LRC46_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC46_HUMAN
• UniProt AC: Q96FV0
• Protein Name: Leucine-rich repeat-containing protein 46
• Gene Name: LRRC46
• Organism: Homo sapiens (Human).
• Sequence Length: 321
• Protein Sequence: MSGGKSAQGPEEGGVCITEALITKRNLTFPEDGELSEKMFHTLDELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLAGNQIRQVENLLDLPCLQFLDLSENLIETLKLDEFPQSLLILNLSGNSCTNQDGYRELVTEALPLLLDLDGQPVVERWISDEEDEASSDEEFPELSGPFCSERGFLKELEQELSRHREHRQQTALTEHLLRMEMQPTLTDLPLLPGVPMAGDSSPSATPAQGEETVPEAVSSPQASSPTKKPCSLIPRGHQSSFWGRKGARAATAPKASVAEAPSTTKTTAKRSKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	ITEALITKRNLTFPE EEEHHHCCCCCCCCC	32.09	29967540
42	Phosphorylation	LSEKMFHTLDELQTV CCHHHCCCHHHHHHH	25.33	27794612
72	Phosphorylation	LQNLHSLYLQGNKIQ HHHHHHHHHCCCCCH	10.45	22817900
89	Phosphorylation	ENLACIPSLRFLSLA HHHHCCCHHHHHHHC	16.56	24719451
175	Phosphorylation	PVVERWISDEEDEAS EEEEEECCCCCCCCC	31.82	-
182	Phosphorylation	SDEEDEASSDEEFPE CCCCCCCCCCCCCHH	35.95	-
299	Phosphorylation	RKGARAATAPKASVA CCCCCCCCCCCCHHH	42.37	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC46_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC46_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC46_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PACS2_HUMAN	PACS2	physical	26186194
ECHB_HUMAN	HADHB	physical	26186194
RRP7A_HUMAN	RRP7A	physical	26186194
DPOE1_HUMAN	POLE	physical	26186194
OSBP1_HUMAN	OSBP	physical	26186194
TYK2_HUMAN	TYK2	physical	26186194
HJURP_HUMAN	HJURP	physical	26186194
FZR1_HUMAN	FZR1	physical	26186194
DPOE2_HUMAN	POLE2	physical	26186194
WDR37_HUMAN	WDR37	physical	26186194
UQCC1_HUMAN	UQCC1	physical	26186194
SIX4_HUMAN	SIX4	physical	26186194
AMZ2_HUMAN	AMZ2	physical	26186194
PLCD3_HUMAN	PLCD3	physical	26186194
TBP_HUMAN	TBP	physical	26186194
CCD12_HUMAN	CCDC12	physical	26186194
TFPT_HUMAN	TFPT	physical	26186194
IN80E_HUMAN	INO80E	physical	26186194
LRSM1_HUMAN	LRSAM1	physical	26186194
PACS2_HUMAN	PACS2	physical	28514442
WDR37_HUMAN	WDR37	physical	28514442
SIX4_HUMAN	SIX4	physical	28514442
TFPT_HUMAN	TFPT	physical	28514442
LRSM1_HUMAN	LRSAM1	physical	28514442
PLCD3_HUMAN	PLCD3	physical	28514442
TYK2_HUMAN	TYK2	physical	28514442
FZR1_HUMAN	FZR1	physical	28514442
RRP7A_HUMAN	RRP7A	physical	28514442
TBP_HUMAN	TBP	physical	28514442
DPOE2_HUMAN	POLE2	physical	28514442
UQCC1_HUMAN	UQCC1	physical	28514442
OSBP1_HUMAN	OSBP	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
DPOE1_HUMAN	POLE	physical	28514442
AMZ2_HUMAN	AMZ2	physical	28514442
ECHB_HUMAN	HADHB	physical	28514442
HJURP_HUMAN	HJURP	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.