E2F5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E2F5_HUMAN
• UniProt AC: Q15329
• Protein Name: Transcription factor E2F5
• Gene Name: E2F5
• Organism: Homo sapiens (Human).
• Sequence Length: 346
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis..
• Protein Sequence: MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEIEDLELKERELDQQKLWLQQSIKNVMDDSINNRFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESSSSKPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVQILNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Ubiquitination	GGSSRHEKSLGLLTT CCCCHHHHHHHHHHH	44.87	-
54	Phosphorylation	GSSRHEKSLGLLTTK CCCHHHHHHHHHHHH	25.37	28674419
61	Ubiquitination	SLGLLTTKFVSLLQE HHHHHHHHHHHHHHH	38.23	-
70	Ubiquitination	VSLLQEAKDGVLDLK HHHHHHHHCCCCCHH	55.02	22817900
77	Ubiquitination	KDGVLDLKAAADTLA HCCCCCHHHHHHHHH	35.33	29967540
92	Phosphorylation	VRQKRRIYDITNVLE HHHHHHHHHHHHHHH	10.24	-
124	Ubiquitination	VGAGCNTKEVIDRLR CCCCCCHHHHHHHHH	35.67	29967540
134	Ubiquitination	IDRLRYLKAEIEDLE HHHHHHHHHHHHHHH	34.73	29967540
143	Ubiquitination	EIEDLELKERELDQQ HHHHHHHHHHHHHHH	45.40	29967540
219	Phosphorylation	KYQINLKSHSGPIHV EEEEECCCCCCCEEE	26.50	25219547
221	Phosphorylation	QINLKSHSGPIHVLL EEECCCCCCCEEEEE	54.04	25219547
233	Phosphorylation	VLLINKESSSSKPVV EEEEECCCCCCCCEE	36.81	-
234	Phosphorylation	LLINKESSSSKPVVF EEEECCCCCCCCEEE	39.46	-
235	Phosphorylation	LINKESSSSKPVVFP EEECCCCCCCCEEEE	52.22	-
236	Phosphorylation	INKESSSSKPVVFPV EECCCCCCCCEEEEC	42.82	-
253	Phosphorylation	PDDLTQPSSQSLTPV CCCCCCCCCCCCCCC	31.06	25850435
254	Phosphorylation	DDLTQPSSQSLTPVT CCCCCCCCCCCCCCC	30.39	25850435
256	Phosphorylation	LTQPSSQSLTPVTPQ CCCCCCCCCCCCCCC	35.84	25850435
258	Phosphorylation	QPSSQSLTPVTPQKS CCCCCCCCCCCCCCC	22.44	25850435
261	Phosphorylation	SQSLTPVTPQKSSMA CCCCCCCCCCCCCCC	22.62	30576142
278	Phosphorylation	NLPEQHVSERSQALQ CCCHHHHHHHHHHHH	25.76	28555341
281	Phosphorylation	EQHVSERSQALQQTS HHHHHHHHHHHHHCC	18.76	26074081
287	Phosphorylation	RSQALQQTSATDISS HHHHHHHCCCCCHHH	13.84	26074081
288	Phosphorylation	SQALQQTSATDISSA HHHHHHCCCCCHHHC	25.49	26074081
290	Phosphorylation	ALQQTSATDISSAGS HHHHCCCCCHHHCCC	33.36	26074081
293	Phosphorylation	QTSATDISSAGSISG HCCCCCHHHCCCCCH	19.56	26074081
294	Phosphorylation	TSATDISSAGSISGD CCCCCHHHCCCCCHH	36.66	26074081
297	Phosphorylation	TDISSAGSISGDIID CCHHHCCCCCHHHHH	17.19	26074081
299	Phosphorylation	ISSAGSISGDIIDEL HHHCCCCCHHHHHHH	31.91	26074081
318	Phosphorylation	VFPLLRLSPTPADDY CCCHHHCCCCCCHHC	21.94	26074081
320	Phosphorylation	PLLRLSPTPADDYNF CHHHCCCCCCHHCCC	27.94	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E2F5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E2F5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E2F5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFDP1_HUMAN	TFDP1	physical	7760804
RBL2_HUMAN	RBL2	physical	7760804
KMT2D_HUMAN	KMT2D	physical	16951254
PR38A_HUMAN	PRPF38A	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.