPPE
CCCCCCCCCCCCCHH		49.0526471730
695PhosphorylationISGKEPASPVLLQGQ
CCCCCCCCCEEECCC		26.6826074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPR3F_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPR3F_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPR3F_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PPR3F_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPR3F_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"R3F, a novel membrane-associated glycogen targeting subunit ofprotein phosphatase 1 regulates glycogen synthase in astrocytoma cellsin response to glucose and extracellular signals.";
Kelsall I.R., Voss M., Munro S., Cuthbertson D.J., Cohen P.T.;
J. Neurochem. 118:596-610(2011).
Cited for: FUNCTION, TISSUE SPECIFICITY, AND PHOSPHORYLATION AT SER-14; SER-18;SER-420 AND SER-421.

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