dbPTM

TFDP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TFDP2_HUMAN
UniProt AC	Q14188
Protein Name	Transcription factor Dp-2
Gene Name	TFDP2
Organism	Homo sapiens (Human).
Sequence Length	446
Subcellular Localization	Nucleus.
Protein Description	Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters. [PubMed: 20176812]
Protein Sequence	MTAKNVGLTSTNAEVRGFIDQNLSPTKGNISFVAFPVSNTNSPTKILPKTLGPINVNVGPQMIISTPQRLTSSGSVLIGSPYTPAPAMVTQTHIAEATGWVPGDRKRARKFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFTNSNNHLAADSAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEIEKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPNSHQSSSAASHCSESRGETPCSFNDEDEEDDEEDSSSPE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTAKNVGLT ------CCCCCCCCC	46.46	22814378
2	Phosphorylation	------MTAKNVGLT ------CCCCCCCCC	46.46	24719451
4 (in isoform 2)	Phosphorylation	-	42.89	24043423
4 (in isoform 3)	Phosphorylation	-	42.89	24043423
5 (in isoform 2)	Phosphorylation	-	30.53	24043423
5 (in isoform 3)	Phosphorylation	-	30.53	24043423
9	Phosphorylation	TAKNVGLTSTNAEVR CCCCCCCCCCCHHHH	27.81	24719451
10	Phosphorylation	AKNVGLTSTNAEVRG CCCCCCCCCCHHHHC	25.38	24719451
10 (in isoform 2)	Phosphorylation	-	25.38	24043423
10 (in isoform 3)	Phosphorylation	-	25.38	24043423
11	Phosphorylation	KNVGLTSTNAEVRGF CCCCCCCCCHHHHCC	32.96	24719451
11	Ubiquitination	KNVGLTSTNAEVRGF CCCCCCCCCHHHHCC	32.96	24816145
11 (in isoform 2)	Phosphorylation	-	32.96	24043423
11 (in isoform 3)	Phosphorylation	-	32.96	24043423
12 (in isoform 2)	Phosphorylation	-	33.59	24043423
12 (in isoform 3)	Phosphorylation	-	33.59	24043423
14 (in isoform 2)	Phosphorylation	-	34.51	24043423
14 (in isoform 3)	Phosphorylation	-	34.51	24043423
19 (in isoform 2)	Phosphorylation	-	6.24	24043423
19 (in isoform 3)	Phosphorylation	-	6.24	24043423
21 (in isoform 2)	Phosphorylation	-	48.20	24043423
21 (in isoform 3)	Phosphorylation	-	48.20	24043423
22 (in isoform 2)	Phosphorylation	-	38.44	24043423
22 (in isoform 3)	Phosphorylation	-	38.44	24043423
23	Ubiquitination	RGFIDQNLSPTKGNI HCCCCCCCCCCCCCE	5.58	29967540
24	Phosphorylation	GFIDQNLSPTKGNIS CCCCCCCCCCCCCEE	37.76	19664994
26	Phosphorylation	IDQNLSPTKGNISFV CCCCCCCCCCCEEEE	48.48	30266825
27	Ubiquitination	DQNLSPTKGNISFVA CCCCCCCCCCEEEEE	54.03	24816145
29 (in isoform 2)	Phosphorylation	-	28.43	24043423
29 (in isoform 3)	Phosphorylation	-	28.43	24043423
31	Phosphorylation	SPTKGNISFVAFPVS CCCCCCEEEEEEECC	20.05	19690332
31 (in isoform 2)	Phosphorylation	-	20.05	24043423
31 (in isoform 3)	Phosphorylation	-	20.05	24043423
37 (in isoform 2)	Phosphorylation	-	5.79	24043423
37 (in isoform 3)	Phosphorylation	-	5.79	24043423
38	Phosphorylation	SFVAFPVSNTNSPTK EEEEEECCCCCCCCE	37.87	25159151
40	Phosphorylation	VAFPVSNTNSPTKIL EEEECCCCCCCCEEC	29.57	25159151
42	Phosphorylation	FPVSNTNSPTKILPK EECCCCCCCCEECCC	31.72	25159151
42 (in isoform 2)	Phosphorylation	-	31.72	24043423
42 (in isoform 3)	Phosphorylation	-	31.72	24043423
44	Phosphorylation	VSNTNSPTKILPKTL CCCCCCCCEECCCCC	30.45	25159151
45	Ubiquitination	SNTNSPTKILPKTLG CCCCCCCEECCCCCC	45.70	29967540
49	Ubiquitination	SPTKILPKTLGPINV CCCEECCCCCCCCCC	53.59	29967540
59	Ubiquitination	GPINVNVGPQMIIST CCCCCCCCCCEEEEC	11.08	29967540
63	Ubiquitination	VNVGPQMIISTPQRL CCCCCCEEEECCCEE	1.57	24816145
65	Phosphorylation	VGPQMIISTPQRLTS CCCCEEEECCCEECC	24.10	28348404
66	Phosphorylation	GPQMIISTPQRLTSS CCCEEEECCCEECCC	17.03	28348404
69	Ubiquitination	MIISTPQRLTSSGSV EEEECCCEECCCCCE	40.93	29967540
80	Phosphorylation	SGSVLIGSPYTPAPA CCCEEECCCCCCCCC	14.03	-
81	Ubiquitination	GSVLIGSPYTPAPAM CCEEECCCCCCCCCE	31.63	29967540
85	Ubiquitination	IGSPYTPAPAMVTQT ECCCCCCCCCEEEEC	9.18	29967540
88	Ubiquitination	PYTPAPAMVTQTHIA CCCCCCCEEEECHHH	3.05	29967540
92	Ubiquitination	APAMVTQTHIAEATG CCCEEEECHHHHHHC	13.09	29967540
96	Ubiquitination	VTQTHIAEATGWVPG EEECHHHHHHCCCCC	46.27	24816145
102	Ubiquitination	AEATGWVPGDRKRAR HHHHCCCCCCHHHHH	32.24	24816145
108	Ubiquitination	VPGDRKRARKFIDSD CCCCHHHHHHHHCCC	23.27	29967540
110	Ubiquitination	GDRKRARKFIDSDFS CCHHHHHHHHCCCCC	45.76	-
113	Ubiquitination	KRARKFIDSDFSESK HHHHHHHCCCCCHHH	45.33	21890473
114	Phosphorylation	RARKFIDSDFSESKR HHHHHHCCCCCHHHH	35.42	27732954
114	Ubiquitination	RARKFIDSDFSESKR HHHHHHCCCCCHHHH	35.42	29967540
117	Phosphorylation	KFIDSDFSESKRSKK HHHCCCCCHHHHCCC	46.05	30576142
118	Ubiquitination	FIDSDFSESKRSKKG HHCCCCCHHHHCCCC	61.34	29967540
119	Phosphorylation	IDSDFSESKRSKKGD HCCCCCHHHHCCCCC	31.97	21815630
120	Ubiquitination	DSDFSESKRSKKGDK CCCCCHHHHCCCCCC	57.55	29967540
122	Phosphorylation	DFSESKRSKKGDKNG CCCHHHHCCCCCCCC	42.32	7739537
124	Ubiquitination	SESKRSKKGDKNGKG CHHHHCCCCCCCCCC	73.85	24816145
127	Ubiquitination	KRSKKGDKNGKGLRH HHCCCCCCCCCCHHH	76.03	29967540
136	Phosphorylation	GKGLRHFSMKVCEKV CCCHHHHHHHHHHHH	16.15	24719451
136	Ubiquitination	GKGLRHFSMKVCEKV CCCHHHHHHHHHHHH	16.15	21890473
137	Ubiquitination	KGLRHFSMKVCEKVQ CCHHHHHHHHHHHHH	3.54	21890473
138	Ubiquitination	GLRHFSMKVCEKVQR CHHHHHHHHHHHHHH	42.40	-
142	Ubiquitination	FSMKVCEKVQRKGTT HHHHHHHHHHHHCCC	38.24	29967540
145	Ubiquitination	KVCEKVQRKGTTSYN HHHHHHHHHCCCCHH	42.21	29967540
146	Ubiquitination	VCEKVQRKGTTSYNE HHHHHHHHCCCCHHH	43.44	29967540
152	Ubiquitination	RKGTTSYNEVADELV HHCCCCHHHHHHHHH	36.71	21890473
162	Ubiquitination	ADELVSEFTNSNNHL HHHHHHHHHCCCCCC	6.45	21890473
162	Ubiquitination	ADELVSEFTNSNNHL HHHHHHHHHCCCCCC	6.45	21890473
162	Ubiquitination	ADELVSEFTNSNNHL HHHHHHHHHCCCCCC	6.45	21890473
164	Ubiquitination	ELVSEFTNSNNHLAA HHHHHHHCCCCCCCC	48.32	29967540
172 (in isoform 2)	Ubiquitination	-	28.35	21890473
173 (in isoform 3)	Ubiquitination	-	24.81	21890473
177	Ubiquitination	AADSAYDQKNIRRRV CCCCHHHHHHHHHHH	28.19	29967540
178	Ubiquitination	ADSAYDQKNIRRRVY CCCHHHHHHHHHHHH	51.98	-
185	Phosphorylation	KNIRRRVYDALNVLM HHHHHHHHHHHHHHH	8.16	25072903
188	Ubiquitination	RRRVYDALNVLMAMN HHHHHHHHHHHHHHH	4.10	21890473
188 (in isoform 4)	Ubiquitination	-	4.10	21890473
189	Ubiquitination	RRVYDALNVLMAMNI HHHHHHHHHHHHHHH	26.96	21890473
189 (in isoform 5)	Ubiquitination	-	26.96	21890473
196	Ubiquitination	NVLMAMNIISKEKKE HHHHHHHHHCCCCCC	2.12	29967540
198	Phosphorylation	LMAMNIISKEKKEIK HHHHHHHCCCCCCCE	30.85	22817900
199	Ubiquitination	MAMNIISKEKKEIKW HHHHHHCCCCCCCEE	64.24	29967540
201	Ubiquitination	MNIISKEKKEIKWIG HHHHCCCCCCCEEEE	60.48	-
202	Ubiquitination	NIISKEKKEIKWIGL HHHCCCCCCCEEEEC	66.80	29967540
205	Ubiquitination	SKEKKEIKWIGLPTN CCCCCCCEEEECCCC	33.57	29967540
221	Ubiquitination	AQECQNLEIEKQRRI HHHHHCHHHHHHHHH	57.56	21890473
224	Ubiquitination	CQNLEIEKQRRIERI HHCHHHHHHHHHHHH	55.56	29967540
227	Ubiquitination	LEIEKQRRIERIKQK HHHHHHHHHHHHHHH	32.40	21890473
228	Ubiquitination	EIEKQRRIERIKQKR HHHHHHHHHHHHHHH	4.55	21890473
238	Ubiquitination	IKQKRAQLQELLLQQ HHHHHHHHHHHHHHH	4.11	29967540
241	Ubiquitination	KRAQLQELLLQQIAF HHHHHHHHHHHHHHH	3.59	29967540
249	Ubiquitination	LLQQIAFKNLVQRNR HHHHHHHHHHHHHHH	40.11	21890473
249 (in isoform 1)	Ubiquitination	-	40.11	21890473
250	Ubiquitination	LQQIAFKNLVQRNRQ HHHHHHHHHHHHHHH	38.70	21890473
270	Phosphorylation	QGPPALNSTIQLPFI CCCCCCHHCEECCEE	27.95	24043423
271	Phosphorylation	GPPALNSTIQLPFII CCCCCHHCEECCEEE	16.21	24043423
275	Ubiquitination	LNSTIQLPFIIINTS CHHCEECCEEEEECC	11.30	29967540
278	Ubiquitination	TIQLPFIIINTSRKT CEECCEEEEECCCCE	1.71	29967540
281	Phosphorylation	LPFIIINTSRKTVID CCEEEEECCCCEEEE	21.35	24043423
282	Phosphorylation	PFIIINTSRKTVIDC CEEEEECCCCEEEEE	27.56	24043423
307	Ubiquitination	FNFDNTFEIHDDIEV EECCCCEEECCHHHH	37.06	29967540
310	Ubiquitination	DNTFEIHDDIEVLKR CCCEEECCHHHHHHH	65.33	29967540
321	Phosphorylation	VLKRMGMSFGLESGK HHHHHCCCCCCCCCC	15.50	29083192
326	Phosphorylation	GMSFGLESGKCSLED CCCCCCCCCCCCHHH	48.90	29083192
328	Ubiquitination	SFGLESGKCSLEDLK CCCCCCCCCCHHHHH	29.90	-
330	Phosphorylation	GLESGKCSLEDLKLA CCCCCCCCHHHHHHH	37.98	29083192
335	Ubiquitination	KCSLEDLKLAKSLVP CCCHHHHHHHHHHCH	59.73	29967540
338	Ubiquitination	LEDLKLAKSLVPKAL HHHHHHHHHHCHHHH	55.55	29967540
426	Phosphorylation	CSESRGETPCSFNDE CCCCCCCCCCCCCCC	32.21	30177828
429	Phosphorylation	SRGETPCSFNDEDEE CCCCCCCCCCCCCCC	28.43	30177828
442	Phosphorylation	EEDDEEDSSSPE--- CCCCCCCCCCCC---	35.68	28985074
443	Phosphorylation	EDDEEDSSSPE---- CCCCCCCCCCC----	63.33	28985074
444	Phosphorylation	DDEEDSSSPE----- CCCCCCCCCC-----	36.68	30177828

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TFDP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
24	S	Phosphorylation		23186163
Ser-24 is probably phosphorylated by CDK2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TFDP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F6_HUMAN	E2F6	physical	9704927
E2F1_HUMAN	E2F1	physical	9704927
E2F4_HUMAN	E2F4	physical	26186194
E2F5_HUMAN	E2F5	physical	26186194
RB_HUMAN	RB1	physical	26186194
E2F2_HUMAN	E2F2	physical	26186194
E2F3_HUMAN	E2F3	physical	26186194
E2F1_HUMAN	E2F1	physical	26186194
E2F2_HUMAN	E2F2	physical	28514442
E2F4_HUMAN	E2F4	physical	28514442
E2F3_HUMAN	E2F3	physical	28514442
E2F5_HUMAN	E2F5	physical	28514442
E2F1_HUMAN	E2F1	physical	28514442
RB_HUMAN	RB1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TFDP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.	19413330 [Abstract]

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