dbPTM

SFXN5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SFXN5_HUMAN
UniProt AC	Q8TD22
Protein Name	Sideroflexin-5
Gene Name	SFXN5
Organism	Homo sapiens (Human).
Sequence Length	340
Subcellular Localization	Mitochondrion membrane Multi-pass membrane protein.
Protein Description	Transports citrate. Potential iron transporter (By similarity)..
Protein Sequence	MADTATTASAAAASAASASSDAPPFQLGKPRFQQTSFYGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLIQRFVPFPAVASANICNVVLMRYGELEEGIDVLDSDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	KPRFQQTSFYGRFRH CCCCCCCCHHHHHHH	16.48	24076635
89	Ubiquitination	EQLWSAQKIKQAILH HHHHCHHHHHHHHCC	52.14	-
117	Phosphorylation	SGYIPFGTPIVVGLL CCCCCCCCCEEEEEE	15.38	-
221	Phosphorylation	CNVVLMRYGELEEGI CCEEEECCCCHHCCE	10.86	-
319	Phosphorylation	QMSEIETSQLEPEIA CCHHCCHHHCCHHHH	21.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SFXN5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SFXN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SFXN5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LAMP2_HUMAN	LAMP2	physical	28514442
S6A15_HUMAN	SLC6A15	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
PPGB_HUMAN	CTSA	physical	28514442
BGAL_HUMAN	GLB1	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SFXN5_HUMAN

Related Literatures of Post-Translational Modification