PITX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PITX2_HUMAN
• UniProt AC: Q99697
• Protein Name: Pituitary homeobox 2
• Gene Name: PITX2
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Subcellular Localization: Nucleus.
• Protein Description: Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity)..
• Protein Sequence: METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSPESRKEAASSKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	AAVECLFSKDSEIKK HHHHHHHCCCCCCCE	23.70	24719451
38	Phosphorylation	EIKKVEFTDSPESRK CCCEEEECCCHHHHH	23.28	29255136
40	Phosphorylation	KKVEFTDSPESRKEA CEEEECCCHHHHHHH	27.75	29255136
43	Phosphorylation	EFTDSPESRKEAASS EECCCHHHHHHHHHC	52.62	29255136
58 (in isoform 2)	Phosphorylation	-	34.94	29523821
60 (in isoform 2)	Phosphorylation	-	26.01	29523821
62 (in isoform 2)	Phosphorylation	-	63.20	20363803
63 (in isoform 2)	Phosphorylation	-	70.98	20363803
64 (in isoform 2)	Phosphorylation	-	50.05	20363803
90	Phosphorylation	KRQRRQRTHFTSQQL HHHHHHHHHCCHHHH	17.01	-
94	Phosphorylation	RQRTHFTSQQLQELE HHHHHCCHHHHHHHH	18.26	28555341
190	Phosphorylation	GLTSASLSTKSFPFF CCCCCCCCCCCCCCC	31.15	22210691
280	Phosphorylation	YRDTCNSSLASLRLK CCCCCCCCHHHHHHH	17.60	23186163
283	Phosphorylation	TCNSSLASLRLKAKQ CCCCCHHHHHHHHHC	21.22	26434776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
90	T	Phosphorylation	Kinase	AKT2	P31751	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
90	T	Phosphorylation	Phosphorylation at Thr-90 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PITX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PITX2_HUMAN	PITX2	physical	11763998
MSX2_HUMAN	MSX2	genetic	11763998
PITX2_HUMAN	PITX2	physical	9685346
TRI25_HUMAN	TRIM25	physical	20211142
ZNHI3_HUMAN	ZNHIT3	physical	20211142
HDAC1_HUMAN	HDAC1	physical	12464179
CTNB1_HUMAN	CTNNB1	physical	12464179
WDR5_HUMAN	WDR5	physical	21531708
LEF1_HUMAN	LEF1	physical	15728254
SAHH3_HUMAN	AHCYL2	physical	26186194
SAHH2_HUMAN	AHCYL1	physical	26186194
LRC46_HUMAN	LRRC46	physical	26186194
CTNB1_HUMAN	CTNNB1	physical	25241761
SAHH3_HUMAN	AHCYL2	physical	28514442
LRC46_HUMAN	LRRC46	physical	28514442
SAHH2_HUMAN	AHCYL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.