GALT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALT3_HUMAN
• UniProt AC: Q14435
• Protein Name: Polypeptide N-acetylgalactosaminyltransferase 3
• Gene Name: GALNT3
• Organism: Homo sapiens (Human).
• Sequence Length: 633
• Subcellular Localization: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Resides preferentially in the trans and medial parts of the Golgi stack.
• Protein Description: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis..
• Protein Sequence: MAHLKRLVKLHIKRHYHKKFWKLGAVIFFFIIVLVLMQREVSVQYSKEESRMERNMKNKNKMLDLMLEAVNNIKDAMPKMQIGAPVRQNIDAGERPCLQGYYTAAELKPVLDRPPQDSNAPGASGKAFKTTNLSVEEQKEKERGEAKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDEYLHDKLDEYVKQFSIVKIVRQRERKGLITARLLGATVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRRKDETYPIKTPTFAGGLFSISKEYFEYIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHSFPKGTQVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKAFGDLSKRFEIKHRLQCKNFTWYLNNIYPEVYVPDLNPVISGYIKSVGQPLCLDVGENNQGGKPLIMYTCHGLGGNQYFEYSAQHEIRHNIQKELCLHAAQGLVQLKACTYKGHKTVVTGEQIWEIQKDQLLYNPFLKMCLSANGEHPSLVSCNPSDPLQKWILSQND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	VLMQREVSVQYSKEE HHHHHHHHHCCCHHH	9.96	22210691
130	O-linked_Glycosylation	ASGKAFKTTNLSVEE CCCCCEECCCCCHHH	17.92	55824007
130	Phosphorylation	ASGKAFKTTNLSVEE CCCCCEECCCCCHHH	17.92	28102081
131	O-linked_Glycosylation	SGKAFKTTNLSVEEQ CCCCEECCCCCHHHH	34.45	55824011
131	Phosphorylation	SGKAFKTTNLSVEEQ CCCCEECCCCCHHHH	34.45	28102081
132	N-linked_Glycosylation	GKAFKTTNLSVEEQK CCCEECCCCCHHHHH	35.23	UniProtKB CARBOHYD
134	Phosphorylation	AFKTTNLSVEEQKEK CEECCCCCHHHHHHH	29.56	26657352
297	N-linked_Glycosylation	LLARIAENYTAVVSP HHHHHHHHCEEEECC	30.36	UniProtKB CARBOHYD
395	Phosphorylation	GGENIEMSFRVWQCG CCCCEEEEEEEEEEC	9.34	24719451
421	Phosphorylation	GHVFRSKSPHSFPKG EEEECCCCCCCCCCC	29.14	28674419
447	Phosphorylation	AEVWMDEYKEIFYRR HHHHHHHHHHHHHHC	15.06	-
460	Acetylation	RRNTDAAKIVKQKAF HCCCCHHHHHHHHHH	50.15	11789869
472	Acetylation	KAFGDLSKRFEIKHR HHHCCHHHHHHEEHH	69.29	11789879
484	N-linked_Glycosylation	KHRLQCKNFTWYLNN EHHHCCCCEEEHHCC	47.40	UniProtKB CARBOHYD
598	Phosphorylation	IQKDQLLYNPFLKMC EECCHHHCCHHHHHH	29.40	-
626	Acetylation	NPSDPLQKWILSQND CCCCHHHHHHHCCCC	43.83	19815523

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBP2_HUMAN	APPBP2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.