AL7A1_HUMAN - dbPTM
AL7A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AL7A1_HUMAN
UniProt AC P49419
Protein Name Alpha-aminoadipic semialdehyde dehydrogenase
Gene Name ALDH7A1
Organism Homo sapiens (Human).
Sequence Length 539
Subcellular Localization Cytoplasm, cytosol . Nucleus .
Isoform 1: Mitochondrion .
Protein Description Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism..
Protein Sequence MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 2)Acetylation-15.5419413330
23 (in isoform 4)Phosphorylation-31.36-
30PhosphorylationSRPAAFMSTLLINQP
CCCHHHHHHHHHCCH		14.9525599653
30AcetylationSRPAAFMSTLLINQP
CCCHHHHHHHHHCCH		14.9519413330
39PhosphorylationLLINQPQYAWLKELG
HHHCCHHHHHHHHHC		13.36110745675
57AcetylationENEGVYNGSWGGRGE
CCCCCCCCCCCCCCE		13.6919413330
67PhosphorylationGGRGEVITTYCPANN
CCCCEEEEEEECCCC		19.5228152594
68PhosphorylationGRGEVITTYCPANNE
CCCEEEEEEECCCCC		16.4128152594
69PhosphorylationRGEVITTYCPANNEP
CCEEEEEEECCCCCC		6.4424927040
81UbiquitinationNEPIARVRQASVADY
CCCCHHHHHHHHHCH		22.3121890473
84PhosphorylationIARVRQASVADYEET
CHHHHHHHHHCHHHH		14.9725159151
88PhosphorylationRQASVADYEETVKKA
HHHHHHCHHHHHHHH		13.11110745683
932-HydroxyisobutyrylationADYEETVKKAREAWK
HCHHHHHHHHHHHHH		48.40-
93AcetylationADYEETVKKAREAWK
HCHHHHHHHHHHHHH		48.4023236377
93SuccinylationADYEETVKKAREAWK
HCHHHHHHHHHHHHH		48.4027452117
94AcetylationDYEETVKKAREAWKI
CHHHHHHHHHHHHHH		48.6330585379
94SuccinylationDYEETVKKAREAWKI
CHHHHHHHHHHHHHH		48.63-
94SuccinylationDYEETVKKAREAWKI
CHHHHHHHHHHHHHH		48.63-
100AcetylationKKAREAWKIWADIPA
HHHHHHHHHHCCCCC		35.1026051181
109UbiquitinationWADIPAPKRGEIVRQ
HCCCCCCCCCHHHHH		75.1321890473
1242-HydroxyisobutyrylationIGDALREKIQVLGSL
HHHHHHHHHHHHHHH		31.82-
130PhosphorylationEKIQVLGSLVSLEMG
HHHHHHHHHHHHHHC		22.8020068231
133PhosphorylationQVLGSLVSLEMGKIL
HHHHHHHHHHHCCEE		24.7320068231
136UbiquitinationGSLVSLEMGKILVEG
HHHHHHHHCCEEEEC		8.8721890473
136SulfoxidationGSLVSLEMGKILVEG
HHHHHHHHCCEEEEC		8.8730846556
163SulfoxidationYAVGLSRMIGGPILP
HHHHHHHHHCCCCCC		2.7630846556
171PhosphorylationIGGPILPSERSGHAL
HCCCCCCCCCCCCHH		42.0421406692
222PhosphorylationCLWKGAPTTSLISVA
EECCCCCCHHHHHHH		28.6021406692
223PhosphorylationLWKGAPTTSLISVAV
ECCCCCCHHHHHHHH		22.0721406692
224PhosphorylationWKGAPTTSLISVAVT
CCCCCCHHHHHHHHH		26.6121406692
227PhosphorylationAPTTSLISVAVTKII
CCCHHHHHHHHHHHH		14.8721406692
231PhosphorylationSLISVAVTKIIAKVL
HHHHHHHHHHHHHHH		13.5421406692
249PhosphorylationKLPGAICSLTCGGAD
CCCCCEEECEECCCC		22.1721406692
251PhosphorylationPGAICSLTCGGADIG
CCCEEECEECCCCHH		7.8821406692
259PhosphorylationCGGADIGTAMAKDER
ECCCCHHHHHHCCCC		17.3721406692
260UbiquitinationGGADIGTAMAKDERV
CCCCHHHHHHCCCCE		7.2421890473
271PhosphorylationDERVNLLSFTGSTQV
CCCEEEEEEECCCHH		24.7521712546
273PhosphorylationRVNLLSFTGSTQVGK
CEEEEEEECCCHHHH		27.1821712546
275PhosphorylationNLLSFTGSTQVGKQV
EEEEEECCCHHHHHH		16.7721712546
285SulfoxidationVGKQVGLMVQERFGR
HHHHHHHHHHHHHHC		2.1130846556
317UbiquitinationDLSLVVPSALFAAVG
CHHHHCHHHHHHHHC		26.4521890473
324UbiquitinationSALFAAVGTAGQRCT
HHHHHHHCCCHHHCH		12.7229967540
336UbiquitinationRCTTARRLFIHESIH
HCHHHHHHHHCHHHH		3.8421890473
345UbiquitinationIHESIHDEVVNRLKK
HCHHHHHHHHHHHHH		33.9121890473
352MalonylationEVVNRLKKAYAQIRV
HHHHHHHHHHHCCCC		51.7426320211
352UbiquitinationEVVNRLKKAYAQIRV
HHHHHHHHHHHCCCC		51.7429967540
354PhosphorylationVNRLKKAYAQIRVGN
HHHHHHHHHCCCCCC		14.1229496907
361UbiquitinationYAQIRVGNPWDPNVL
HHCCCCCCCCCCCCC		31.4732015554
362UbiquitinationAQIRVGNPWDPNVLY
HCCCCCCCCCCCCCC		30.8029967540
375UbiquitinationLYGPLHTKQAVSMFL
CCCCCCHHHHHHHHH		26.0529967540
379PhosphorylationLHTKQAVSMFLGAVE
CCHHHHHHHHHHHHH		13.5621406692
388UbiquitinationFLGAVEEAKKEGGTV
HHHHHHHHHHCCCEE		18.0821890473
389UbiquitinationLGAVEEAKKEGGTVV
HHHHHHHHHCCCEEE		55.4232015554
3892-HydroxyisobutyrylationLGAVEEAKKEGGTVV
HHHHHHHHHCCCEEE		55.42-
389AcetylationLGAVEEAKKEGGTVV
HHHHHHHHHCCCEEE		55.426570007
389SuccinylationLGAVEEAKKEGGTVV
HHHHHHHHHCCCEEE		55.4223954790
390UbiquitinationGAVEEAKKEGGTVVY
HHHHHHHHCCCEEEE		69.5129967540
3902-HydroxyisobutyrylationGAVEEAKKEGGTVVY
HHHHHHHHCCCEEEE		69.51-
393UbiquitinationEEAKKEGGTVVYGGK
HHHHHCCCEEEECCE		19.2121890473
402UbiquitinationVVYGGKVMDRPGNYV
EEECCEECCCCCCCC		4.0521890473
411UbiquitinationRPGNYVEPTIVTGLG
CCCCCCCCEEEECCC		19.8529967540
415UbiquitinationYVEPTIVTGLGHDAS
CCCCEEEECCCCCCH		23.8821890473
424UbiquitinationLGHDASIAHTETFAP
CCCCCHHHCCCCCCC		10.8921890473
436UbiquitinationFAPILYVFKFKNEEE
CCCEEEEEEECCHHH		4.9329967540
439AcetylationILYVFKFKNEEEVFA
EEEEEEECCHHHEEE		65.1320167786
439UbiquitinationILYVFKFKNEEEVFA
EEEEEEECCHHHEEE		65.1329967540
452UbiquitinationFAWNNEVKQGLSSSI
EEEEHHHHHCCCCCC		32.2522817900
457PhosphorylationEVKQGLSSSIFTKDL
HHHHCCCCCCCHHHH		32.2823403867
458PhosphorylationVKQGLSSSIFTKDLG
HHHCCCCCCCHHHHH		20.5323403867
462AcetylationLSSSIFTKDLGRIFR
CCCCCCHHHHHHHHH		39.96-
464UbiquitinationSSIFTKDLGRIFRWL
CCCCHHHHHHHHHHH		5.4621890473
472UbiquitinationGRIFRWLGPKGSDCG
HHHHHHHCCCCCCCE		18.2129967540
473UbiquitinationRIFRWLGPKGSDCGI
HHHHHHCCCCCCCEE		35.3521890473
478GlutathionylationLGPKGSDCGIVNVNI
HCCCCCCCEEEEEEC		4.2522555962
491UbiquitinationNIPTSGAEIGGAFGG
ECCCCCCCCCCCCCC		45.7721890473
500AcetylationGGAFGGEKHTGGGRE
CCCCCCCCCCCCCCC		50.1426051181
500UbiquitinationGGAFGGEKHTGGGRE
CCCCCCCCCCCCCCC		50.1421890473
500UbiquitinationGGAFGGEKHTGGGRE
CCCCCCCCCCCCCCC		50.1421890473
509UbiquitinationTGGGRESGSDAWKQY
CCCCCCCCHHHHHHH		25.4521890473
516PhosphorylationGSDAWKQYMRRSTCT
CHHHHHHHHHHCCCE		6.7228634298
520PhosphorylationWKQYMRRSTCTINYS
HHHHHHHCCCEEEEC		19.9228634298
521PhosphorylationKQYMRRSTCTINYSK
HHHHHHCCCEEEECC		16.3228634298
523PhosphorylationYMRRSTCTINYSKDL
HHHHCCCEEEECCCC		16.6125944883
526PhosphorylationRSTCTINYSKDLPLA
HCCCEEEECCCCCCC		17.1628152594
527PhosphorylationSTCTINYSKDLPLAQ
CCCEEEECCCCCCCC		18.4028152594
528UbiquitinationTCTINYSKDLPLAQG
CCEEEECCCCCCCCC		53.5821890473
528AcetylationTCTINYSKDLPLAQG
CCEEEECCCCCCCCC		53.5823954790
528MalonylationTCTINYSKDLPLAQG
CCEEEECCCCCCCCC		53.5826320211
537UbiquitinationLPLAQGIKFQ-----
CCCCCCCCCC-----		44.5321890473
537SuccinylationLPLAQGIKFQ-----
CCCCCCCCCC-----		44.53-
537SuccinylationLPLAQGIKFQ-----
CCCCCCCCCC-----		44.53-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AL7A1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AL7A1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AL7A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
EPS8_HUMANEPS8physical
21988832
ASNS_HUMANASNSphysical
22863883
CAN2_HUMANCAPN2physical
22863883
IF5_HUMANEIF5physical
22863883
AGAL_HUMANGLAphysical
22863883
PDIA4_HUMANPDIA4physical
22863883
PP1A_HUMANPPP1CAphysical
22863883
RISC_HUMANSCPEP1physical
22863883
1433E_HUMANYWHAEphysical
22863883
1433G_HUMANYWHAGphysical
22863883
1433F_HUMANYWHAHphysical
22863883
GABT_HUMANABATphysical
26344197
CATA_HUMANCATphysical
26344197
CPT2_HUMANCPT2physical
26344197
FAH2A_HUMANFAHD2Aphysical
26344197
AATC_HUMANGOT1physical
26344197
HIBCH_HUMANHIBCHphysical
26344197
PRDX5_HUMANPRDX5physical
26344197
DHSO_HUMANSORDphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
266100Pyridoxine-dependent epilepsy (PDE)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AL7A1_HUMAN

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Related Literatures of Post-Translational Modification

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