GPX8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPX8_HUMAN
• UniProt AC: Q8TED1
• Protein Name: Probable glutathione peroxidase 8
• Gene Name: GPX8
• Organism: Homo sapiens (Human).
• Sequence Length: 209
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWKPEEPIEVIRPDIAALVRQVIIKKKEDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPLAAYP -------CCCCCCCC	12.35	22814378
10	Ubiquitination	PLAAYPLKCSGPRAK CCCCCCCCCCCHHHH	23.11	-
53	Ubiquitination	SFYAFEVKDAKGRTV EEEEEEEECCCCCEE	44.78	-
61	Phosphorylation	DAKGRTVSLEKYKGK CCCCCEEEEEEECCE	30.14	27251275
64	Ubiquitination	GRTVSLEKYKGKVSL CCEEEEEEECCEEEE	58.52	-
90	Ubiquitination	DRNYLGLKELHKEFG CCCCCCHHHHHHHHC	57.33	-
90	Acetylation	DRNYLGLKELHKEFG CCCCCCHHHHHHHHC	57.33	27452117
94	Ubiquitination	LGLKELHKEFGPSHF CCHHHHHHHHCCCCE	68.32	-
94	Acetylation	LGLKELHKEFGPSHF CCHHHHHHHHCCCCE	68.32	26051181
120	Ubiquitination	ESEPRPSKEVESFAR CCCCCCCHHHHHHHH	69.34	-
128	Ubiquitination	EVESFARKNYGVTFP HHHHHHHHHCCCCCE	51.60	21890473
130	Phosphorylation	ESFARKNYGVTFPIF HHHHHHHCCCCCEEE	18.93	28152594
141	Ubiquitination	FPIFHKIKILGSEGE CEEEEEEEEECCCCC	36.36	-
159	Ubiquitination	RFLVDSSKKEPRWNF EHEECCCCCCCCCCH	66.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPX8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPX8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPX8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3PT_HUMAN	GAPDHS	physical	26186194
G3PT_HUMAN	GAPDHS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione