IP3KC_HUMAN - dbPTM
IP3KC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IP3KC_HUMAN
UniProt AC Q96DU7
Protein Name Inositol-trisphosphate 3-kinase C
Gene Name ITPKC
Organism Homo sapiens (Human).
Sequence Length 683
Subcellular Localization Nucleus . Cytoplasm . Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
Protein Description Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate..
Protein Sequence MRRCPCRGSLNEAEAGALPAAARMGLEAPRGGRRRQPGQQRPGPGAGAPAGRPEGGGPWARTEGSSLHSEPERAGLGPAPGTESPQAEFWTDGQTEPAAAGLGVETERPKQKTEPDRSSLRTHLEWSWSELETTCLWTETGTDGLWTDPHRSDLQFQPEEASPWTQPGVHGPWTELETHGSQTQPERVKSWADNLWTHQNSSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQDIEGPWTEPYTDGSQKKQDTEAARKQPGTGGFQIQQDTDGSWTQPSTDGSQTAPGTDCLLGEPEDGPLEEPEPGELLTHLYSHLKCSPLCPVPRLIITPETPEPEAQPVGPPSRVEGGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMICLLQGLAQS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Methylation-MRRCPCRGSLNEAE
-CCCCCCCCCCCHHH		23.91115480695
9PhosphorylationRRCPCRGSLNEAEAG
CCCCCCCCCCHHHHC		14.5226657352
30MethylationRMGLEAPRGGRRRQP
HHCCCCCCCCCCCCC		68.21115480687
65PhosphorylationPWARTEGSSLHSEPE
CCCCCCCCCCCCCHH		24.4027251275
66PhosphorylationWARTEGSSLHSEPER
CCCCCCCCCCCCHHH		40.7427251275
82PhosphorylationGLGPAPGTESPQAEF
CCCCCCCCCCCCCHH		32.0327251275
84PhosphorylationGPAPGTESPQAEFWT
CCCCCCCCCCCHHCC		23.3429496963
91PhosphorylationSPQAEFWTDGQTEPA
CCCCHHCCCCCCCCC		35.2627251275
95PhosphorylationEFWTDGQTEPAAAGL
HHCCCCCCCCCCCCC		49.8427251275
127PhosphorylationLRTHLEWSWSELETT
HHHHHEECHHHCEEE		16.0224275569
162PhosphorylationQFQPEEASPWTQPGV
CCCCCCCCCCCCCCC		25.01-
190PhosphorylationTQPERVKSWADNLWT
CCHHHHHHHHHHCCC		25.3329449344
224UbiquitinationPSADGSWKELYTDGS
CCCCCCCEEEECCCC		39.27-
227PhosphorylationDGSWKELYTDGSRTQ
CCCCEEEECCCCCCC		12.1323663014
228PhosphorylationGSWKELYTDGSRTQQ
CCCEEEECCCCCCCC		46.6523663014
231PhosphorylationKELYTDGSRTQQDIE
EEEECCCCCCCCCCC		34.6623663014
233PhosphorylationLYTDGSRTQQDIEGP
EECCCCCCCCCCCCC		32.0723663014
242PhosphorylationQDIEGPWTEPYTDGS
CCCCCCCCCCCCCCC		30.1623663014
245PhosphorylationEGPWTEPYTDGSQKK
CCCCCCCCCCCCHHH		15.9523663014
246PhosphorylationGPWTEPYTDGSQKKQ
CCCCCCCCCCCHHHC		44.6023663014
249PhosphorylationTEPYTDGSQKKQDTE
CCCCCCCCHHHCCHH		41.4523663014
322PhosphorylationLYSHLKCSPLCPVPR
HHHHCCCCCCCCCCE		21.2225159151
333PhosphorylationPVPRLIITPETPEPE
CCCEEEECCCCCCCC		14.2129255136
336PhosphorylationRLIITPETPEPEAQP
EEEECCCCCCCCCCC		33.8729255136
348PhosphorylationAQPVGPPSRVEGGSG
CCCCCCCCCCCCCCC		52.6825850435
361PhosphorylationSGGFSSASSFDESED
CCCCCCCCCCCCCCC		33.2228348404
362PhosphorylationGGFSSASSFDESEDD
CCCCCCCCCCCCCCC		36.1128348404
366PhosphorylationSASSFDESEDDVVAG
CCCCCCCCCCCCCCC		48.4428348404
378PhosphorylationVAGGGGASDPEDRSG
CCCCCCCCCCCCCCC		57.9027251275
398PhosphorylationKLKTVLKYSPFVVSF
HHHHHHHHCCEEEEE		19.8828555341
399PhosphorylationLKTVLKYSPFVVSFR
HHHHHHHCCEEEEEE		15.4128555341
404PhosphorylationKYSPFVVSFRKHYPW
HHCCEEEEEECCCCE		17.6528857561
456PhosphorylationLRPFVPAYYGMVLQD
CCCCCCHHHEEEECC		8.42-
457PhosphorylationRPFVPAYYGMVLQDG
CCCCCHHHEEEECCC		10.80-
499UbiquitinationYLEEELVKARERPRP
HHHHHHHHHHCCCCC		55.11-
563PhosphorylationGIKKADGTCNTNFKK
EEECCCCCCCCCHHH		11.7923312004
566PhosphorylationKADGTCNTNFKKTQA
CCCCCCCCCHHHHHH		44.1523312004
569UbiquitinationGTCNTNFKKTQALEQ
CCCCCCHHHHHHHHH		57.91-
579UbiquitinationQALEQVTKVLEDFVD
HHHHHHHHHHHHHCC		46.06-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IP3KC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IP3KC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IP3KC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PP2BC_HUMANPPP3CCphysical
21988832
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IP3KC_HUMAN

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Related Literatures of Post-Translational Modification

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