EYA2_HUMAN - dbPTM
EYA2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EYA2_HUMAN
UniProt AC O00167
Protein Name Eyes absent homolog 2
Gene Name EYA2
Organism Homo sapiens (Human).
Sequence Length 538
Subcellular Localization Cytoplasm . Nucleus . Retained in the cytoplasm via interaction with GNAZ and GNAI2 (PubMed:10906137). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (PubMed:10906137, PubMed:12500905).
Protein Description Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. [PubMed: 12500905]
Protein Sequence MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
98PhosphorylationAQAYGIPSYSIKTED
HHHCCCCCCEEECCC		29.5926091039
100PhosphorylationAYGIPSYSIKTEDSL
HCCCCCCEEECCCCC		23.1924719451
256PhosphorylationLRGRSKRSSDPSPAG
CCCCCCCCCCCCCCC		42.7122985185
257PhosphorylationRGRSKRSSDPSPAGD
CCCCCCCCCCCCCCC		58.5429507054
296UbiquitinationTFASRYGKDTTTSVR
CHHHHCCCCCCCHHH		42.86-
404PhosphorylationNVGGLIGTPKRETWL
CCCCCCCCCCHHHHH		20.7421712546
461PhosphorylationALAKVLLYGLGSVFP
HHHHHHHHCCCCCCC		13.2225072903
465PhosphorylationVLLYGLGSVFPIENI
HHHHCCCCCCCHHHH		26.1525072903
473PhosphorylationVFPIENIYSATKTGK
CCCHHHHHHCCCCCH		12.1125072903
474PhosphorylationFPIENIYSATKTGKE
CCHHHHHHCCCCCHH		26.1825072903
476PhosphorylationIENIYSATKTGKESC
HHHHHHCCCCCHHHH		24.1725072903
480UbiquitinationYSATKTGKESCFERI
HHCCCCCHHHHHHHH		52.24-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EYA2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EYA2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EYA2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DMRTB_HUMANDMRTB1physical
16189514
RBPMS_HUMANRBPMSphysical
16189514
SIX4_HUMANSIX4physical
10490620
GNAI2_HUMANGNAI2physical
10906137
GNAZ_HUMANGNAZphysical
10906137
SIX1_HUMANSIX1physical
21516116
SIX4_HUMANSIX4physical
27880917
ZN609_HUMANZNF609physical
27880917
TRPS1_HUMANTRPS1physical
27880917
NCOR2_HUMANNCOR2physical
27880917
CING_HUMANCGNphysical
27880917
ARI1A_HUMANARID1Aphysical
27880917
ARI1B_HUMANARID1Bphysical
27880917
KMT2D_HUMANKMT2Dphysical
27880917
BCOR_HUMANBCORphysical
27880917
NCOR1_HUMANNCOR1physical
27880917
AP2A_HUMANTFAP2Aphysical
27880917
GSE1_HUMANGSE1physical
27880917
CEP85_HUMANCEP85physical
27880917
TLE3_HUMANTLE3physical
27880917
RBM20_HUMANRBM20physical
27880917
KDM6A_HUMANKDM6Aphysical
27880917
PRC2B_HUMANPRRC2Bphysical
27880917
TNR6A_HUMANTNRC6Aphysical
27880917
RAVR1_HUMANRAVER1physical
27880917
SC16A_HUMANSEC16Aphysical
27880917
PUM1_HUMANPUM1physical
27880917
CIC_HUMANCICphysical
27880917
CCD18_HUMANCCDC18physical
27880917
SDCG3_HUMANSDCCAG3physical
27880917
KIF14_HUMANKIF14physical
27880917
CNOT1_HUMANCNOT1physical
27880917
LZTS2_HUMANLZTS2physical
27880917
AGO2_HUMANAGO2physical
27880917
NBN_HUMANNBNphysical
27880917
BAG3_HUMANBAG3physical
27880917
TGO1_HUMANMIA3physical
27880917
EYA2_HUMANEYA2physical
27432908
THEM6_HUMANTHEM6physical
27432908
PHKG2_HUMANPHKG2physical
27432908
CGRF1_HUMANCGRRF1physical
27432908
TMEM9_HUMANTMEM9physical
27432908
KPBB_HUMANPHKBphysical
27432908
ANFC_HUMANNPPCphysical
27432908
KPB2_HUMANPHKA2physical
27432908
DUS1_HUMANDUSP1physical
27432908
GPX8_HUMANGPX8physical
27432908
FAM3A_HUMANFAM3Aphysical
27432908
NDUF3_HUMANNDUFAF3physical
27432908
NDUF4_HUMANNDUFAF4physical
27432908
GMPPB_HUMANGMPPBphysical
27432908
TMCO1_HUMANTMCO1physical
27432908
DCD_HUMANDCDphysical
27432908
KPB1_HUMANPHKA1physical
27432908
CY1_HUMANCYC1physical
27432908
NDUA9_HUMANNDUFA9physical
27432908
GBB2_HUMANGNB2physical
27432908
PIGT_HUMANPIGTphysical
27432908
CC28A_HUMANCCDC28Aphysical
27432908
GDAP1_HUMANGDAP1physical
27432908
QPCTL_HUMANQPCTLphysical
27432908
TIM21_HUMANTIMM21physical
27432908
ETFB_HUMANETFBphysical
27432908
SCO1_HUMANSCO1physical
27432908
ACAD9_HUMANACAD9physical
27432908
ARK72_HUMANAKR7A2physical
27432908
DCA11_HUMANDCAF11physical
27432908
NDKA_HUMANNME1physical
27432908
IDE_HUMANIDEphysical
27432908
DJB12_HUMANDNAJB12physical
27432908
GMPPA_HUMANGMPPAphysical
27432908
MAIP1_HUMANC2orf47physical
27432908
OXA1L_HUMANOXA1Lphysical
27432908
PNKD_HUMANPNKDphysical
27432908
VAPB_HUMANVAPBphysical
27432908
CC85C_HUMANCCDC85Cphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EYA2_HUMAN

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Related Literatures of Post-Translational Modification

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