AK1C1_HUMAN - dbPTM
AK1C1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AK1C1_HUMAN
UniProt AC Q04828
Protein Name Aldo-keto reductase family 1 member C1
Gene Name AKR1C1
Organism Homo sapiens (Human).
Sequence Length 323
Subcellular Localization Cytoplasm.
Protein Description Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation..
Protein Sequence MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Sumoylation----MDSKYQCVKLN
----CCCCCEEEECC		34.77-
4Acetylation----MDSKYQCVKLN
----CCCCCEEEECC		34.77-
4Sumoylation----MDSKYQCVKLN
----CCCCCEEEECC		34.77-
4Ubiquitination----MDSKYQCVKLN
----CCCCCEEEECC		34.7729901268
5Phosphorylation---MDSKYQCVKLND
---CCCCCEEEECCC		15.8883941
9SumoylationDSKYQCVKLNDGHFM
CCCCEEEECCCCCEE		49.55-
9UbiquitinationDSKYQCVKLNDGHFM
CCCCEEEECCCCCEE		49.5533845483
23PhosphorylationMPVLGFGTYAPAEVP
EEEECEECCCCCCCC		17.7826356563
24PhosphorylationPVLGFGTYAPAEVPK
EEECEECCCCCCCCH		15.8027259358
31UbiquitinationYAPAEVPKSKALEAT
CCCCCCCHHHHHHHH		70.5329901268
32PhosphorylationAPAEVPKSKALEATK
CCCCCCHHHHHHHHH		19.6628857561
33UbiquitinationPAEVPKSKALEATKL
CCCCCHHHHHHHHHH		64.2233845483
38PhosphorylationKSKALEATKLAIEAG
HHHHHHHHHHHHHHC		19.7428857561
39UbiquitinationSKALEATKLAIEAGF
HHHHHHHHHHHHHCC		42.8633845483
51PhosphorylationAGFRHIDSAHLYNNE
HCCCEEEECCCCCCH		19.58110744505
55PhosphorylationHIDSAHLYNNEEQVG
EEEECCCCCCHHHHH		13.1826356563
67PhosphorylationQVGLAIRSKIADGSV
HHHHHHHHHCCCCCC		23.46-
68UbiquitinationVGLAIRSKIADGSVK
HHHHHHHHCCCCCCC		31.8733845483
73PhosphorylationRSKIADGSVKREDIF
HHHCCCCCCCHHHHE		25.6428857561
75UbiquitinationKIADGSVKREDIFYT
HCCCCCCCHHHHEEE		52.3324816145
75SumoylationKIADGSVKREDIFYT
HCCCCCCCHHHHEEE		52.33-
75SumoylationKIADGSVKREDIFYT
HCCCCCCCHHHHEEE		52.33-
75AcetylationKIADGSVKREDIFYT
HCCCCCCCHHHHEEE		52.3324771081
81PhosphorylationVKREDIFYTSKLWCN
CCHHHHEEECEEECC		15.5071943
82PhosphorylationKREDIFYTSKLWCNS
CHHHHEEECEEECCC		14.5027251275
83PhosphorylationREDIFYTSKLWCNSH
HHHHEEECEEECCCC		17.8622617229
84UbiquitinationEDIFYTSKLWCNSHR
HHHEEECEEECCCCC		37.9029967540
104SumoylationPALERSLKNLQLDYV
HHHHHHHHHCCCCEE		57.78-
104UbiquitinationPALERSLKNLQLDYV
HHHHHHHHHCCCCEE		57.7833845483
110PhosphorylationLKNLQLDYVDLYLIH
HHHCCCCEEEEEEEE		12.40119565
123UbiquitinationIHFPVSVKPGEEVIP
EECCEEECCCCCCCC		39.5433845483
131UbiquitinationPGEEVIPKDENGKIL
CCCCCCCCCCCCCEE		67.5633845483
131SumoylationPGEEVIPKDENGKIL
CCCCCCCCCCCCCEE		67.56-
141PhosphorylationNGKILFDTVDLCATW
CCCEEEEHHHHHHHH		14.4824275569
153UbiquitinationATWEAVEKCKDAGLA
HHHHHHHHHHHHCCH		39.7333845483
155UbiquitinationWEAVEKCKDAGLAKS
HHHHHHHHHHCCHHH		62.7833845483
157UbiquitinationAVEKCKDAGLAKSIG
HHHHHHHHCCHHHHC		10.6122817900
159UbiquitinationEKCKDAGLAKSIGVS
HHHHHHCCHHHHCCC		6.1022817900
161UbiquitinationCKDAGLAKSIGVSNF
HHHHCCHHHHCCCCC		47.8833845483
162PhosphorylationKDAGLAKSIGVSNFN
HHHCCHHHHCCCCCC		20.9720873877
166PhosphorylationLAKSIGVSNFNRRQL
CHHHHCCCCCCHHHH		30.4120873877
179UbiquitinationQLEMILNKPGLKYKP
HHHHHHCCCCCCCCC		36.7022817900
183UbiquitinationILNKPGLKYKPVCNQ
HHCCCCCCCCCCCCE		58.0822817900
184PhosphorylationLNKPGLKYKPVCNQV
HCCCCCCCCCCCCEE		26.1020561411
185UbiquitinationNKPGLKYKPVCNQVE
CCCCCCCCCCCCEEE		29.4122817900
196PhosphorylationNQVECHPYFNQRKLL
CEEECCCCCCHHHHH		7.4721253578
201MalonylationHPYFNQRKLLDFCKS
CCCCCHHHHHHHHCC		43.5726320211
201UbiquitinationHPYFNQRKLLDFCKS
CCCCCHHHHHHHHCC		43.5733845483
206S-palmitoylationQRKLLDFCKSKDIVL
HHHHHHHHCCCCEEE		4.9329575903
207UbiquitinationRKLLDFCKSKDIVLV
HHHHHHHCCCCEEEE		61.6129901268
208PhosphorylationKLLDFCKSKDIVLVA
HHHHHHCCCCEEEEE		36.4250564463
209UbiquitinationLLDFCKSKDIVLVAY
HHHHHCCCCEEEEEE		36.6533845483
216PhosphorylationKDIVLVAYSALGSHR
CCEEEEEECCCCCCC		6.2325867546
217PhosphorylationDIVLVAYSALGSHRE
CEEEEEECCCCCCCC		13.7925867546
221PhosphorylationVAYSALGSHREEPWV
EEECCCCCCCCCCCC		21.8825867546
232PhosphorylationEPWVDPNSPVLLEDP
CCCCCCCCCCCCCCH		23.0526657352
246UbiquitinationPVLCALAKKHKRTPA
HHHHHHHHHCCCCHH		57.1533845483
246AcetylationPVLCALAKKHKRTPA
HHHHHHHHHCCCCHH		57.1569755
247UbiquitinationVLCALAKKHKRTPAL
HHHHHHHHCCCCHHH		49.07-
247AcetylationVLCALAKKHKRTPAL
HHHHHHHHCCCCHHH		49.0719809663
270UbiquitinationRGVVVLAKSYNEQRI
CCCEEEEECCCHHHH		49.6829901268
270AcetylationRGVVVLAKSYNEQRI
CCCEEEEECCCHHHH		49.6822646283
272PhosphorylationVVVLAKSYNEQRIRQ
CEEEEECCCHHHHHH		23.24-
289PhosphorylationQVFEFQLTSEEMKAI
EEEEEECCHHHHHHH		24.2525072903
290PhosphorylationVFEFQLTSEEMKAID
EEEEECCHHHHHHHC		39.9028258704
294UbiquitinationQLTSEEMKAIDGLNR
ECCHHHHHHHCCCCC		45.5333845483
305PhosphorylationGLNRNVRYLTLDIFA
CCCCCCEEEEEEECC		10.351965335
317PhosphorylationIFAGPPNYPFSDEY-
ECCCCCCCCCCCCC-		16.071965383
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AK1C1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AK1C1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AK1C1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PTN3_HUMANPTPN3physical
25416956
AK1D1_HUMANAKR1D1physical
26186194
TFF3_HUMANTFF3physical
20499178
AK1D1_HUMANAKR1D1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00945Acetylsalicylic acid
DB00936Salicylic acid
Regulatory Network of AK1C1_HUMAN

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Related Literatures of Post-Translational Modification

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