COMD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COMD8_HUMAN
• UniProt AC: Q9NX08
• Protein Name: COMM domain-containing protein 8
• Gene Name: COMMD8
• Organism: Homo sapiens (Human).
• Sequence Length: 183
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. [PubMed: 21778237 May down-regulate activation of NF-kappa-B]
• Protein Sequence: MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEPEEGTPLWRLQK -CCCCCCCCCCHHCC	20.63	20068231
14	Ubiquitination	TPLWRLQKLPAELGP CCCCHHCCCCHHHCH	62.11	29967540
52	Sulfoxidation	VWESEEWMHVLEDIA HHCCHHHHHHHHHHH	1.45	30846556
68	Ubiquitination	FFKAIVGKNLPDEEI HHHHHHCCCCCHHHH	44.40	29967540
92	Ubiquitination	LHQETIMKCVKSRKD HCHHHHHHHHHCCHH	31.83	29967540
102	Ubiquitination	KSRKDEIKQALSREI HCCHHHHHHHHHHHH	27.72	24816145
130	Ubiquitination	QVKLALSSDKIAALR HHHHHHCCCHHHHHH	43.72	21890473
132	Ubiquitination	KLALSSDKIAALRMP HHHHCCCHHHHHHHH	35.87	23000965
132	2-Hydroxyisobutyrylation	KLALSSDKIAALRMP HHHHCCCHHHHHHHH	35.87	-
132	Acetylation	KLALSSDKIAALRMP HHHHCCCHHHHHHHH	35.87	25953088
152	Ubiquitination	LDVKENGEVKPYSIE EEECCCCEECCEEEE	59.97	29967540
154	Ubiquitination	VKENGEVKPYSIEMS ECCCCEECCEEEEEC	33.66	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COMD8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COMD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COMD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COMD3_HUMAN	COMMD3	physical	21900206
AK1C1_HUMAN	AKR1C1	physical	21900206
TMX2_HUMAN	TMX2	physical	21900206
COMD1_HUMAN	COMMD1	physical	15799966
TF65_HUMAN	RELA	physical	15799966
RELB_HUMAN	RELB	physical	15799966
NFKB1_HUMAN	NFKB1	physical	15799966
COMDA_HUMAN	COMMD10	physical	22939629
CUL1_HUMAN	CUL1	physical	23563313
CUL3_HUMAN	CUL3	physical	23563313
COMD5_HUMAN	COMMD5	physical	26344197
COMD4_HUMAN	COMMD4	physical	28514442
COMD3_HUMAN	COMMD3	physical	28514442
FA45A_HUMAN	FAM45A	physical	28514442
COMD5_HUMAN	COMMD5	physical	28514442
CCD93_HUMAN	CCDC93	physical	28514442
UIMC1_HUMAN	UIMC1	physical	28514442
COMD9_HUMAN	COMMD9	physical	28514442
DSCR3_HUMAN	DSCR3	physical	28514442
COMD7_HUMAN	COMMD7	physical	28514442
COMD2_HUMAN	COMMD2	physical	28514442
CP062_HUMAN	C16orf62	physical	28514442
CCD22_HUMAN	CCDC22	physical	28514442
QSER1_HUMAN	QSER1	physical	28514442
E2F6_HUMAN	E2F6	physical	28514442
TFDP2_HUMAN	TFDP2	physical	28514442
COG3_HUMAN	COG3	physical	28514442
TFDP1_HUMAN	TFDP1	physical	28514442
COG1_HUMAN	COG1	physical	28514442
COG8_HUMAN	COG8	physical	28514442
COG7_HUMAN	COG7	physical	28514442
COG2_HUMAN	COG2	physical	28514442
COG6_HUMAN	COG6	physical	28514442
COG5_HUMAN	COG5	physical	28514442
ATP9A_HUMAN	ATP9A	physical	28514442
BOLA1_HUMAN	BOLA1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
COG4_HUMAN	COG4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.