| UniProt ID | FIGN_HUMAN | |
|---|---|---|
| UniProt AC | Q5HY92 | |
| Protein Name | Fidgetin | |
| Gene Name | FIGN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 759 | |
| Subcellular Localization | Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase. | |
| Protein Description | ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.. | |
| Protein Sequence | MISSTSVYGLKMQWTPEHAQWPEQHFDITSTTRSPAHKVEAYRGHLQRTYQYAWANDDISALTASNLLKKYAEKYSGILEGPVDRPVLSNYSDTPSGLVNGRKNESEPWQPSLNSEAVYPMNCVPDVITASKAGVSSALPPADVSASIGSSPGVASNLTEPSYSSSTCGSHTVPSLHAGLPSQEYAPGYNGSYLHSTYSSQPAPALPSPHPSPLHSSGLLQPPPPPPPPPALVPGYNGTSNLSSYSYPSASYPPQTAVGSGYSPGGAPPPPSAYLPSGIPAPTPLPPTTVPGYTYQGHGLTPIAPSALTNSSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRSTQSPMYRMPDNSISNTNRGNGFDRSAETSSLAFKPTKQLMSSEQQRKFSSQSSRALTPPSYSTAKNSLGSRSSESFGKYTSPVMSEHGDEHRQLLSHPMQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTNEIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLLSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVVGPLHAMPATDLSAIMPSQLRPVTYQDFENAFCKIQPSISQKELDMYVEWNKMFGCSQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MISSTSVYGL -----CCCCCEEECC | 26.68 | 28060719 | |
| 4 | Phosphorylation | ----MISSTSVYGLK ----CCCCCEEECCC | 17.49 | 28060719 | |
| 5 | Phosphorylation | ---MISSTSVYGLKM ---CCCCCEEECCCC | 18.54 | 28060719 | |
| 6 | Phosphorylation | --MISSTSVYGLKMQ --CCCCCEEECCCCC | 18.45 | 28060719 | |
| 43 | Methylation | AHKVEAYRGHLQRTY HHHHHHHHHHHHHHH | 32.86 | - | |
| 332 | Phosphorylation | GQGDMDSSYGNYSYG CCCCCCCCCCCCCCC | 32.56 | - | |
| 333 | Phosphorylation | QGDMDSSYGNYSYGQ CCCCCCCCCCCCCCC | 17.22 | - | |
| 337 | Phosphorylation | DSSYGNYSYGQQRST CCCCCCCCCCCCCCC | 27.13 | - | |
| 338 | Phosphorylation | SSYGNYSYGQQRSTQ CCCCCCCCCCCCCCC | 14.48 | - | |
| 343 | Phosphorylation | YSYGQQRSTQSPMYR CCCCCCCCCCCCCCC | 26.85 | 24043423 | |
| 344 | Phosphorylation | SYGQQRSTQSPMYRM CCCCCCCCCCCCCCC | 34.94 | 24043423 | |
| 346 | Phosphorylation | GQQRSTQSPMYRMPD CCCCCCCCCCCCCCC | 16.24 | 16674116 | |
| 349 | Phosphorylation | RSTQSPMYRMPDNSI CCCCCCCCCCCCCCC | 13.72 | 24043423 | |
| 373 | Phosphorylation | DRSAETSSLAFKPTK CCCHHHHCCCCCCHH | 31.01 | - | |
| 377 | Acetylation | ETSSLAFKPTKQLMS HHHCCCCCCHHHHCC | 46.28 | 23236377 | |
| 400 | Phosphorylation | SQSSRALTPPSYSTA CCHHCCCCCCCHHHH | 31.97 | 21815630 | |
| 410 | Phosphorylation | SYSTAKNSLGSRSSE CHHHHHHCCCCCCCC | 33.14 | - | |
| 413 | Phosphorylation | TAKNSLGSRSSESFG HHHHCCCCCCCCCCC | 33.99 | - | |
| 423 | Phosphorylation | SESFGKYTSPVMSEH CCCCCCCCCCCCCCC | 30.00 | - | |
| 424 | Phosphorylation | ESFGKYTSPVMSEHG CCCCCCCCCCCCCCC | 16.65 | 28555341 | |
| 521 | Phosphorylation | GLTALPRSILLFGPR CCCCCCCEEEEECCC | 18.69 | - | |
| 532 | Ubiquitination | FGPRGTGKTLLGRCI ECCCCCCHHHHHHHH | 35.52 | - | |
| 607 | Phosphorylation | SPVSRMRTEFLMQLD CHHHHHHHHHHHHHH | 23.03 | 26503514 | |
| 615 | Phosphorylation | EFLMQLDTVLTSAED HHHHHHHHHCCCCCC | 26.47 | 26503514 | |
| 618 | Phosphorylation | MQLDTVLTSAEDQIV HHHHHHCCCCCCEEE | 22.89 | 26503514 | |
| 639 | Phosphorylation | KPEEIDESLRRYFMK CHHHHCHHHHHHHHH | 24.35 | 30108239 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FIGN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FIGN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FIGN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FIGN_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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