AP4B1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP4B1_HUMAN
• UniProt AC: Q9Y6B7
• Protein Name: AP-4 complex subunit beta-1 {ECO:0000305}
• Gene Name: AP4B1 {ECO:0000312|HGNC:HGNC:572}
• Organism: Homo sapiens (Human).
• Sequence Length: 739
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein .
• Protein Description: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. [PubMed: 10066790]
• Protein Sequence: MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPLIPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETLNSFISVLETVIGTIEEIKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	LGSEDVVKELKKALC CCCHHHHHHHHHHHC	58.12	-
39	Phosphorylation	VIQRVIRYMTQGLDM HHHHHHHHHHCCCCC	8.06	-
71	Phosphorylation	QKKLVYLYMCTYAPL HHHHHHHHHHHCCCC	3.42	18083107
74	Phosphorylation	LVYLYMCTYAPLKPD HHHHHHHHCCCCCHH	13.24	-
89	Phosphorylation	LALLAINTLCKDCSD HHHHHHHHHCCCCCC	27.67	-
116	Ubiquitination	MCSLRMPGVQEYIQQ HHHCCCCCHHHHHHH	25.13	21906983
197	Ubiquitination	EGGVVINKPIAHHLL CCCEECCHHHHHHHH	27.03	-
209	Ubiquitination	HLLNRMSKLDQWGQA HHHHHHHHCCHHHHH	46.90	21906983
242	Phosphorylation	DILNLLDSFLKSSSP HHHHHHHHHHHCCCC	32.23	24719451
278	Malonylation	TDVLVRVKGPLLAAC CCEEEEECCCHHHHC	44.22	26320211
278	Ubiquitination	TDVLVRVKGPLLAAC CCEEEEECCCHHHHC	44.22	-
306	Phosphorylation	HVRQILHSLPGHFSS HHHHHHHHCCCCCCH	32.58	-
317	Malonylation	HFSSHYKKFFCSYSE CCCHHHHHHCCCCCC	36.18	32601280
465	Ubiquitination	EDFVENVKSETFPAV HHHHHHHHCCCCHHH	54.90	21906983
473	Ubiquitination	SETFPAVKMELLTAL CCCCHHHHHHHHHHH	28.85	-
530	Ubiquitination	LVGIDEVKRILCSPK HHCHHHHHHHHCCCC	31.51	21906983
537	Ubiquitination	KRILCSPKSDPTLGL HHHHCCCCCCCCCCC	51.72	-
558	Phosphorylation	RPVNSWASDFNTLVP CCCCCHHHCCCCCCC	36.15	27259358
567	Phosphorylation	FNTLVPVYGKAHWAT CCCCCCCCCCCHHHH	13.57	27259358
569	Ubiquitination	TLVPVYGKAHWATIS CCCCCCCCCHHHHHH	21.28	-
577	Ubiquitination	AHWATISKCQGAERC CHHHHHHHCCCCCCC	27.08	-
590	Ubiquitination	RCDPELPKTSSFAAS CCCCCCCCCCCCCCC	73.91	-
591	Phosphorylation	CDPELPKTSSFAASG CCCCCCCCCCCCCCC	27.88	26657352
592	Phosphorylation	DPELPKTSSFAASGP CCCCCCCCCCCCCCC	29.59	26657352
593	Phosphorylation	PELPKTSSFAASGPL CCCCCCCCCCCCCCC	24.92	25159151
597	Phosphorylation	KTSSFAASGPLIPEE CCCCCCCCCCCCCHH	37.20	21815630
606	Ubiquitination	PLIPEENKERVQELP CCCCHHHHHHHHHCC	50.61	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP4B1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP4B1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP4B1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP4E1_HUMAN	AP4E1	physical	10436028
AP4M1_HUMAN	AP4M1	physical	10436028
ZN576_HUMAN	ZNF576	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614066: Cerebral palsy, spastic quadriplegic 5 (CPSQ5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.