dbPTM

DOC11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DOC11_HUMAN
UniProt AC	Q5JSL3
Protein Name	Dedicator of cytokinesis protein 11 {ECO:0000305}
Gene Name	DOCK11 {ECO:0000312\|HGNC:HGNC:23483}
Organism	Homo sapiens (Human).
Sequence Length	2073
Subcellular Localization
Protein Description	Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42..
Protein Sequence	MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKVVEPLDYENVIAQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINTDSLVQEKKETVETAQDDETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDIKPFEEKCNKRFLVNCHDLTFNILGQIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGSSTQLASDGSPKGSSPESYIHGIAESQLRYIQQGIFSVTNPHPEIFLVARIEKVLQGNITHCAEPYIKNSDPVKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDTQGSLDLDGRFSPLYKQDSSKLSSEDILKLLSEYKKPEKTKLQIIPGQLNITVECVPVDLSNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRIITFEQQLPVSANLPPGYLNLNDAESRRQCNVDIKWVDGAKPLLKIKSHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLDSYLRSFIKYSFRPEKPSAPQAQLIHETLATTMIAILKQSADFLSINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFIFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFTSPANRGSLSTDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDQGNTGENTRQSSTRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTLLTYWNKVSPQELINILILLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSTTTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKTQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRAFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVAEFLHRKKLFPNGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIVPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKYAHIQVTYVKPYFDDKELTERKTEFERNHNISRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQINLKPIDVATDEIKDKTAELQKLCSSTDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNDSQASKYPPKKVSELKDMFRKFIQACSIALELNERLIKEDQVEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMSNTLHVFCAISGTSSDRGYGSPRYAEV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RKFTKRLSKPGTAAE HHHHHHHCCCCCHHH	40.62	19664994
16	Phosphorylation	KRLSKPGTAAELRQS HHHCCCCCHHHHHHH	31.08	23927012
23	Phosphorylation	TAAELRQSVSEAVRG CHHHHHHHHHHHHCC	22.60	28857561
25	Phosphorylation	AELRQSVSEAVRGSV HHHHHHHHHHHCCCH	25.70	28857561
31	Phosphorylation	VSEAVRGSVVLEKAK HHHHHCCCHHEEECE	9.86	28060719
45	Phosphorylation	KVVEPLDYENVIAQR EECCCCCHHHHHHHC	19.65	28796482
53	Malonylation	ENVIAQRKTQIYSDP HHHHHHCCCHHCCCC	32.47	26320211
54	Phosphorylation	NVIAQRKTQIYSDPL HHHHHCCCHHCCCCH	23.53	22985185
57	Phosphorylation	AQRKTQIYSDPLRDL HHCCCHHCCCCHHHH	9.37	23917254
58	Phosphorylation	QRKTQIYSDPLRDLL HCCCHHCCCCHHHHH	34.09	-
83	Phosphorylation	VIGRQRRTVQSTVPE EECCCCCEECCCCCH	25.70	18691976
86	Phosphorylation	RQRRTVQSTVPEDAE CCCCEECCCCCHHHH	27.34	18691976
87	Phosphorylation	QRRTVQSTVPEDAEK CCCEECCCCCHHHHH	24.00	20068231
98	Phosphorylation	DAEKRAQSLFVKECI HHHHHHHHHHHHHHH	23.84	19276368
123	Phosphorylation	NYKYEDFSGDFRMLP EEEECCCCCCEEEEE	50.18	18452278
132	Ubiquitination	DFRMLPCKSLRPEKI CEEEEECCCCCCCCC	51.06	29967540
138	Ubiquitination	CKSLRPEKIPNHVFE CCCCCCCCCCCCEEE	67.17	29967540
156	Phosphorylation	DCEKDEDSSSLCSQK CCCCCCCCCCCHHHC	21.56	23401153
157	Phosphorylation	CEKDEDSSSLCSQKG CCCCCCCCCCHHHCC	39.38	23401153
158	Phosphorylation	EKDEDSSSLCSQKGG CCCCCCCCCHHHCCC	37.03	17525332
161	Phosphorylation	EDSSSLCSQKGGVIK CCCCCCHHHCCCEEE	39.97	17525332
163	Ubiquitination	SSSLCSQKGGVIKQG CCCCHHHCCCEEEEC	41.14	29967540
179	Phosphorylation	LHKANVNSTITVTMK EECCCCCCEEEEEEE	19.53	28555341
248	Phosphorylation	ELKMLDKYSHYLAAE HHHHHHHHHHHHHHC	10.59	19690332
249	Phosphorylation	LKMLDKYSHYLAAET HHHHHHHHHHHHHCC	16.05	19690332
251	Phosphorylation	MLDKYSHYLAAETEQ HHHHHHHHHHHCCHH	7.65	19690332
266	Phosphorylation	EMEEWLITLKKIIQI HHHHHHHHHHHHHHC	30.29	19690332
275	Phosphorylation	KKIIQINTDSLVQEK HHHHHCCCCHHHHHH	28.70	-
277	Phosphorylation	IIQINTDSLVQEKKE HHHCCCCHHHHHHHH	28.53	-
285	Phosphorylation	LVQEKKETVETAQDD HHHHHHHHHHHHCCC	32.30	30108239
288	Phosphorylation	EKKETVETAQDDETS HHHHHHHHHCCCCCC	25.86	30108239
294	Phosphorylation	ETAQDDETSSQGKAE HHHCCCCCCCHHHHH	40.44	30108239
295	Phosphorylation	TAQDDETSSQGKAEN HHCCCCCCCHHHHHH	20.72	30108239
296	Phosphorylation	AQDDETSSQGKAENI HCCCCCCCHHHHHHH	50.82	30108239
304	Sulfoxidation	QGKAENIMASLERSM HHHHHHHHHHHHHHC	2.90	21406390
306	Phosphorylation	KAENIMASLERSMHP HHHHHHHHHHHHCCH	17.24	30576142
322	Phosphorylation	LMKYGRETEQLNKLS HHHHCHHHHHHHCCC	27.89	-
329	Phosphorylation	TEQLNKLSRGDGRQN HHHHHCCCCCCCCCC	35.51	17924679
375	O-linked_Glycosylation	LVNCHDLTFNILGQI EEECCCCCEEECCCC	22.24	27655845
412	Phosphorylation	VKNNCKISADFHVDL CCCCCEECEEEECCC	13.79	24719451
431	Phosphorylation	VREMLWGSSTQLASD HHHHHHCCCCEECCC	20.73	28450419
432	Phosphorylation	REMLWGSSTQLASDG HHHHHCCCCEECCCC	19.08	28450419
433	Phosphorylation	EMLWGSSTQLASDGS HHHHCCCCEECCCCC	29.33	28450419
437	Phosphorylation	GSSTQLASDGSPKGS CCCCEECCCCCCCCC	51.61	30266825
440	Phosphorylation	TQLASDGSPKGSSPE CEECCCCCCCCCCCH	28.56	23401153
444	Phosphorylation	SDGSPKGSSPESYIH CCCCCCCCCCHHHHH	49.17	26074081
445	Phosphorylation	DGSPKGSSPESYIHG CCCCCCCCCHHHHHH	41.16	26074081
448	Phosphorylation	PKGSSPESYIHGIAE CCCCCCHHHHHHHHH	32.54	27080861
449	Phosphorylation	KGSSPESYIHGIAES CCCCCHHHHHHHHHH	8.69	27080861
498	Ubiquitination	HCAEPYIKNSDPVKT EECCCCCCCCCHHHH	44.55	29967540
500	Phosphorylation	AEPYIKNSDPVKTAQ CCCCCCCCCHHHHHH	37.99	-
505	Phosphorylation	KNSDPVKTAQKVHRT CCCCHHHHHHHHHHH	34.26	-
527	Ubiquitination	LGQYRMPFAWAARPI HCCCCCCCCEEECCC	6.92	22817900
532	Ubiquitination	MPFAWAARPIFKDTQ CCCCEEECCCCCCCC	19.66	21890473
553	Ubiquitination	GRFSPLYKQDSSKLS CCCCCCCCCCCCCCC	56.14	29967540
560	Phosphorylation	KQDSSKLSSEDILKL CCCCCCCCHHHHHHH	35.10	-
571	Phosphorylation	ILKLLSEYKKPEKTK HHHHHHHCCCCCCCC	22.42	-
631	Acetylation	EFVPEMTKYCYPFTI HHHHHHHHCCCEEEE	31.82	11925349
656	Ubiquitination	QLKYDSQKTFAKARN EEECCCHHHHHHHCC	49.95	29967540
731	Phosphorylation	QKHHLLFTFYHVSCE HCCEEEEEEEEEEEE	24.21	-
914	Phosphorylation	GLDSYLRSFIKYSFR CHHHHHHHHHHHHCC	28.82	24719451
1010	Phosphorylation	LAIIPHVTIRYAEIP HHHHCCCEEEECCCC	9.19	-
1026	Phosphorylation	ESRNVNYSLASFLKR CCCCCCHHHHHHHHH	16.56	22210691
1029	Phosphorylation	NVNYSLASFLKRCLT CCCHHHHHHHHHHHH	36.08	18691976
1052	Phosphorylation	NLINDYISGFSPKDP HHHHHHHCCCCCCCH	27.79	22210691
1055	Phosphorylation	NDYISGFSPKDPKVL HHHHCCCCCCCHHHH	34.27	22210691
1123	Phosphorylation	VGLLLRETSIALQDN HHHHHHHHCHHCCCC	20.99	28111955
1124	Phosphorylation	GLLLRETSIALQDNY HHHHHHHCHHCCCCC	10.91	28111955
1124	Ubiquitination	GLLLRETSIALQDNY HHHHHHHCHHCCCCC	10.91	22817900
1129	Ubiquitination	ETSIALQDNYEIRYT HHCHHCCCCCEEHHH	61.60	21890473
1131	Ubiquitination	SIALQDNYEIRYTAI CHHCCCCCEEHHHHH	22.48	22817900
1135	Phosphorylation	QDNYEIRYTAISVIK CCCCEEHHHHHHHHH	13.24	22210691
1136	Phosphorylation	DNYEIRYTAISVIKN CCCEEHHHHHHHHHH	13.99	22210691
1136	Ubiquitination	DNYEIRYTAISVIKN CCCEEHHHHHHHHHH	13.99	21890473
1142	Ubiquitination	YTAISVIKNLLIKHA HHHHHHHHHHHHHHH	39.11	22817900
1147	Ubiquitination	VIKNLLIKHAFDTRY HHHHHHHHHHHHCCC	28.93	21890473
1155	Ubiquitination	HAFDTRYQHKNQQAK HHHHCCCCCCCHHHH	37.48	22817900
1160	Ubiquitination	RYQHKNQQAKIAQLY CCCCCCHHHHHHHHH	54.75	21890473
1188	Phosphorylation	LAGRDTLYSCAAMPN HCCCCCHHHHHCCCC	12.09	27259358
1198	Phosphorylation	AAMPNSASRDEFPCG HCCCCCCCCCCCCCC	39.83	32142685
1207	Phosphorylation	DEFPCGFTSPANRGS CCCCCCCCCCCCCCC	21.05	25262027
1208	Phosphorylation	EFPCGFTSPANRGSL CCCCCCCCCCCCCCC	21.54	21712546
1214	Phosphorylation	TSPANRGSLSTDKDT CCCCCCCCCCCCCCC	18.86	28555341
1216	Phosphorylation	PANRGSLSTDKDTAY CCCCCCCCCCCCCCC	35.94	28555341
1217	Phosphorylation	ANRGSLSTDKDTAYG CCCCCCCCCCCCCCC	52.97	29214152
1221	Phosphorylation	SLSTDKDTAYGSFQN CCCCCCCCCCCCCCC	27.76	25884760
1223	Phosphorylation	STDKDTAYGSFQNGH CCCCCCCCCCCCCCC	18.52	25884760
1225	Phosphorylation	DKDTAYGSFQNGHGI CCCCCCCCCCCCCCC	15.81	19651622
1237	Phosphorylation	HGIKREDSRGSLIPE CCCCCCCCCCCCCCC	33.51	23401153
1240	Phosphorylation	KREDSRGSLIPEGAT CCCCCCCCCCCCCCC	23.24	22167270
1247	Phosphorylation	SLIPEGATGFPDQGN CCCCCCCCCCCCCCC	50.65	23927012
1255	Phosphorylation	GFPDQGNTGENTRQS CCCCCCCCCCCCCCC	53.34	23186163
1259	Phosphorylation	QGNTGENTRQSSTRS CCCCCCCCCCCCCCC	26.28	23186163
1266	Phosphorylation	TRQSSTRSSVSQYNR CCCCCCCCCHHHHHC	34.87	29978859
1267	Phosphorylation	RQSSTRSSVSQYNRL CCCCCCCCHHHHHCC	23.61	30576142
1269	Phosphorylation	SSTRSSVSQYNRLDQ CCCCCCHHHHHCCCH	28.97	29978859
1271	Phosphorylation	TRSSVSQYNRLDQYE CCCCHHHHHCCCHHH	8.51	29978859
1277	Phosphorylation	QYNRLDQYEIRSLLM HHHCCCHHHHHHHHH	17.00	29978859
1281	Phosphorylation	LDQYEIRSLLMCYLY CCHHHHHHHHHHHHH	31.36	29978859
1286	Phosphorylation	IRSLLMCYLYIVKMI HHHHHHHHHHHHHHC	6.64	29978859
1288	Phosphorylation	SLLMCYLYIVKMISE HHHHHHHHHHHHCCC	4.17	29978859
1350	Phosphorylation	HFGIDRKSQTMPALR HHCCCCHHCCHHHHH	31.60	28555341
1352	Phosphorylation	GIDRKSQTMPALRNR CCCCHHCCHHHHHCC	32.01	23911959
1378	Phosphorylation	SSLESSFTLNHSSTT HCCHHCEECCCCCCC	28.70	-
1506	Phosphorylation	NEASALLYLLMRNNF HHHHHHHHHHHHCCC	9.91	20049867
1577	Phosphorylation	PAEVKDLTKRIRTVL CHHHHHHHHHHHHHH	28.54	22468782
1582	Phosphorylation	DLTKRIRTVLMATAQ HHHHHHHHHHHHHHH	18.67	21406692
1587	Phosphorylation	IRTVLMATAQMKEHE HHHHHHHHHHHHHHC	11.94	21406692
1605	Phosphorylation	EMLIDLQYSLAKSYA HHHHHHHHHHHHHHC	16.98	-
1611	Phosphorylation	QYSLAKSYASTPELR HHHHHHHHCCCHHHH	12.13	-
1614	Phosphorylation	LAKSYASTPELRKTW HHHHHCCCHHHHHHH	16.77	24719451
1620	Phosphorylation	STPELRKTWLDSMAK CCHHHHHHHHHHHCC	25.48	20068231
1624	Phosphorylation	LRKTWLDSMAKIHVK HHHHHHHHHCCEEEC	20.61	20068231
1636	Phosphorylation	HVKNGDFSEAAMCYV EECCCCHHHHHHHHH	30.94	20068231
1642	Phosphorylation	FSEAAMCYVHVAALV HHHHHHHHHHHHHHH	4.78	20068231
1712	Phosphorylation	GLWKAERYEIISEIS HHHHHHHHHHHHHHH	11.73	23403867
1790	Phosphorylation	IYKEPKLTGLSEISL EEECCCCCCCCHHHH	42.05	-
1809	Phosphorylation	LYGEKFGTENVKIIQ HHHHHHCCCCEEEEE	27.76	-
1869	Phosphorylation	RFVFEAPYTLSGKKQ EEEEECCCCCCCCCC	27.62	24719451
1870	Phosphorylation	FVFEAPYTLSGKKQG EEEECCCCCCCCCCC	17.25	24719451
1874	Acetylation	APYTLSGKKQGCIEE CCCCCCCCCCCCHHH	38.25	25953088
2017	Ubiquitination	VEYHEGLKSNFRDMV HHHHHHHHHHHHHHH	54.96	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DOC11_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DOC11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DOC11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DOC11_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DOC11_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-248 AND SER-440, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158 AND SER-161, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, AND MASSSPECTROMETRY.	17924679 [Abstract]