dbPTM

CRP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CRP_HUMAN
UniProt AC	P02741
Protein Name	C-reactive protein
Gene Name	CRP
Organism	Homo sapiens (Human).
Sequence Length	224
Subcellular Localization	Secreted.
Protein Description	Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells..
Protein Sequence	MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Methylation	-----MEKLLCFLVL -----CHHHHHHHHH	45.52	-
19	Pyrrolidone_carboxylic_acid	SLSHAFGQTDMSRKA HHHHHHCCCCCCCCE	28.07	-
19	Pyrrolidone_carboxylic_acid	SLSHAFGQTDMSRKA HHHHHHCCCCCCCCE	28.07	762075
19	Pyrrolidone_carboxylic_acid	SLSHAFGQTDMSRKA HHHHHHCCCCCCCCE	28.07	762075

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CRP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CRP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CRP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CFAH_HUMAN	CFH	physical	10490997
C1QA_HUMAN	C1QA	physical	10490997
RU17_HUMAN	SNRNP70	physical	2477447
SAMP_HUMAN	APCS	physical	8144569
H11_HUMAN	HIST1H1A	physical	1989977
H2A2C_HUMAN	HIST2H2AC	physical	1989977
LAMC3_HUMAN	LAMC3	physical	21988832
DHE3_HUMAN	GLUD1	physical	21988832
MK01_HUMAN	MAPK1	physical	21988832
DGC14_HUMAN	DGCR14	physical	21988832
RL13A_HUMAN	RPL13A	physical	21988832
GMPPA_HUMAN	GMPPA	physical	25416956
CHST3_HUMAN	CHST3	physical	28514442
LAMA5_HUMAN	LAMA5	physical	28514442
PRS23_HUMAN	PRSS23	physical	28514442
TMEM2_HUMAN	TMEM2	physical	28514442
AGRIN_HUMAN	AGRN	physical	28514442
SPTB1_HUMAN	SPTB	physical	28514442
GDF11_HUMAN	GDF11	physical	28514442
C1GLT_HUMAN	C1GALT1	physical	28514442
UBR3_HUMAN	UBR3	physical	28514442
QSOX1_HUMAN	QSOX1	physical	28514442
COIA1_HUMAN	COL18A1	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
LAMA1_HUMAN	LAMA1	physical	28514442
CAH11_HUMAN	CA11	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
NXPE3_HUMAN	NXPE3	physical	28514442
CNTP3_HUMAN	CNTNAP3	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
PTPRS_HUMAN	PTPRS	physical	28514442
SIA4C_HUMAN	ST3GAL4	physical	28514442
LAMB1_HUMAN	LAMB1	physical	28514442
B4GT7_HUMAN	B4GALT7	physical	28514442
EXT1_HUMAN	EXT1	physical	28514442
CHSTC_HUMAN	CHST12	physical	28514442
B4GT5_HUMAN	B4GALT5	physical	28514442
STRBP_HUMAN	STRBP	physical	28514442
NDST2_HUMAN	NDST2	physical	28514442
H6ST1_HUMAN	HS6ST1	physical	28514442
B4GT3_HUMAN	B4GALT3	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
STC2_HUMAN	STC2	physical	28514442
CO4A2_HUMAN	COL4A2	physical	28514442
LAMB2_HUMAN	LAMB2	physical	28514442
IMPA3_HUMAN	IMPAD1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CRP_HUMAN

Related Literatures of Post-Translational Modification

Pyrrolidone carboxylic acid
Reference	PubMed
"Primary structure of human C-reactive protein."; Oliveira E.B., Gotschlich E.C., Liu T.-Y.; J. Biol. Chem. 254:489-502(1979). Cited for: PROTEIN SEQUENCE OF 19-224.	762075 [Abstract]