dbPTM

ERC6L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ERC6L_HUMAN
UniProt AC	Q2NKX8
Protein Name	DNA excision repair protein ERCC-6-like
Gene Name	ERCC6L
Organism	Homo sapiens (Human).
Sequence Length	1250
Subcellular Localization	Chromosome, centromere . Chromosome, centromere, kinetochore . Chromosome . Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between
Protein Description	DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. [PubMed: 17218258 Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase]
Protein Sequence	MEASRRFPEAEALSPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVLSRIQKIQEALEELAEQGDDEFTDVCNSGLLLYRELHNQLFEHQKEGIAFLYSLYRDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVKEFIKWTPGMRVKTFHGPSKDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKSAICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPSLSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACCLLNLGTFSAQDGNEGEDSPDVDHIDQVTDDTLMEESGKMIFLMDLLKRLRDEGHQTLVFSQSRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQNSVTQLQLQSLHAAQRKSDIKLDEHIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLVEFESQNKEFLMEQQRTRNEGAWLREPVFPSSTKKKCPKLNKPQPQPSPLLSTHHTQEEDISSKMASVVIDDLPKEGEKQDLSSIKVNVTTLQDGKGTGSADSIATLPKGFGSVEELCTNSSLGMEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPEEVVVKAKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDISPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGSPQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLNNN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEASRRFPEAE ----CCHHHCCCHHH	27.55	26074081
14	Phosphorylation	FPEAEALSPEQAAHY CCHHHHCCHHHHHHH	33.18	25159151
21	Phosphorylation	SPEQAAHYLRYVKEA CHHHHHHHHHHHHHH	6.53	23403867
26	Ubiquitination	AHYLRYVKEAKEATK HHHHHHHHHHHHHHC	42.91	27667366
33	Ubiquitination	KEAKEATKNGDLEEA HHHHHHHCCCCHHHH	67.01	29967540
42	Ubiquitination	GDLEEAFKLFNLAKD CCHHHHHHHHHHHHH	60.25	29967540
48	Methylation	FKLFNLAKDIFPNEK HHHHHHHHHHCCCHH	55.30	23644510
48	Ubiquitination	FKLFNLAKDIFPNEK HHHHHHHHHHCCCHH	55.30	29967540
55	Methylation	KDIFPNEKVLSRIQK HHHCCCHHHHHHHHH	55.93	23644510
55	Ubiquitination	KDIFPNEKVLSRIQK HHHCCCHHHHHHHHH	55.93	22817900
116	Ubiquitination	SLYRDGRKGGILADD HHHHCCCCCCCEECC	68.00	29967540
166	Ubiquitination	TWVKEFIKWTPGMRV HHHHHHHHCCCCCCE	50.79	29967540
175	Phosphorylation	TPGMRVKTFHGPSKD CCCCCEEECCCCCCC	20.29	-
180	Phosphorylation	VKTFHGPSKDERTRN EEECCCCCCCHHHHH	58.28	-
185	Phosphorylation	GPSKDERTRNLNRIQ CCCCCHHHHHHHHHH	23.12	27174698
232	Acetylation	VILDEAHKIKTSSTK EEEECHHHCCCCCCC	53.60	25953088
235	Phosphorylation	DEAHKIKTSSTKSAI ECHHHCCCCCCCHHH	31.23	27461979
236	Phosphorylation	EAHKIKTSSTKSAIC CHHHCCCCCCCHHHH	30.89	27461979
237	Phosphorylation	AHKIKTSSTKSAICA HHHCCCCCCCHHHHH	45.12	27461979
238	Phosphorylation	HKIKTSSTKSAICAR HHCCCCCCCHHHHHH	28.87	27461979
239	Ubiquitination	KIKTSSTKSAICARA HCCCCCCCHHHHHHH	39.58	29967540
240	Phosphorylation	IKTSSTKSAICARAI CCCCCCCHHHHHHHC	23.97	27461979
287	Ubiquitination	LGTLKTFKMEYENPI HHHHHHHCEEECCCC	35.73	29967540
307	Ubiquitination	KDATPGEKALGFKIS CCCCCCCHHHCCCCC	55.62	29967540
312	Ubiquitination	GEKALGFKISENLMA CCHHHCCCCCHHHHH	43.45	-
322	Ubiquitination	ENLMAIIKPYFLRRT HHHHHHHHHHHHHHC	27.79	-
324	Phosphorylation	LMAIIKPYFLRRTKE HHHHHHHHHHHHCHH	15.39	20049867
329	Phosphorylation	KPYFLRRTKEDVQKK HHHHHHHCHHHHHHH	32.14	24719451
336	Ubiquitination	TKEDVQKKKSSNPEA CHHHHHHHHCCCCCH	40.57	24816145
337	Ubiquitination	KEDVQKKKSSNPEAR HHHHHHHHCCCCCHH	67.18	24816145
339	Phosphorylation	DVQKKKSSNPEARLN HHHHHHCCCCCHHHH	66.34	26546556
348	Ubiquitination	PEARLNEKNPDVDAI CCHHHHCCCCCHHHH	73.11	29967540
362	Phosphorylation	ICEMPSLSRKNDLII HHCCCCCCCCCCEEE	45.61	24260401
383	Ubiquitination	LQEEIYRKFVSLDHI CCHHHHHHHCCHHHH	32.90	22505724
391	Ubiquitination	FVSLDHIKELLMETR HCCHHHHHHHHHHCC	38.60	29967540
399	Phosphorylation	ELLMETRSPLAELGV HHHHHCCCHHHHHHH	31.52	25159151
408	Ubiquitination	LAELGVLKKLCDHPR HHHHHHHHHHCCCHH	41.09	29967540
409	Ubiquitination	AELGVLKKLCDHPRL HHHHHHHHHCCCHHH	50.62	29967540
418	Phosphorylation	CDHPRLLSARACCLL CCCHHHHHHHHHHHH	21.94	24719451
470	Ubiquitination	IFLMDLLKRLRDEGH HHHHHHHHHHHHCCC	57.60	-
479	Phosphorylation	LRDEGHQTLVFSQSR HHHCCCCEEEEECHH	21.15	29083192
483	Phosphorylation	GHQTLVFSQSRQILN CCCEEEEECHHHHHH	21.55	29083192
485	Phosphorylation	QTLVFSQSRQILNII CEEEEECHHHHHHHH	25.59	29083192
503	Phosphorylation	LKNRHFKTLRIDGTV HHCCCCCEEEECCHH	21.96	-
511	Phosphorylation	LRIDGTVTHLLEREK EEECCHHHHHHHHHH	13.47	23403867
576	Ubiquitination	RVYRIGQKENVVVYR HHHHCCCCCCEEEEE	46.15	-
593	Ubiquitination	TCGTVEEKIYRRQVF ECCCHHHHHHHHHHH	31.37	29967540
601	Ubiquitination	IYRRQVFKDSLIRQT HHHHHHHHHHHHHCC	47.77	24816145
603	Phosphorylation	RRQVFKDSLIRQTTG HHHHHHHHHHHCCCC	26.70	24719451
612	Ubiquitination	IRQTTGEKKNPFRYF HHCCCCCCCCCCCCC	60.23	29967540
618	Phosphorylation	EKKNPFRYFSKQELR CCCCCCCCCCHHHHH	16.75	-
621	Ubiquitination	NPFRYFSKQELRELF CCCCCCCHHHHHHHC	37.58	22505724
651	Ubiquitination	SLHAAQRKSDIKLDE HHHHHHHHHCCCHHH	40.16	29967540
694	Phosphorylation	ELDVVEESHYIQQRV HHHHHHHHHHHHHHH	14.21	28796482
696	Phosphorylation	DVVEESHYIQQRVQK HHHHHHHHHHHHHHH	15.09	28796482
703	Ubiquitination	YIQQRVQKAQFLVEF HHHHHHHHHHHHHEH	41.10	29967540
712	Phosphorylation	QFLVEFESQNKEFLM HHHHEHHHHCHHHHH	44.36	28555341
738	Phosphorylation	LREPVFPSSTKKKCP CCCCCCCCCCCCCCC	38.89	22199227
739	Phosphorylation	REPVFPSSTKKKCPK CCCCCCCCCCCCCCC	44.47	22199227
740	Phosphorylation	EPVFPSSTKKKCPKL CCCCCCCCCCCCCCC	51.74	21815630
741	Ubiquitination	PVFPSSTKKKCPKLN CCCCCCCCCCCCCCC	52.78	29967540
749	Malonylation	KKCPKLNKPQPQPSP CCCCCCCCCCCCCCC	56.30	26320211
749	Ubiquitination	KKCPKLNKPQPQPSP CCCCCCCCCCCCCCC	56.30	29967540
755	Phosphorylation	NKPQPQPSPLLSTHH CCCCCCCCCCCCCCC	23.96	25159151
759	Phosphorylation	PQPSPLLSTHHTQEE CCCCCCCCCCCCCHH	33.12	24732914
760	Phosphorylation	QPSPLLSTHHTQEED CCCCCCCCCCCCHHH	20.04	28555341
763	Phosphorylation	PLLSTHHTQEEDISS CCCCCCCCCHHHHHH	30.03	24732914
769	Phosphorylation	HTQEEDISSKMASVV CCCHHHHHHHHHHHH	35.91	24732914
770	Phosphorylation	TQEEDISSKMASVVI CCHHHHHHHHHHHHE	27.12	24732914
771	Ubiquitination	QEEDISSKMASVVID CHHHHHHHHHHHHEC	31.53	29967540
774	Phosphorylation	DISSKMASVVIDDLP HHHHHHHHHHECCCC	17.26	25159151
790	Phosphorylation	EGEKQDLSSIKVNVT CCCCCCHHHCEEEEE	38.00	22199227
791	Phosphorylation	GEKQDLSSIKVNVTT CCCCCHHHCEEEEEE	33.45	21815630
793	Ubiquitination	KQDLSSIKVNVTTLQ CCCHHHCEEEEEECC	29.70	29967540
797	Phosphorylation	SSIKVNVTTLQDGKG HHCEEEEEECCCCCC	19.31	30576142
798	Phosphorylation	SIKVNVTTLQDGKGT HCEEEEEECCCCCCC	20.38	25850435
803	Ubiquitination	VTTLQDGKGTGSADS EEECCCCCCCCCCHH	62.68	29967540
805	Phosphorylation	TLQDGKGTGSADSIA ECCCCCCCCCCHHEE	31.30	25159151
807	Phosphorylation	QDGKGTGSADSIATL CCCCCCCCCHHEEEC	28.83	29255136
810	Phosphorylation	KGTGSADSIATLPKG CCCCCCHHEEECCCC	17.53	29255136
813	Phosphorylation	GSADSIATLPKGFGS CCCHHEEECCCCCCC	41.76	25159151
816	Ubiquitination	DSIATLPKGFGSVEE HHEEECCCCCCCHHH	70.73	-
820	Phosphorylation	TLPKGFGSVEELCTN ECCCCCCCHHHHHHC	24.88	25159151
826	Phosphorylation	GSVEELCTNSSLGME CCHHHHHHCCCCCCC	51.24	23927012
828	Phosphorylation	VEELCTNSSLGMEKS HHHHHHCCCCCCCHH	14.58	25159151
829	Phosphorylation	EELCTNSSLGMEKSF HHHHHCCCCCCCHHH	30.89	25159151
835	Phosphorylation	SSLGMEKSFATKNEA CCCCCCHHHHCCCHH	13.55	21712546
838	Phosphorylation	GMEKSFATKNEAVQK CCCHHHHCCCHHHHH	32.18	21712546
847	Phosphorylation	NEAVQKETLQEGPKQ CHHHHHHHHCCCCCH	40.55	21406692
853	Ubiquitination	ETLQEGPKQEALQED HHHCCCCCHHHHHCC	72.18	29967540
864	Phosphorylation	LQEDPLESFNYVLSK HHCCCHHHHHHHHCC	26.86	25159151
867	Phosphorylation	DPLESFNYVLSKSTK CCHHHHHHHHCCCCC	10.76	28796482
870	Phosphorylation	ESFNYVLSKSTKADI HHHHHHHCCCCCCCC	17.95	28796482
871	Ubiquitination	SFNYVLSKSTKADIG HHHHHHCCCCCCCCC	58.97	29967540
872	Phosphorylation	FNYVLSKSTKADIGP HHHHHCCCCCCCCCC	31.59	18691976
873	Phosphorylation	NYVLSKSTKADIGPN HHHHCCCCCCCCCCC	33.71	29214152
874	Ubiquitination	YVLSKSTKADIGPNL HHHCCCCCCCCCCCH	51.67	29967540
885	Ubiquitination	GPNLDQLKDDEILRH CCCHHHCCHHHHHHH	58.46	29967540
905	Phosphorylation	IISITNESQNAESNV EEEEECCCCCCCCCC	30.70	19664994
913	Phosphorylation	QNAESNVSIIEIADD CCCCCCCEEEEEHHH	23.31	18691976
943	Phosphorylation	AKLEEEPSASSPQYA HHHHCCCCCCCCCEE	44.02	28731282
945	Phosphorylation	LEEEPSASSPQYACD HHCCCCCCCCCEEEE	47.06	25850435
946	Phosphorylation	EEEPSASSPQYACDF HCCCCCCCCCEEEEE	18.75	28731282
949	Phosphorylation	PSASSPQYACDFNLF CCCCCCCEEEEEEEE	16.75	29496963
968	Phosphorylation	ADNRQNFSSQSLEHV CCCCCCCCHHHHHHH	34.71	30266825
969	Phosphorylation	DNRQNFSSQSLEHVE CCCCCCCHHHHHHHH	21.46	30266825
971	Phosphorylation	RQNFSSQSLEHVEKE CCCCCHHHHHHHHHH	37.36	30266825
977	Ubiquitination	QSLEHVEKENSLCGS HHHHHHHHHCCCCCC	62.19	29967540
980	Phosphorylation	EHVEKENSLCGSAPN HHHHHHCCCCCCCCC	26.57	29255136
984	Phosphorylation	KENSLCGSAPNSRAG HHCCCCCCCCCCCCC	39.29	25159151
988	Phosphorylation	LCGSAPNSRAGFVHS CCCCCCCCCCCCEEE	23.58	22199227
995	Phosphorylation	SRAGFVHSKTCLSWE CCCCCEEECEEEEEE	25.10	17192257
997	Phosphorylation	AGFVHSKTCLSWEFS CCCEEECEEEEEECC	22.99	22199227
1000	Phosphorylation	VHSKTCLSWEFSEKD EEECEEEEEECCCCC	27.06	25159151
1004	Phosphorylation	TCLSWEFSEKDDEPE EEEEEECCCCCCCCC	32.02	25159151
1016	Ubiquitination	EPEEVVVKAKIRSKA CCCEEEEHHHHHHHH	32.14	29967540
1028	Phosphorylation	SKARRIVSDGEDEDD HHHHHHHCCCCCCCC	37.21	19664994
1036	Phosphorylation	DGEDEDDSFKDTSSI CCCCCCCCCCCCCCC	46.66	23927012
1038	Ubiquitination	EDEDDSFKDTSSINP CCCCCCCCCCCCCCC	65.14	29967540
1040	Phosphorylation	EDDSFKDTSSINPFN CCCCCCCCCCCCCCC	25.60	23898821
1041	Phosphorylation	DDSFKDTSSINPFNT CCCCCCCCCCCCCCC	39.08	30175587
1042	Phosphorylation	DSFKDTSSINPFNTS CCCCCCCCCCCCCCC	28.60	23898821
1048	Phosphorylation	SSINPFNTSLFQFSS CCCCCCCCCCCCCCC	27.47	26074081
1049	Phosphorylation	SINPFNTSLFQFSSV CCCCCCCCCCCCCCC	28.43	27050516
1054	Phosphorylation	NTSLFQFSSVKQFDA CCCCCCCCCCCEECC	24.36	26074081
1055	Phosphorylation	TSLFQFSSVKQFDAS CCCCCCCCCCEECCC	34.32	26074081
1062	Phosphorylation	SVKQFDASTPKNDIS CCCEECCCCCCCCCC	47.27	21712546
1063	Phosphorylation	VKQFDASTPKNDISP CCEECCCCCCCCCCC	39.75	21712546
1065	Ubiquitination	QFDASTPKNDISPPG EECCCCCCCCCCCCC	68.30	29967540
1069	Phosphorylation	STPKNDISPPGRFFS CCCCCCCCCCCCCCC	28.10	29255136
1076	Phosphorylation	SPPGRFFSSQIPSSV CCCCCCCCCCCCHHH	20.72	20068231
1077	Phosphorylation	PPGRFFSSQIPSSVN CCCCCCCCCCCHHHC	27.29	25159151
1081	Phosphorylation	FFSSQIPSSVNKSMN CCCCCCCHHHCHHHH	48.85	25159151
1082	Phosphorylation	FSSQIPSSVNKSMNS CCCCCCHHHCHHHHH	25.10	25159151
1085	Acetylation	QIPSSVNKSMNSRRS CCCHHHCHHHHHCHH	49.26	25953088
1085	Ubiquitination	QIPSSVNKSMNSRRS CCCHHHCHHHHHCHH	49.26	29967540
1086	Phosphorylation	IPSSVNKSMNSRRSL CCHHHCHHHHHCHHH	20.28	26055452
1089	Phosphorylation	SVNKSMNSRRSLASR HHCHHHHHCHHHHHH	22.04	21712546
1098	Phosphorylation	RSLASRRSLINMVLD HHHHHHHHHHHHHHH	32.27	25159151
1102	Ubiquitination	SRRSLINMVLDHVED HHHHHHHHHHHHHHH	2.22	32015554
1117	Phosphorylation	MEERLDDSSEAKGPE HHHHCCCCCCCCCCC	29.73	29978859
1118	Phosphorylation	EERLDDSSEAKGPED HHHCCCCCCCCCCCC	48.87	29978859
1126	Phosphorylation	EAKGPEDYPEEGVEE CCCCCCCCCCCCCCC	15.75	30576142
1134	Phosphorylation	PEEGVEESSGEASKY CCCCCCCCCCCHHHC	30.09	25159151
1135	Phosphorylation	EEGVEESSGEASKYT CCCCCCCCCCHHHCC	43.88	25159151
1139	Phosphorylation	EESSGEASKYTEEDP CCCCCCHHHCCCCCC	23.15	23663014
1141	Phosphorylation	SSGEASKYTEEDPSG CCCCHHHCCCCCCCC	19.52	30576142
1142	Phosphorylation	SGEASKYTEEDPSGE CCCHHHCCCCCCCCC	36.31	21406692
1147	Phosphorylation	KYTEEDPSGETLSSE HCCCCCCCCCCCCCC	62.68	21406692
1150	Phosphorylation	EEDPSGETLSSENKS CCCCCCCCCCCCCCC	35.15	30576142
1152	Phosphorylation	DPSGETLSSENKSSW CCCCCCCCCCCCCCC	42.92	25159151
1153	Phosphorylation	PSGETLSSENKSSWL CCCCCCCCCCCCCCC	48.58	25159151
1156	Methylation	ETLSSENKSSWLMTS CCCCCCCCCCCCCCC	41.64	-
1158	Phosphorylation	LSSENKSSWLMTSKP CCCCCCCCCCCCCCH	26.32	27251275
1166	Phosphorylation	WLMTSKPSALAQETS CCCCCCHHHHHHCCC	39.38	26074081
1172	Phosphorylation	PSALAQETSLGAPEP HHHHHHCCCCCCCCC	19.71	18691976
1173	Phosphorylation	SALAQETSLGAPEPL HHHHHCCCCCCCCCC	24.85	25159151
1181	Phosphorylation	LGAPEPLSGEQLVGS CCCCCCCCCCCCCCC	51.50	25159151
1188	Phosphorylation	SGEQLVGSPQDKAAE CCCCCCCCHHHHHHH	16.35	25159151
1197	Phosphorylation	QDKAAEATNDYETLV HHHHHHHCCHHHHHH	21.81	26074081
1200	Phosphorylation	AAEATNDYETLVKRG HHHHCCHHHHHHHHC	16.94	28796482
1202	Phosphorylation	EATNDYETLVKRGKE HHCCHHHHHHHHCHH	30.53	28796482
1205	Ubiquitination	NDYETLVKRGKELKE CHHHHHHHHCHHHHH	59.55	29967540
1225	Ubiquitination	EALNCLVKALDIKSA HHHHHHHHHHCCCCC	30.22	32015554
1240	Phosphorylation	DPEVMLLTLSLYKQL CHHHHHHHHHHHHHH	15.44	26270265
1242	Phosphorylation	EVMLLTLSLYKQLNN HHHHHHHHHHHHHHC	25.15	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1063	T	Phosphorylation	Kinase	CDK1	P06493	PSP
1063	T	Phosphorylation	Kinase	PLK1	P53350	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ERC6L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ERC6L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBCC1_HUMAN	RB1CC1	physical	17353931
RFA3_HUMAN	RPA3	physical	17353931
IF4B_HUMAN	EIF4B	physical	26496610
LDHA_HUMAN	LDHA	physical	26496610
PLK1_HUMAN	PLK1	physical	26496610
PLK1_HUMAN	PLK1	physical	28514442
SIX1_HUMAN	SIX1	physical	28514442
MIDN_HUMAN	MIDN	physical	28514442
CHK1_HUMAN	CHEK1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ERC6L_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1028 AND SER-1098, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-755, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-820; SER-1028; SER-1135AND SER-1188, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-774; SER-807;SER-810; THR-813; SER-820; SER-1028 AND SER-1069, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-755; SER-774;THR-805; SER-807; SER-810; SER-820; THR-826; SER-828; SER-829;SER-968; SER-969; SER-971; SER-980; SER-984; SER-995; SER-1000;SER-1004; SER-1028; SER-1036; THR-1040; SER-1041; SER-1042; SER-1069;SER-1098; SER-1181 AND SER-1188, AND MASS SPECTROMETRY.	18691976 [Abstract]
"PICH, a centromere-associated SNF2 family ATPase, is regulated byPlk1 and required for the spindle checkpoint."; Baumann C., Koerner R., Hofmann K., Nigg E.A.; Cell 128:101-114(2007). Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION,PHOSPHORYLATION AT THR-1063, INTERACTION WITH PLK1, AND MUTAGENESIS OF127-GLY--THR-129 AND THR-1063.	17218258 [Abstract]