PHLP2_HUMAN - dbPTM
PHLP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHLP2_HUMAN
UniProt AC Q6ZVD8
Protein Name PH domain leucine-rich repeat-containing protein phosphatase 2
Gene Name PHLPP2
Organism Homo sapiens (Human).
Sequence Length 1323
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein. Nucleus. In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
Protein Description Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. [PubMed: 20513427 Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation]
Protein Sequence MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPVRIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSSNQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARGSCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEVPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFDTAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationNRRSRFGSRERDWLR
CCCCCCCCHHHHHHH		28.4024719451
52PhosphorylationTTTTTSSSSSSSSSS
EEEECCCCCCCCCCC		33.72-
53PhosphorylationTTTTSSSSSSSSSSS
EEECCCCCCCCCCCC		35.87-
54PhosphorylationTTTSSSSSSSSSSSD
EECCCCCCCCCCCCC		35.87-
55PhosphorylationTTSSSSSSSSSSSDL
ECCCCCCCCCCCCCE		35.87-
141UbiquitinationMIRFYGEKPCHMDRL
EEEEECCCCCCHHHH		48.89-
302UbiquitinationLYKFSQLKGLNLSHN
HHHHHHCCCCCCCCC		54.4329967540
481PhosphorylationELTLSGFSLRTLYAS
HHHHCCCCHHHHHHC		22.0724719451
547PhosphorylationVPVRILSSLSLRKLM
CCHHHHHHHCHHHHH		20.6617081983
549PhosphorylationVRILSSLSLRKLMLG
HHHHHHHCHHHHHCC		28.2417081983
591PhosphorylationRLPDTLFSKALNLRY
CCCHHHHHHHHCHHH		21.8224719451
592UbiquitinationLPDTLFSKALNLRYL
CCHHHHHHHHCHHHH		49.94-
612UbiquitinationSLESLPSACTGEESL
CHHCCCCCCCCHHHH		7.9229967540
663UbiquitinationLQTFPASKLNKLEQL
CCCCCHHHCHHHHHH		59.1829967540
666UbiquitinationFPASKLNKLEQLEEL
CCHHHCHHHHHHHHC		64.9329967540
679UbiquitinationELNLSGNKLKTIPTT
HCCCCCCCCCCCCHH		55.6929967540
691UbiquitinationPTTIANCKRLHTLVA
CHHHHHHHHHHHHHH		58.77-
1066MethylationTTIKDAPKPATPSSS
CCCCCCCCCCCCCCC		49.34-
1119PhosphorylationPRPERRCSLHPTPTS
CCCCCCCCCCCCCCC		28.0928152594
1123PhosphorylationRRCSLHPTPTSGLFQ
CCCCCCCCCCCCCCC		28.5728152594
1125PhosphorylationCSLHPTPTSGLFQRQ
CCCCCCCCCCCCCCC		37.5927080861
1126PhosphorylationSLHPTPTSGLFQRQP
CCCCCCCCCCCCCCC		34.4027080861
1143PhosphorylationATFSSNQSDNGLDSD
CEECCCCCCCCCCCC		36.9832645325
1149PhosphorylationQSDNGLDSDDDQPVE
CCCCCCCCCCCCCCE		48.24-
1182PhosphorylationRGRDLENSPPLIESS
CCCCCCCCCCCCCCC		20.6528985074
1188PhosphorylationNSPPLIESSPTLCSE
CCCCCCCCCCCCCCC		34.3227050516
1189PhosphorylationSPPLIESSPTLCSEE
CCCCCCCCCCCCCCC		14.7629978859
1191PhosphorylationPLIESSPTLCSEEHA
CCCCCCCCCCCCCHH		42.2029978859
1194PhosphorylationESSPTLCSEEHARGS
CCCCCCCCCCHHCCC		49.4829978859
1210PhosphorylationFGIRRQNSVNSGMLL
CCCCCCCCCCCCCEE		17.8422617229
1213PhosphorylationRRQNSVNSGMLLPMS
CCCCCCCCCCEECCC		24.3528450419
1220PhosphorylationSGMLLPMSKDRMELQ
CCCEECCCCCCHHHC		29.4829083192
1229PhosphorylationDRMELQKSPSTSCLY
CCHHHCCCCCCCHHC		15.8925159151
1231PhosphorylationMELQKSPSTSCLYGK
HHHCCCCCCCHHCCC		39.7925849741
1232PhosphorylationELQKSPSTSCLYGKK
HHCCCCCCCHHCCCC		27.1830576142
1233PhosphorylationLQKSPSTSCLYGKKL
HCCCCCCCHHCCCCC		13.3828985074
1236PhosphorylationSPSTSCLYGKKLSNG
CCCCCHHCCCCCCCC		31.0929083192
1241PhosphorylationCLYGKKLSNGSIVPL
HHCCCCCCCCCEEEH		48.2829496963
1244PhosphorylationGKKLSNGSIVPLEDS
CCCCCCCCEEEHHHH		25.3529496963
1251PhosphorylationSIVPLEDSLNLIEVA
CEEEHHHHHHHHHHH		15.1328450419
1259PhosphorylationLNLIEVATEVPKRKT
HHHHHHHHCCCCCCC		42.5723090842
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHLP2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHLP2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHLP2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RADI_HUMANRDXphysical
19615732
UBP1_HUMANUSP1physical
19615732
EZRI_HUMANEZRphysical
19615732
NHRF2_HUMANSLC9A3R2physical
19615732
NHRF1_HUMANSLC9A3R1physical
19615732
VAT1_HUMANVAT1physical
19615732
WDR48_HUMANWDR48physical
19615732
UBP46_HUMANUSP46physical
19615732
SNX27_HUMANSNX27physical
19615732
WDR20_HUMANWDR20physical
19615732
UBP12_HUMANUSP12physical
19615732
UBP12_HUMANUSP12physical
25216524
WDR48_HUMANWDR48physical
25216524
WDR20_HUMANWDR20physical
25216524
NHRF1_HUMANSLC9A3R1physical
21804599
DMWD_HUMANDMWDphysical
27880917
NHRF1_HUMANSLC9A3R1physical
27880917
NHRF2_HUMANSLC9A3R2physical
27880917
SNX27_HUMANSNX27physical
27880917
SGT1_HUMANSUGT1physical
27880917
UBP1_HUMANUSP1physical
27880917
UBP12_HUMANUSP12physical
27880917
UBP46_HUMANUSP46physical
27880917
VAT1_HUMANVAT1physical
27880917
WDR20_HUMANWDR20physical
27880917
WDR48_HUMANWDR48physical
27880917
CUL3_HUMANCUL3physical
28859855
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHLP2_HUMAN

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Related Literatures of Post-Translational Modification

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