E2F3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E2F3_HUMAN
• UniProt AC: O00716
• Protein Name: Transcription factor E2F3
• Gene Name: E2F3
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Nucleus.
• Protein Description: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity)..
• Protein Sequence: MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAAAAAPGAYIQILTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALGRGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYDTSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVTYQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
121	Methylation	QQPPALGRGGSGGGG CCCCCCCCCCCCCCC	47.34	-
124	Phosphorylation	PALGRGGSGGGGGPP CCCCCCCCCCCCCCC	36.77	22817900
152	Phosphorylation	YLSDGLKTPKGKGRA HHCCCCCCCCCCCCC	34.96	29214152
163	Phosphorylation	KGRAALRSPDSPKTP CCCCCCCCCCCCCCC	33.63	25159151
166	Phosphorylation	AALRSPDSPKTPKSP CCCCCCCCCCCCCCC	31.51	25159151
168	Acetylation	LRSPDSPKTPKSPSE CCCCCCCCCCCCCCH	79.85	20167786
169	Phosphorylation	RSPDSPKTPKSPSEK CCCCCCCCCCCCCHH	39.06	25159151
171	Acetylation	PDSPKTPKSPSEKTR CCCCCCCCCCCHHHC	79.01	20167786
172	Phosphorylation	DSPKTPKSPSEKTRY CCCCCCCCCCHHHCC	34.56	25159151
174	Phosphorylation	PKTPKSPSEKTRYDT CCCCCCCCHHHCCCC	59.83	26074081
176	Acetylation	TPKSPSEKTRYDTSL CCCCCCHHHCCCCHH	42.51	60559
179	Phosphorylation	SPSEKTRYDTSLGLL CCCHHHCCCCHHHHH	28.89	30576142
181	Phosphorylation	SEKTRYDTSLGLLTK CHHHCCCCHHHHHHH	19.54	30576142
182	Phosphorylation	EKTRYDTSLGLLTKK HHHCCCCHHHHHHHH	19.97	30576142
188	Ubiquitination	TSLGLLTKKFIQLLS CHHHHHHHHHHHHHH	45.73	-
206	Ubiquitination	DGVLDLNKAAEVLKV CCCCCHHHHHHHHHH	57.16	-
212	Ubiquitination	NKAAEVLKVQKRRIY HHHHHHHHHHHHHHH	48.04	-
235	Phosphorylation	IHLIKKKSKNNVQWM HHHEECCCCCCCCEE	49.88	-
267	Phosphorylation	SKEVTELSQEEKKLD CHHHHHHHHHHHHHH	29.34	27251275
306	Acetylation	VTYQDIRKISGLKDQ EEHHHHHHHCCCCCC	41.37	7970925
308	Phosphorylation	YQDIRKISGLKDQTV HHHHHHHCCCCCCEE	40.90	24719451
349	Phosphorylation	TQGPIEVYLCPEETE CCCCEEEEECCCCCC	6.98	-
355	Phosphorylation	VYLCPEETETHSPMK EEECCCCCCCCCCCC	44.51	28348404
357	Phosphorylation	LCPEETETHSPMKTN ECCCCCCCCCCCCCC	34.76	28348404
359	Phosphorylation	PEETETHSPMKTNNQ CCCCCCCCCCCCCCC	33.82	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
124	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
124	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:22580460

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E2F3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E2F3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFE3_HUMAN	TFE3	physical	12748276
WNK1_HUMAN	WNK1	physical	12748276
IPKB_HUMAN	PKIB	physical	12748276
CBP_HUMAN	CREBBP	physical	12748276
TEAD3_HUMAN	TEAD3	physical	12748276
MYBB_HUMAN	MYBL2	physical	12748276
MGAP_HUMAN	MGA	physical	12748276
SPIB_HUMAN	SPIB	physical	12748276
RYBP_HUMAN	RYBP	physical	12411495
FHL2_HUMAN	FHL2	physical	12411495
R144A_HUMAN	RNF144A	physical	12411495
SP1_MOUSE	Sp1	physical	8657141
KMT2D_HUMAN	KMT2D	physical	16951254
USF1_HUMAN	USF1	physical	15014447
ATAD2_HUMAN	ATAD2	physical	20855524
HELLS_HUMAN	HELLS	physical	22157815
CCNB1_HUMAN	CCNB1	physical	22157815
RBL1_HUMAN	RBL1	physical	22157815
MCM4_HUMAN	MCM4	physical	22157815
PCNA_HUMAN	PCNA	physical	22157815
FZR1_HUMAN	FZR1	physical	22580460
RB_HUMAN	RB1	physical	17380128
SRA1_HUMAN	SRA1	physical	20398657
TIF1B_HUMAN	TRIM28	physical	23060449
UCHL5_HUMAN	UCHL5	physical	26396186

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.