| UniProt ID | PKHB1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UF11 | |
| Protein Name | Pleckstrin homology domain-containing family B member 1 | |
| Gene Name | PLEKHB1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 243 | |
| Subcellular Localization | Membrane . Cytoplasm . Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated (PubMed:10585447). Highly expressed in the outer segments of photoreceptor cells, both in rods and cones (PubMed:10585447) | |
| Protein Description | ||
| Protein Sequence | MSPAAPVPPDSALESPFEEMALVRGGWLWRQSSILRRWKRNWFALWLDGTLGYYHDETAQDEEDRVLIHFNVRDIKIGPECHDVQPPEGRSRDGLLTVNLREGGRLHLCAETKDDALAWKTALLEANSTPAPAGATVPPRSRRVCSKVRCVTRSWSPCKVERRIWVRVYSPYQDYYEVVPPNAHEATYVRSYYGPPYAGPGVTHVIVREDPCYSAGAPLAMGMLAGAATGAALGSLMWSPCWF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | Phosphorylation | GWLWRQSSILRRWKR CCHHHHHHHHHHHHH | 19.80 | 24719451 | |
| 110 (in isoform 4) | Phosphorylation | - | 33.58 | 24076635 | |
| 121 | Phosphorylation | DDALAWKTALLEANS CCHHHHHHHHHHCCC | 16.31 | 30624053 | |
| 128 | Phosphorylation | TALLEANSTPAPAGA HHHHHCCCCCCCCCC | 42.70 | 28857561 | |
| 129 (in isoform 2) | Phosphorylation | - | 24.23 | 24076635 | |
| 129 | Phosphorylation | ALLEANSTPAPAGAT HHHHCCCCCCCCCCC | 24.23 | 28857561 | |
| 136 | Phosphorylation | TPAPAGATVPPRSRR CCCCCCCCCCCHHHH | 32.40 | 28857561 | |
| 156 | Phosphorylation | RCVTRSWSPCKVERR EEEECCCCCCEEEEE | 22.97 | 24076635 | |
| 170 | Phosphorylation | RIWVRVYSPYQDYYE EEEEEEECCCCCEEE | 17.80 | 24076635 | |
| 175 | Phosphorylation | VYSPYQDYYEVVPPN EECCCCCEEECCCCC | 5.99 | 22817900 | |
| 176 | Phosphorylation | YSPYQDYYEVVPPNA ECCCCCEEECCCCCC | 15.55 | 22817900 | |
| 187 | Phosphorylation | PPNAHEATYVRSYYG CCCCHHCCEEEEECC | 21.40 | 27642862 | |
| 188 | Phosphorylation | PNAHEATYVRSYYGP CCCHHCCEEEEECCC | 10.83 | 22817900 | |
| 191 | Phosphorylation | HEATYVRSYYGPPYA HHCCEEEEECCCCCC | 16.80 | 28796482 | |
| 192 | Phosphorylation | EATYVRSYYGPPYAG HCCEEEEECCCCCCC | 11.24 | 28796482 | |
| 193 | Phosphorylation | ATYVRSYYGPPYAGP CCEEEEECCCCCCCC | 25.14 | 28796482 | |
| 197 | Phosphorylation | RSYYGPPYAGPGVTH EEECCCCCCCCCEEE | 27.59 | 28796482 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PKHB1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PKHB1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PKHB1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SH22A_HUMAN | SH2D2A | physical | 25814554 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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