ZBT22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT22_HUMAN
• UniProt AC: O15209
• Protein Name: Zinc finger and BTB domain-containing protein 22
• Gene Name: ZBTB22
• Organism: Homo sapiens (Human).
• Sequence Length: 634
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTITTAAATSVTVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIMPQKHWVYVKRGGNCPAPTPLVPQDPDLEEEEEEEDLVLTCEDDEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPVAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAEHGAVTVGGTSVGSLGVPGSVGGVPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERRHRLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVEMGFGGGGGAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	EPSPLSPSGAALPLP CCCCCCCCCCCCCCC	37.37	-
78	Phosphorylation	HRAVLAASSPYFHDQ HHHHHHHCCCCCHHH	26.66	24719451
81	Phosphorylation	VLAASSPYFHDQVLL HHHHCCCCCHHHHHH	18.59	22210691
92	Phosphorylation	QVLLKGMTSISLPSV HHHHCCCCCCCCCCC	31.42	22210691
95	Phosphorylation	LKGMTSISLPSVMDP HCCCCCCCCCCCCCC	33.71	22210691
153	Phosphorylation	LLREGRASATTTITT HHHCCCCCCEEEEEE	25.45	25022875
155	Phosphorylation	REGRASATTTITTAA HCCCCCCEEEEEEEC	23.21	25022875
156	Phosphorylation	EGRASATTTITTAAA CCCCCCEEEEEEECC	18.87	25022875
157	Phosphorylation	GRASATTTITTAAAT CCCCCEEEEEEECCC	16.39	25022875
159	Phosphorylation	ASATTTITTAAATSV CCCEEEEEEECCCEE	14.32	25022875
160	Phosphorylation	SATTTITTAAATSVT CCEEEEEEECCCEEE	15.50	25022875
164	Phosphorylation	TITTAAATSVTVPGA EEEEECCCEEEECCC	21.00	25022875
165	Phosphorylation	ITTAAATSVTVPGAG EEEECCCEEEECCCC	15.86	25022875
167	Phosphorylation	TAAATSVTVPGAGVP EECCCEEEECCCCCC	22.28	25022875
175	Phosphorylation	VPGAGVPSGSGGTVA ECCCCCCCCCCCCCC	43.09	25022875
177	Phosphorylation	GAGVPSGSGGTVAPA CCCCCCCCCCCCCCC	38.09	25022875
180	Phosphorylation	VPSGSGGTVAPATMG CCCCCCCCCCCCCHH	19.61	25022875
185	Phosphorylation	GGTVAPATMGSARSH CCCCCCCCHHHHHHH	22.47	25022875
188	Phosphorylation	VAPATMGSARSHASS CCCCCHHHHHHHHHH	15.08	25022875
191	Phosphorylation	ATMGSARSHASSRAS CCHHHHHHHHHHHCC	24.11	25022875
194	Phosphorylation	GSARSHASSRASENQ HHHHHHHHHHCCCCC	18.22	25022875
195	Phosphorylation	SARSHASSRASENQS HHHHHHHHHCCCCCC	32.42	25022875
198	Phosphorylation	SHASSRASENQSPSS HHHHHHCCCCCCCCC	35.65	30108239
202	Phosphorylation	SRASENQSPSSSNYF HHCCCCCCCCCCCCC	38.03	28102081
204	Phosphorylation	ASENQSPSSSNYFSP CCCCCCCCCCCCCCC	52.20	30576142
205	Phosphorylation	SENQSPSSSNYFSPR CCCCCCCCCCCCCCC	26.45	28450419
206	Phosphorylation	ENQSPSSSNYFSPRE CCCCCCCCCCCCCCC	39.63	27732954
208	Phosphorylation	QSPSSSNYFSPREST CCCCCCCCCCCCCCC	13.84	27732954
215	Phosphorylation	YFSPRESTDFSSSSQ CCCCCCCCCCCCCHH	35.99	30576142
220	Phosphorylation	ESTDFSSSSQEAFAA CCCCCCCCHHHHHHH	34.54	27251275
221	Phosphorylation	STDFSSSSQEAFAAS CCCCCCCHHHHHHHH	33.71	28985074
236	Methylation	AVGSGERRGGGPVFP HHCCCCCCCCCCCCC	43.75	115920309
355	Phosphorylation	VGGGPEATLSISDVR CCCCCCCEEEHHHCE	21.26	-
555	Phosphorylation	KKFMWRDSFMRHRGH CHHHHHHHHHHHCCH	16.62	26074081
580	Phosphorylation	GAVPGPGTPTGPSLP CCCCCCCCCCCCCCC	22.32	27251275
582	Phosphorylation	VPGPGTPTGPSLPSK CCCCCCCCCCCCCCC	62.66	25954137
585	Phosphorylation	PGTPTGPSLPSKRES CCCCCCCCCCCCCCC	55.01	-
588	Phosphorylation	PTGPSLPSKRESPGV CCCCCCCCCCCCCCC	50.03	25954137
592	Phosphorylation	SLPSKRESPGVGGGS CCCCCCCCCCCCCCC	30.87	20363803
599	Phosphorylation	SPGVGGGSGDEASAA CCCCCCCCCCHHHCC	46.47	29255136
604	Phosphorylation	GGSGDEASAATPPSS CCCCCHHHCCCCCCC	19.18	29255136
607	Phosphorylation	GDEASAATPPSSRRV CCHHHCCCCCCCCCC	35.13	28450419
610	Phosphorylation	ASAATPPSSRRVWSP HHCCCCCCCCCCCCC	37.37	24275569
616	Phosphorylation	PSSRRVWSPPRVHKV CCCCCCCCCCEEEEE	23.36	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL4_HUMAN	UBQLN4	physical	16169070
FXR2_HUMAN	FXR2	physical	25416956
RBM39_HUMAN	RBM39	physical	25416956
MCRS1_HUMAN	MCRS1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.