RBM20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBM20_HUMAN
• UniProt AC: Q5T481
• Protein Name: RNA-binding protein 20
• Gene Name: RBM20
• Organism: Homo sapiens (Human).
• Sequence Length: 1227
• Subcellular Localization: Nucleus .
• Protein Description: RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin)..
• Protein Sequence: MVLAAAMSQDADPSGPEQPDRVACSVPGARASPAPSGPRGMQQPPPPPQPPPPPQAGLPQIIQNAAKLLDKNPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSVITGPHGHAGVPQHAAAIPSTRFPSNAIAFSPPSQTRGPGPSMNLPNQPPSAMVMHPFTGVMPQTPGQPAVILGIGKTGPAPATAGFYEYGKASSGQTYGPETDGQPGFLPSSASTSGSVTYEGHYSHTGQDGQAAFSKDFYGPNSQGSHVASGFPAEQAGGLKSEVGPLLQGTNSQWESPHGFSGQSKPDLTAGPMWPPPHNQPYELYDPEEPTSDRTPPSFGGRLNNSKQGFIGAGRRAKEDQALLSVRPLQAHELNDFHGVAPLHLPHICSICDKKVFDLKDWELHVKGKLHAQKCLVFSENAGIRCILGSAEGTLCASPNSTAVYNPAGNEDYASNLGTSYVPIPARSFTQSSPTFPLASVGTTFAQRKGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQEKSAVINGEKLLIRMSKRYKELQLKKPGKAVAAIIQDIHSQRERDMFREADRYGPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARREEERDPAPWRDNGDDKRDRMDPWAHDRKHHPRQLDKAELDERPEGGRPHREKYPRSGSPNLPHSVSSYKSREDGYYRKEPKAKWDKYLKQQQDAPGRSRRKDEARLRESRHPHPDDSGKEDGLGPKVTRAPEGAKAKQNEKNKTKRTDRDQEGADDRKENTMAENEAGKEEQEGMEESPQSVGRQEKEAEFSDPENTRTKKEQDWESESEAEGESWYPTNMEELVTVDEVGEEEDFIVEPDIPELEEIVPIDQKDKICPETCLCVTTTLDLDLAQDFPKEGVKAVGNGAAEISLKSPRELPSASTSCPSDMDVEMPGLNLDAERKPAESETGLSLEDSDCYEKEAKGVESSDVHPAPTVQQMSSPKPAEERARQPSPFVDDCKTRGTPEDGACEGSPLEEKASPPIETDLQNQACQEVLTPENSRYVEMKSLEVRSPEYTEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEETAKMSHCRSAVHYRNLQKYLSQLAEEGLKETEGADSPRPEDSGIVPRFERKKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	SVPGARASPAPSGPR CCCCCCCCCCCCCCC	18.95	23403867
36	Phosphorylation	ARASPAPSGPRGMQQ CCCCCCCCCCCCCCC	64.63	23403867
200	Phosphorylation	AMVMHPFTGVMPQTP CEEECCCCCCCCCCC	33.06	23532336
225	Phosphorylation	KTGPAPATAGFYEYG CCCCCCCCCCHHHCC	26.67	28176443
229	Phosphorylation	APATAGFYEYGKASS CCCCCCHHHCCCCCC	13.81	28176443
231	Phosphorylation	ATAGFYEYGKASSGQ CCCCHHHCCCCCCCC	16.73	28176443
244	Ubiquitination	GQTYGPETDGQPGFL CCCCCCCCCCCCCCC	48.87	27667366
287	Phosphorylation	KDFYGPNSQGSHVAS CCCCCCCCCCCCCCC	38.77	28555341
317	Ubiquitination	PLLQGTNSQWESPHG HHCCCCCCCCCCCCC	36.19	27667366
360	Phosphorylation	EEPTSDRTPPSFGGR CCCCCCCCCCCCCCC	44.54	-
363	Phosphorylation	TSDRTPPSFGGRLNN CCCCCCCCCCCCCCC	37.41	-
372	Ubiquitination	GGRLNNSKQGFIGAG CCCCCCCCCCCCCCC	57.47	27667366
493	Phosphorylation	YVPIPARSFTQSSPT CCCCCCCCCCCCCCC	34.45	26434776
495	Phosphorylation	PIPARSFTQSSPTFP CCCCCCCCCCCCCCC	28.87	26434776
497	Phosphorylation	PARSFTQSSPTFPLA CCCCCCCCCCCCCCC	34.92	27732954
498	Phosphorylation	ARSFTQSSPTFPLAS CCCCCCCCCCCCCCC	20.38	27732954
500	Phosphorylation	SFTQSSPTFPLASVG CCCCCCCCCCCCCCC	39.57	27732954
505	Phosphorylation	SPTFPLASVGTTFAQ CCCCCCCCCCCCHHH	28.85	26434776
508	Phosphorylation	FPLASVGTTFAQRKG CCCCCCCCCHHHCCC	19.31	26434776
509	Phosphorylation	PLASVGTTFAQRKGA CCCCCCCCHHHCCCC	15.85	23312004
514	Ubiquitination	GTTFAQRKGAGRVVH CCCHHHCCCCCCEEE	40.82	-
544	Sumoylation	NLGLPFGKVTNYILM ECCCCCCHHHHEEEE	46.39	-
574	Phosphorylation	AQAMVQYYQEKSAVI HHHHHHHHHHHHHHH	7.97	24275569
585	Acetylation	SAVINGEKLLIRMSK HHHHCCHHHHHHHHH	50.41	7340171
592	Acetylation	KLLIRMSKRYKELQL HHHHHHHHHHHHHCC	50.86	51503251
594	Phosphorylation	LIRMSKRYKELQLKK HHHHHHHHHHHCCCC	16.73	-
635	Phosphorylation	YGPERPRSRSPVSRS HCCCCCCCCCCCCCC	39.53	23186163
637	Phosphorylation	PERPRSRSPVSRSLS CCCCCCCCCCCCCCC	30.79	23186163
640	Phosphorylation	PRSRSPVSRSLSPRS CCCCCCCCCCCCCCC	21.38	29449344
642	Phosphorylation	SRSPVSRSLSPRSHT CCCCCCCCCCCCCCC	26.20	23927012
644	Phosphorylation	SPVSRSLSPRSHTPS CCCCCCCCCCCCCCC	21.36	30278072
647	Phosphorylation	SRSLSPRSHTPSFTS CCCCCCCCCCCCCCC	34.79	27732954
649	Phosphorylation	SLSPRSHTPSFTSCS CCCCCCCCCCCCCCC	23.13	28555341
651	Phosphorylation	SPRSHTPSFTSCSSS CCCCCCCCCCCCCCC	42.16	28857561
653	Phosphorylation	RSHTPSFTSCSSSHS CCCCCCCCCCCCCCC	32.91	28857561
654	Phosphorylation	SHTPSFTSCSSSHSP CCCCCCCCCCCCCCC	15.25	28857561
656	Phosphorylation	TPSFTSCSSSHSPPG CCCCCCCCCCCCCCC	34.34	30278072
657	Phosphorylation	PSFTSCSSSHSPPGP CCCCCCCCCCCCCCC	36.08	20363803
658	Phosphorylation	SFTSCSSSHSPPGPS CCCCCCCCCCCCCCC	16.22	24117733
660	Phosphorylation	TSCSSSHSPPGPSRA CCCCCCCCCCCCCCC	34.44	30278072
665	Phosphorylation	SHSPPGPSRADWGNG CCCCCCCCCCCCCCC	46.12	24117733
679	Phosphorylation	GRDSWEHSPYARREE CCCCCCCCCCCCCHH	14.21	27732954
681	Phosphorylation	DSWEHSPYARREEER CCCCCCCCCCCHHHC	18.76	23186163
737	Phosphorylation	GRPHREKYPRSGSPN CCCCCHHCCCCCCCC	10.10	30576142
740	Phosphorylation	HREKYPRSGSPNLPH CCHHCCCCCCCCCCC	38.83	30278072
742	Phosphorylation	EKYPRSGSPNLPHSV HHCCCCCCCCCCCCH	16.32	30278072
748	Phosphorylation	GSPNLPHSVSSYKSR CCCCCCCCHHHCCCC	23.04	28555341
750	Phosphorylation	PNLPHSVSSYKSRED CCCCCCHHHCCCCCC	30.85	26434776
751	Phosphorylation	NLPHSVSSYKSREDG CCCCCHHHCCCCCCC	34.13	30576142
801	Phosphorylation	RHPHPDDSGKEDGLG CCCCCCCCCCCCCCC	60.18	28985074
810	Acetylation	KEDGLGPKVTRAPEG CCCCCCCCCCCCCCH	55.21	7710347
831	Phosphorylation	EKNKTKRTDRDQEGA HCCCCCCCCHHHCCH	36.62	-
845	Phosphorylation	ADDRKENTMAENEAG HHHHHHHHHHHHHHH	20.89	20363803
862	Phosphorylation	EQEGMEESPQSVGRQ HHCCCCCCCCCCCHH	18.22	20363803
865	Phosphorylation	GMEESPQSVGRQEKE CCCCCCCCCCHHHHH	29.89	20363803
876	Phosphorylation	QEKEAEFSDPENTRT HHHHHHCCCCCCCCC	43.70	19664994
881	Phosphorylation	EFSDPENTRTKKEQD HCCCCCCCCCCCHHC	37.75	23186163
883	Phosphorylation	SDPENTRTKKEQDWE CCCCCCCCCCHHCCC	44.42	28102081
963	Sumoylation	DLAQDFPKEGVKAVG HHHHHCCHHCEEEEC	68.07	-
963	Sumoylation	DLAQDFPKEGVKAVG HHHHHCCHHCEEEEC	68.07	-
977	Phosphorylation	GNGAAEISLKSPREL CCCCEEEECCCCCCC	22.65	29978859
980	Phosphorylation	AAEISLKSPRELPSA CEEEECCCCCCCCCC	34.19	22617229
986	Phosphorylation	KSPRELPSASTSCPS CCCCCCCCCCCCCCC	47.69	27732954
988	Phosphorylation	PRELPSASTSCPSDM CCCCCCCCCCCCCCC	25.78	27732954
989	Phosphorylation	RELPSASTSCPSDMD CCCCCCCCCCCCCCC	33.78	27732954
990	Phosphorylation	ELPSASTSCPSDMDV CCCCCCCCCCCCCCC	22.87	27732954
993	Phosphorylation	SASTSCPSDMDVEMP CCCCCCCCCCCCCCC	50.31	27732954
1013	Phosphorylation	AERKPAESETGLSLE CCCCCCCCCCCCCCC	42.43	27732954
1015	Phosphorylation	RKPAESETGLSLEDS CCCCCCCCCCCCCCC	53.34	27732954
1018	Phosphorylation	AESETGLSLEDSDCY CCCCCCCCCCCCHHH	30.93	27732954
1022	Phosphorylation	TGLSLEDSDCYEKEA CCCCCCCCHHHHHHC	21.87	29214152
1025	Phosphorylation	SLEDSDCYEKEAKGV CCCCCHHHHHHCCCC	34.72	27732954
1042	Phosphorylation	SDVHPAPTVQQMSSP CCCCCCCCHHHCCCC	32.81	28985074
1047	Phosphorylation	APTVQQMSSPKPAEE CCCHHHCCCCCCHHH	38.87	21082442
1048	Phosphorylation	PTVQQMSSPKPAEER CCHHHCCCCCCHHHH	31.44	22617229
1060	Phosphorylation	EERARQPSPFVDDCK HHHHCCCCCCCCCCC	23.72	30278072
1068	Phosphorylation	PFVDDCKTRGTPEDG CCCCCCCCCCCCCCC	40.43	28985074
1071	Phosphorylation	DDCKTRGTPEDGACE CCCCCCCCCCCCCCC	21.88	27732954
1080	Phosphorylation	EDGACEGSPLEEKAS CCCCCCCCCCCCCCC	12.20	30278072
1087	Phosphorylation	SPLEEKASPPIETDL CCCCCCCCCCCCHHH	42.13	27732954
1092	Phosphorylation	KASPPIETDLQNQAC CCCCCCCHHHHCHHH	42.61	27732954
1104	Phosphorylation	QACQEVLTPENSRYV HHHHHHCCCCCCCCE	33.46	27732954
1108	Phosphorylation	EVLTPENSRYVEMKS HHCCCCCCCCEEEEE	24.27	27732954
1115	Phosphorylation	SRYVEMKSLEVRSPE CCCEEEEEEEECCCC	28.58	20363803
1120	Phosphorylation	MKSLEVRSPEYTEVE EEEEEECCCCCEEEE	27.53	19664994
1123	Phosphorylation	LEVRSPEYTEVELKQ EEECCCCCEEEEEEC	16.16	22496350
1124	Phosphorylation	EVRSPEYTEVELKQP EECCCCCEEEEEECC	31.71	29978859
1162	Phosphorylation	VVPRTGFYCKLCGLF EECCCCCEEHHCCCE	7.04	25884760
1164	Methylation	PRTGFYCKLCGLFYT CCCCCEEHHCCCEEC	35.12	-
1205	Phosphorylation	AEEGLKETEGADSPR HHHHHHHCCCCCCCC	37.82	27732954
1210	Phosphorylation	KETEGADSPRPEDSG HHCCCCCCCCCCCCC	23.44	27732954
1216	Phosphorylation	DSPRPEDSGIVPRFE CCCCCCCCCCCCCCC	28.85	30177828

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBM20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBM20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBM20_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RBM20_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613172: Cardiomyopathy, dilated 1DD (CMD1DD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1080, AND MASSSPECTROMETRY.
PubMed: 19413330