FBX32_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX32_HUMAN
• UniProt AC: Q969P5
• Protein Name: F-box only protein 32
• Gene Name: FBXO32
• Organism: Homo sapiens (Human).
• Sequence Length: 355
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1..
• Protein Sequence: MPFLGQDWRSPGQNWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRPAFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRKEQYGDTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Ubiquitination	SPGQNWVKTADGWKR CCCCCCEECCHHHHH	29.61	21890473
29	Ubiquitination	WKRFLDEKSGSFVSD HHHHHHCCCCCHHHH	60.84	-
30	Phosphorylation	KRFLDEKSGSFVSDL HHHHHCCCCCHHHHH	37.31	-
32	Phosphorylation	FLDEKSGSFVSDLSS HHHCCCCCHHHHHHH	29.57	-
48	Ubiquitination	CNKEVYNKENLFNSL CCHHHCCCCHHHHHC	30.23	21906983
71	Phosphorylation	RKKDMLNSKTKTQYF HHHHHHCCCCCCCEE	37.43	29083192
73	Phosphorylation	KDMLNSKTKTQYFHQ HHHHCCCCCCCEEEC	38.86	29083192
75	Phosphorylation	MLNSKTKTQYFHQEK HHCCCCCCCEEECCC	33.46	29083192
77	Phosphorylation	NSKTKTQYFHQEKWI CCCCCCCEEECCCEE	14.30	29083192
82	Ubiquitination	TQYFHQEKWIYVHKG CCEEECCCEEEEECC	32.11	-
143	Ubiquitination	SLSGIAQKNFMNILE CCHHHHHHHHHHHHH	43.03	-
224	Phosphorylation	RPAFKGLTFTDLPLC CCCCCCCCCCCHHHH	32.91	27251275
226	Phosphorylation	AFKGLTFTDLPLCLQ CCCCCCCCCHHHHHH	31.24	27251275
248	Phosphorylation	SDGRDLVSLGQAAPD CCCCCHHHHCCCCCC	33.80	28348404
260	Phosphorylation	APDLHVLSEDRLLWK CCCCEECCHHHHHHH	36.04	25850435
268	Ubiquitination	EDRLLWKKLCQYHFS HHHHHHHHHHHHHCC	42.80	-
333	Phosphorylation	KGTDHPCTANNPESC CCCCCCCCCCCCCCC	36.55	-
345	Phosphorylation	ESCSVSLSPQDFINL CCCEEECCHHHHHHH	17.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX32_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX32_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX32_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1_HUMAN	SKP1	physical	11717410
EIF3F_HUMAN	EIF3F	physical	19073596
CDN1A_HUMAN	CDKN1A	physical	21546904
MYPC3_HUMAN	MYBPC3	physical	19850579
DUS1_HUMAN	DUSP1	physical	19117950
SPB5_HUMAN	SERPINB5	physical	21725612
UB2R1_HUMAN	CDC34	physical	19073596
MUTYH_MOUSE	Mutyh	physical	21964591
UB2D3_HUMAN	UBE2D3	physical	21964591
MYOD1_HUMAN	MYOD1	physical	15531760
EIF3F_HUMAN	EIF3F	physical	18354498
KLF4_HUMAN	KLF4	physical	28068319
CUL1_HUMAN	CUL1	physical	26753747
RBX1_HUMAN	RBX1	physical	26753747
SKP1_HUMAN	SKP1	physical	26753747
SH3G2_HUMAN	SH3GL2	physical	27720640
SH3G1_HUMAN	SH3GL1	physical	27720640

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.