AK1D1_HUMAN - dbPTM
AK1D1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AK1D1_HUMAN
UniProt AC P51857
Protein Name 3-oxo-5-beta-steroid 4-dehydrogenase
Gene Name AKR1D1
Organism Homo sapiens (Human).
Sequence Length 326
Subcellular Localization Cytoplasm.
Protein Description Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates..
Protein Sequence MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPFHDEY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
49PhosphorylationKVAIDTGYRHIDGAY
EEEEECCCCEECCEE		10.9146161763
56PhosphorylationYRHIDGAYIYQNEHE
CCEECCEEEECCCHH		12.9920561417
58PhosphorylationHIDGAYIYQNEHEVG
EECCEEEECCCHHHH		7.8120561425
71AcetylationVGEAIREKIAEGKVR
HHHHHHHHHHCCCCC		37.0523749302
91PhosphorylationYCGKLWATNHVPEMV
EECEEECCCCCCHHH		17.8026074081
101PhosphorylationVPEMVRPTLERTLRV
CCHHHHHHHHHHHHH		30.5926074081
105PhosphorylationVRPTLERTLRVLQLD
HHHHHHHHHHHHCCC		15.0026074081
113PhosphorylationLRVLQLDYVDLYIIE
HHHHCCCEEEEEEEE		12.4026074081
117PhosphorylationQLDYVDLYIIEVPMA
CCCEEEEEEEEECCC		8.7326074081
165PhosphorylationKDAGLVKSLGVSNFN
HHHCCHHHHCCCCCC		23.9128857561
169PhosphorylationLVKSLGVSNFNRRQL
CHHHHCCCCCCHHHH		33.6323911959
182UbiquitinationQLELILNKPGLKHKP
HHHHHHCCCCCCCCC		36.70-
199PhosphorylationNQVECHPYFTQPKLL
CCEECCCCCCCHHHH		8.8020561433
235PhosphorylationPIWVNVSSPPLLKDA
CEEEECCCCHHHHHH		26.6724275569
246PhosphorylationLKDALLNSLGKRYNK
HHHHHHHHHHHHCCC		38.1769001135
326PhosphorylationEYPFHDEY-------
CCCCCCCC-------		29.8820561441
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AK1D1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AK1D1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AK1D1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIR1_HUMANSIRT1physical
26186194
GEMI5_HUMANGEMIN5physical
26186194
PXDC2_HUMANPLXDC2physical
26186194
DIRA1_HUMANDIRAS1physical
26186194
AK1BA_HUMANAKR1B10physical
26186194
GEMI5_HUMANGEMIN5physical
28514442
DIRA1_HUMANDIRAS1physical
28514442
SIR1_HUMANSIRT1physical
28514442
AK1BA_HUMANAKR1B10physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
235555Congenital bile acid synthesis defect 2 (CBAS2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00548Azelaic Acid
DB01216Finasteride
Regulatory Network of AK1D1_HUMAN

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Related Literatures of Post-Translational Modification

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