GFRP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GFRP_HUMAN
• UniProt AC: P30047
• Protein Name: GTP cyclohydrolase 1 feedback regulatory protein
• Gene Name: GCHFR
• Organism: Homo sapiens (Human).
• Sequence Length: 84
• Subcellular Localization: Nucleus . Nucleus membrane . Cytoplasm, cytosol .
• Protein Description: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine..
• Protein Sequence: MPYLLISTQIRMEVGPTMVGDEQSDPELMQHLGASKRRALGNNFYEYYVDDPPRIVLDKLERRGFRVLSMTGVGQTLVWCLHKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPYLLISTQI -----CCEEEEEEEE	16.91	23401153
7	Phosphorylation	-MPYLLISTQIRMEV -CCEEEEEEEEEEEC	17.77	23403867
8	Phosphorylation	MPYLLISTQIRMEVG CCEEEEEEEEEEECC	22.48	23401153
17	Phosphorylation	IRMEVGPTMVGDEQS EEEECCCCCCCCCCC	20.68	23403867
35	Phosphorylation	LMQHLGASKRRALGN HHHHHCHHHHHHHCC	25.54	23401153
36	Acetylation	MQHLGASKRRALGNN HHHHCHHHHHHHCCC	45.42	24885225
45	Phosphorylation	RALGNNFYEYYVDDP HHHCCCCEEEECCCC	12.73	27259358
47	Phosphorylation	LGNNFYEYYVDDPPR HCCCCEEEECCCCCC	9.45	-
48	Phosphorylation	GNNFYEYYVDDPPRI CCCCEEEECCCCCCE	5.86	-
48	Ubiquitination	GNNFYEYYVDDPPRI CCCCEEEECCCCCCE	5.86	-
59	Ubiquitination	PPRIVLDKLERRGFR CCCEEEHHHHHCCCE	48.35	-
71	Phosphorylation	GFRVLSMTGVGQTLV CCEEEEEECCCCEEE	25.91	24247654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GFRP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GFRP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GFRP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KKCC2_HUMAN	CAMKK2	physical	28514442
PEBB_HUMAN	CBFB	physical	28514442
PUSL1_HUMAN	PUSL1	physical	28514442
NEBL_HUMAN	NEBL	physical	28514442
IF4G1_HUMAN	EIF4G1	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
DOC11_HUMAN	DOCK11	physical	28514442
HBS1L_HUMAN	HBS1L	physical	28514442
I2BP2_HUMAN	IRF2BP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.