TM108_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM108_HUMAN
• UniProt AC: Q6UXF1
• Protein Name: Transmembrane protein 108 {ECO:0000312|HGNC:HGNC:28451}
• Gene Name: TMEM108 {ECO:0000312|HGNC:HGNC:28451}
• Organism: Homo sapiens (Human).
• Sequence Length: 575
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Endosome membrane . Cell projection, axon . Cell projection, dendrite . Early endosome .
• Protein Description: Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes..
• Protein Sequence: MKRSLQALYCQLLSFLLILALTEALAFAIQEPSPRESLQVLPSGTPPGTMVTAPHSSTRHTSVVMLTPNPDGPPSQAAAPMATPTPRAEGHPPTHTISTIAATVTAPHSESSLSTGPAPAAMATTSSKPEGRPRGQAAPTILLTKPPGATSRPTTAPPRTTTRRPPRPPGSSRKGAGNSSRPVPPAPGGHSRSKEGQRGRNPSSTPLGQKRPLGKIFQIYKGNFTGSVEPEPSTLTPRTPLWGYSSSPQPQTVAATTVPSNTSWAPTTTSLGPAKDKPGLRRAAQGGGSTFTSQGGTPDATAASGAPVSPQAAPVPSQRPHHGDPQDGPSHSDSWLTVTPGTSRPLSTSSGVFTAATGPTPAAFDTSVSAPSQGIPQGASTTPQAPTHPSRVSESTISGAKEETVATLTMTDRVPSPLSTVVSTATGNFLNRLVPAGTWKPGTAGNISHVAEGDKPQHRATICLSKMDIAWVILAISVPISSCSVLLTVCCMKRKKKTANPENNLSYWNNTITMDYFNRHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
150	Phosphorylation	LTKPPGATSRPTTAP EECCCCCCCCCCCCC	31.05	22210691
151	Phosphorylation	TKPPGATSRPTTAPP ECCCCCCCCCCCCCC	35.41	22210691
160	Phosphorylation	PTTAPPRTTTRRPPR CCCCCCCCCCCCCCC	37.99	24043423
161	Phosphorylation	TTAPPRTTTRRPPRP CCCCCCCCCCCCCCC	21.42	24043423
162	Phosphorylation	TAPPRTTTRRPPRPP CCCCCCCCCCCCCCC	24.86	24043423
171	Phosphorylation	RPPRPPGSSRKGAGN CCCCCCCCCCCCCCC	32.51	22210691
172	Phosphorylation	PPRPPGSSRKGAGNS CCCCCCCCCCCCCCC	43.88	22210691
178	N-linked_Glycosylation	SSRKGAGNSSRPVPP CCCCCCCCCCCCCCC	35.96	UniProtKB CARBOHYD
191	Phosphorylation	PPAPGGHSRSKEGQR CCCCCCCCCCCCCCC	41.34	27732954
223	N-linked_Glycosylation	IFQIYKGNFTGSVEP EEEEECCCCCCCCCC	27.44	UniProtKB CARBOHYD
236	Phosphorylation	EPEPSTLTPRTPLWG CCCCCCCCCCCCCCC	15.71	24719451
239	Phosphorylation	PSTLTPRTPLWGYSS CCCCCCCCCCCCCCC	24.76	22210691
261	N-linked_Glycosylation	AATTVPSNTSWAPTT EEEECCCCCCCCCCC	31.87	UniProtKB CARBOHYD
426	Phosphorylation	STVVSTATGNFLNRL HHEEECCCCCHHHHC	32.52	-
446	N-linked_Glycosylation	WKPGTAGNISHVAEG CCCCCCCCCEECCCC	30.08	UniProtKB CARBOHYD
482	Phosphorylation	AISVPISSCSVLLTV HHCCCHHHHHHHHHH	15.90	22210691
507	Phosphorylation	NPENNLSYWNNTITM CCCCCCCHHCCEECH	18.47	25884760
516	Phosphorylation	NNTITMDYFNRHAVE CCEECHHHHHHHHCC	7.60	25884760
530	Phosphorylation	ELPREIQSLETSEDQ CCCHHHHHCCCCHHH	33.56	27732954
533	Phosphorylation	REIQSLETSEDQLSE HHHHHCCCCHHHHCC	42.59	24719451
534	Phosphorylation	EIQSLETSEDQLSEP HHHHCCCCHHHHCCC	29.78	29978859
539	Phosphorylation	ETSEDQLSEPRSPAN CCCHHHHCCCCCCCC	39.66	29978859
543	Phosphorylation	DQLSEPRSPANGDYR HHHCCCCCCCCCCCC	38.79	25921289
549	Phosphorylation	RSPANGDYRDTGMVL CCCCCCCCCCCCEEE	16.28	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM108_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM108_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM108_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RRN3_HUMAN	RRN3	physical	28514442
TCAF2_HUMAN	FAM115C	physical	28514442
PO2F2_HUMAN	POU2F2	physical	28514442
SCMC1_HUMAN	SLC25A24	physical	28514442
MTFP1_HUMAN	MTFP1	physical	28514442
SCMC3_HUMAN	SLC25A23	physical	28514442
SFXN5_HUMAN	SFXN5	physical	28514442
PDXD1_HUMAN	PDXDC1	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
KNTC1_HUMAN	KNTC1	physical	28514442
MAP2_HUMAN	METAP2	physical	28514442
ACD10_HUMAN	ACAD10	physical	28514442
BRAT1_HUMAN	BRAT1	physical	28514442
TBC9B_HUMAN	TBC1D9B	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
CAND2_HUMAN	CAND2	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.