| UniProt ID | EGFL6_HUMAN | |
|---|---|---|
| UniProt AC | Q8IUX8 | |
| Protein Name | Epidermal growth factor-like protein 6 | |
| Gene Name | EGFL6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 553 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane. | |
| Protein Description | May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity).. | |
| Protein Sequence | MPLPWSLALPLLLSWVAGGFGNAASARHHGLLASARQPGVCHYGTKLACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTIKDRIKKLLAHKNSMKKKAKIKNVTPEPTRTPTPKVNLQPFNYEEIVSRGGNSHGGKKGNEEKMKEGLEDEKREEKALKNDIEERSLRGDVFFPKVNEAGEFGLILVQRKALTSKLEHKDLNISVDCSFNHGICDWKQDREDDFDWNPADRDNAIGFYMAVPALAGHKKDIGRLKLLLPDLQPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEKTTSEDEKWKTGKIQLYQGTDATKSIIFEAERGKGKTGEIAVDGVLLVSGLCPDSLLSVDD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 86 | Phosphorylation | KCRCFPGYTGKTCSQ CCEECCCCCCCCCCC | 16.74 | - | |
| 289 | Phosphorylation | KLLAHKNSMKKKAKI HHHHCCHHHHCCCCC | 36.46 | 26657352 | |
| 332 | Acetylation | GGNSHGGKKGNEEKM CCCCCCCCCCCHHHH | 63.20 | 20167786 | |
| 333 | Acetylation | GNSHGGKKGNEEKMK CCCCCCCCCCHHHHH | 70.96 | 20167786 | |
| 338 | Acetylation | GKKGNEEKMKEGLED CCCCCHHHHHHHHHH | 49.44 | 20167786 | |
| 397 | N-linked_Glycosylation | KLEHKDLNISVDCSF CCCCCCCCEEEEEEC | 34.32 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EGFL6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EGFL6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EGFL6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SH3G2_HUMAN | SH3GL2 | physical | 16169070 | |
| SH3G3_HUMAN | SH3GL3 | physical | 16169070 | |
| CC85C_HUMAN | CCDC85C | physical | 28514442 | |
| ZZEF1_HUMAN | ZZEF1 | physical | 28514442 | |
| ALG13_HUMAN | ALG13 | physical | 28514442 | |
| SORL_HUMAN | SORL1 | physical | 28514442 | |
| HECD3_HUMAN | HECTD3 | physical | 28514442 | |
| HDGF_HUMAN | HDGF | physical | 28514442 | |
| LRP2_HUMAN | LRP2 | physical | 28514442 | |
| FA8A1_HUMAN | FAM8A1 | physical | 28514442 | |
| SYVN1_HUMAN | SYVN1 | physical | 28514442 | |
| IDE_HUMAN | IDE | physical | 28514442 | |
| LRP1B_HUMAN | LRP1B | physical | 28514442 | |
| LDLR_HUMAN | LDLR | physical | 28514442 | |
| GRP78_HUMAN | HSPA5 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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