dbPTM

MUTYH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MUTYH_MOUSE
UniProt AC	Q99P21
Protein Name	Adenine DNA glycosylase
Gene Name	Mutyh
Organism	Mus musculus (Mouse).
Sequence Length	515
Subcellular Localization	Nucleus . Mitochondrion .
Protein Description	Involved in oxidative DNA damage repair. Initiates repair of AoxoG to CG by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities..
Protein Sequence	MKKLQASVRSHKKQPANHKRRRTRALSSSQAKPSSLDGLAKQKREELLQASVSPYHLFSDVADVTAFRSNLLSWYDQEKRDLPWRNLAKEEANSDRRAYAVWVSEVMLQQTQVATVIDYYTRWMQKWPKLQDLASASLEEVNQLWSGLGYYSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFDQVTGVVDGNVLRVLCRVRAIGADPTSTLVSHHLWNLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSHCPVQSLCRAYQRVQRGQLSALPGRPDIEECALNTRQCQLCLTSSSPWDPSMGVANFPRKASRRPPREEYSATCVVEQPGAIGGPLVLLVQRPDSGLLAGLWEFPSVTLEPSEQHQHKALLQELQRWCGPLPAIRLQHLGEVIHIFSHIKLTYQVYSLALDQAPASTAPPGARWLTWEEFCNAAVSTAMKKVFRMYEDHRQGTRKGSKRSQVCPPSSRKKPSLGQQVLDTFFQRHIPTDKPNSTTQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	RRRTRALSSSQAKPS HHHHHHHCCCCCCCC	27.27	26745281
28	Phosphorylation	RRTRALSSSQAKPSS HHHHHHCCCCCCCCC	27.59	27566939
29	Phosphorylation	RTRALSSSQAKPSSL HHHHHCCCCCCCCCC	30.68	26745281
331	Phosphorylation	ANFPRKASRRPPREE CCCCCCCCCCCCCHH	31.68	27717184
491	Phosphorylation	PSSRKKPSLGQQVLD CHHCCCCCHHHHHHH	54.75	27600695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MUTYH_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MUTYH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MUTYH_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
FBX32_MOUSE	Fbxo32	physical	21964591

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MUTYH_MOUSE

Related Literatures of Post-Translational Modification