SIX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIX1_HUMAN
• UniProt AC: Q15475
• Protein Name: Homeobox protein SIX1
• Gene Name: SIX1
• Organism: Homo sapiens (Human).
• Sequence Length: 284
• Subcellular Localization: Nucleus . Cytoplasm.
• Protein Description: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1..
• Protein Sequence: MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQGNMGHARSSNYSLPGLTASQPSHGLQTHQHQLQDSLLGPLTSSLVDLGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSMLPSFGFTQEQ --CCCCCCCCCCHHH	33.76	29759185
10	Phosphorylation	MLPSFGFTQEQVACV CCCCCCCCHHHHHHH	31.41	29759185
53	Ubiquitination	NESVLKAKAVVAFHR CCHHHHHHHHEEECC	39.88	-
76	Phosphorylation	ILESHQFSPHNHPKL HHHHCCCCCCCCHHH	20.76	28555341
97	Ubiquitination	AHYVEAEKLRGRPLG HHHHHHHHHCCCCCC	51.00	29967540
143	Phosphorylation	RGVLREWYAHNPYPS CCHHHHHHHHCCCCC	8.01	-
148	Phosphorylation	EWYAHNPYPSPREKR HHHHHCCCCCHHHHH	22.97	27080861
150	Phosphorylation	YAHNPYPSPREKREL HHHCCCCCHHHHHHH	30.64	25159151
164	Phosphorylation	LAEATGLTTTQVSNW HHHHHCCCHHHHHHH	29.19	-
204	Phosphorylation	SNKQNQLSPLEGGKP CCCCCCCCCCCCCCC	20.06	25159151
215	Phosphorylation	GGKPLMSSSEEEFSP CCCCCCCCCCCCCCC	28.01	27251275
216	Phosphorylation	GKPLMSSSEEEFSPP CCCCCCCCCCCCCCC	41.54	27251275
276	O-linked_Glycosylation	DSLLGPLTSSLVDLG HHHHHHHHHHHHHCC	21.28	32863962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC85B_HUMAN	CCDC85B	physical	16189514
EYA2_HUMAN	EYA2	physical	10906137
FZR1_HUMAN	FZR1	physical	17130831
VTNC_HUMAN	VTN	physical	21988832
EYA4_HUMAN	EYA4	physical	26186194
EYA1_HUMAN	EYA1	physical	26186194
MYH3_HUMAN	MYH3	physical	26186194
MYH7_HUMAN	MYH7	physical	26186194
MYH4_HUMAN	MYH4	physical	26186194
EYA1_HUMAN	EYA1	physical	28514442
EYA4_HUMAN	EYA4	physical	28514442
MYH3_HUMAN	MYH3	physical	28514442
MYH4_HUMAN	MYH4	physical	28514442
MYH7_HUMAN	MYH7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.