DUS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS1_HUMAN
• UniProt AC: P28562
• Protein Name: Dual specificity protein phosphatase 1 {ECO:0000305}
• Gene Name: DUSP1 {ECO:0000312|HGNC:HGNC:3064}
• Organism: Homo sapiens (Human).
• Sequence Length: 367
• Subcellular Localization: Nucleus .
• Protein Description: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle..
• Protein Sequence: MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Acetylation	TIVRRRAKGAMGLEH HHHHHHCCCCCCCCE	45.45	18504304
57	Ubiquitination	TIVRRRAKGAMGLEH HHHHHHCCCCCCCCE	45.45	-
97	Acetylation	SAALDGAKRDGTLAL HHHHCCCCCCCHHHH	57.46	30590427
97	Ubiquitination	SAALDGAKRDGTLAL HHHHCCCCCCCHHHH	57.46	-
122	Ubiquitination	AAQVFFLKGGYEAFS HCEEEEECCHHHHHH	45.17	-
140	Phosphorylation	PELCSKQSTPMGLSL HHHHCCCCCCCEEEC	37.91	-
141	Phosphorylation	ELCSKQSTPMGLSLP HHHCCCCCCCEEECC	18.14	-
146	Phosphorylation	QSTPMGLSLPLSTSV CCCCCEEECCCCCCC	23.39	-
221	Ubiquitination	FEGHYQYKSIPVEDN CCCCCEEEECCCCCC	26.78	-
230	Ubiquitination	IPVEDNHKADISSWF CCCCCCCCCCHHHHH	54.75	-
280	Ubiquitination	LMRTNRVKLDEAFEF HHHCCCCCHHHHHHH	47.16	21906983
289	Ubiquitination	DEAFEFVKQRRSIIS HHHHHHHHHHCCCCC	43.33	21906983
296	Phosphorylation	KQRRSIISPNFSFMG HHHCCCCCCCCCHHH	16.48	16286470
323	Phosphorylation	HCSAEAGSPAMAVLD CCCCCCCCCCEEEEE	19.28	16286470
334	Phosphorylation	AVLDRGTSTTTVFNF EEEECCCCEEEEEEC	26.95	-
359	Phosphorylation	SALSYLQSPITTSPS CHHHHHCCCCCCCCC	18.70	18477563
364	Phosphorylation	LQSPITTSPSC---- HCCCCCCCCCC----	13.23	10617468

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
296	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
323	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
334	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
359	S	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
359	S	Phosphorylation	Kinase	ERK1	P27361	PSP
364	S	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
364	S	Phosphorylation	Kinase	MK03	P27361	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO32	Q969P5	PMID:19117950
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:16286470

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
359	S	Phosphorylation	Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.	-
364	S	Phosphorylation	Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK09_HUMAN	MAPK9	physical	11359773
MK10_HUMAN	MAPK10	physical	11359773
MK03_HUMAN	MAPK3	physical	11278799
MK01_HUMAN	MAPK1	physical	11278799
MK08_HUMAN	MAPK8	physical	11278799
MK14_HUMAN	MAPK14	physical	11278799
MK01_HUMAN	MAPK1	physical	18519678
SKP2_HUMAN	SKP2	physical	18519678
CKS1_HUMAN	CKS1B	physical	18519678
IKKA_HUMAN	CHUK	physical	10022904
IKKB_HUMAN	IKBKB	physical	10022904
KPCI_HUMAN	PRKCI	physical	10022904
HSP74_HUMAN	HSPA4	physical	15677475
RPA12_HUMAN	ZNRD1	physical	21988832
MK14_HUMAN	MAPK14	physical	27880917
DUS1_HUMAN	DUSP1	physical	27432908
MK14_HUMAN	MAPK14	physical	27432908
SNX17_HUMAN	SNX17	physical	27432908
ABHEB_HUMAN	ABHD14B	physical	27432908
COPZ1_HUMAN	COPZ1	physical	27432908
ICMT_HUMAN	ICMT	physical	27432908
DUS3_HUMAN	DUSP3	physical	27432908
COX41_HUMAN	COX4I1	physical	27432908
SPEE_HUMAN	SRM	physical	27432908
PARK7_HUMAN	PARK7	physical	27432908
AP3S1_HUMAN	AP3S1	physical	27432908
APT_HUMAN	APRT	physical	27432908
NDUAD_HUMAN	NDUFA13	physical	27432908
MK01_HUMAN	MAPK1	physical	27432908
PPAC_HUMAN	ACP1	physical	27432908
BIEA_HUMAN	BLVRA	physical	27432908
ECHD1_HUMAN	ECHDC1	physical	27432908
HDDC2_HUMAN	HDDC2	physical	27432908
SGMR2_HUMAN	TMEM97	physical	27432908

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.