MNDA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MNDA_HUMAN
• UniProt AC: P41218
• Protein Name: Myeloid cell nuclear differentiation antigen
• Gene Name: MNDA
• Organism: Homo sapiens (Human).
• Sequence Length: 407
• Subcellular Localization: Nucleus. Cytoplasm. Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
• Protein Description: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1..
• Protein Sequence: MVNEYKKILLLKGFELMDDYHFTSIKSLLAYDLGLTTKMQEEYNRIKITDLMEKKFQGVACLDKLIELAKDMPSLKNLVNNLRKEKSKVAKKIKTQEKAPVKKINQEEVGLAAPAPTARNKLTSEARGRIPVAQKRKTPNKEKTEAKRNKVSQEQSKPPGPSGASTSAAVDHPPLPQTSSSTPSNTSFTPNQETQAQRQVDARRNVPQNDPVTVVVLKATAPFKYESPENGKSTMFHATVASKTQYFHVKVFDINLKEKFVRKKVITISDYSECKGVMEIKEASSVSDFNQNFEVPNRIIEIANKTPKISQLYKQASGTMVYGLFMLQKKSVHKKNTIYEIQDNTGSMDVVGSGKWHNIKCEKGDKLRLFCLQLRTVDRKLKLVCGSHSFIKVIKAKKNKEGPMNVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	SIKSLLAYDLGLTTK CHHHHHHHHCCCCHH	16.21	29083192
36	Phosphorylation	LAYDLGLTTKMQEEY HHHHCCCCHHHHHHH	23.67	29083192
37	Phosphorylation	AYDLGLTTKMQEEYN HHHCCCCHHHHHHHH	29.57	29083192
43	Phosphorylation	TTKMQEEYNRIKITD CHHHHHHHHCCCHHH	14.69	29083192
102	Acetylation	TQEKAPVKKINQEEV CCCCCCCCCCCHHHH	47.04	18530433
103	Acetylation	QEKAPVKKINQEEVG CCCCCCCCCCHHHHH	47.31	7684827
135	Acetylation	GRIPVAQKRKTPNKE CCCCCCCCCCCCCHH	46.23	7696521
144	Phosphorylation	KTPNKEKTEAKRNKV CCCCHHHHHHHHHCC	42.12	-
227	Phosphorylation	TAPFKYESPENGKST ECCCEECCCCCCCCC	34.13	28450419
250	Acetylation	KTQYFHVKVFDINLK CCCEEEEEEEECCCC	28.72	25038526
310	Phosphorylation	ANKTPKISQLYKQAS HHCCCCHHHHHHHHH	21.91	29978859
313	Phosphorylation	TPKISQLYKQASGTM CCCHHHHHHHHHCCE	8.07	29978859
317	Phosphorylation	SQLYKQASGTMVYGL HHHHHHHHCCEEEEE	32.10	29978859
319	Phosphorylation	LYKQASGTMVYGLFM HHHHHHCCEEEEEEH	10.85	29978859
322	Phosphorylation	QASGTMVYGLFMLQK HHHCCEEEEEEHHHC	9.40	29978859
331	Phosphorylation	LFMLQKKSVHKKNTI EEHHHCCCCCCCCCE	36.17	-
337	Phosphorylation	KSVHKKNTIYEIQDN CCCCCCCCEEEEECC	33.54	-
339	Phosphorylation	VHKKNTIYEIQDNTG CCCCCCEEEEECCCC	12.63	-
387	Phosphorylation	KLKLVCGSHSFIKVI HHHHHHCCCCHHHHH	15.72	28450419
389	Phosphorylation	KLVCGSHSFIKVIKA HHHHCCCCHHHHHHH	30.29	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MNDA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MNDA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MNDA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NSD3_HUMAN	WHSC1L1	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
ANM7_HUMAN	PRMT7	physical	23455924

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.