UBP12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP12_HUMAN
• UniProt AC: O75317
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 12
• Gene Name: USP12
• Organism: Homo sapiens (Human).
• Sequence Length: 370
• Protein Description: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. [PubMed: 19075014]
• Protein Sequence: MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	Ubiquitination	FHSIATQKKKVGVIP HHHHHHCCCCCCCCC	50.65	33845483
264	Phosphorylation	LHLKRFKYMDQLHRY HHHHHHHCHHHHHHH	11.83	-
271	Phosphorylation	YMDQLHRYTKLSYRV CHHHHHHHHCCCEEE	9.47	-
273	Ubiquitination	DQLHRYTKLSYRVVF HHHHHHHCCCEEEEE	26.88	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHX8_HUMAN	DHX8	physical	19615732
DMWD_HUMAN	DMWD	physical	19615732
MMP2_HUMAN	MMP2	physical	19615732
PAIP1_HUMAN	PAIP1	physical	19615732
R51A1_HUMAN	RAD51AP1	physical	19615732
SNUT2_HUMAN	USP39	physical	19615732
PHLP2_HUMAN	PHLPP2	physical	19615732
PHLP1_HUMAN	PHLPP1	physical	19615732
NU160_HUMAN	NUP160	physical	19615732
CAB45_HUMAN	SDF4	physical	19615732
UCHL5_HUMAN	UCHL5	physical	19615732
WDR48_HUMAN	WDR48	physical	19615732
WDR20_HUMAN	WDR20	physical	19615732
H2A2C_HUMAN	HIST2H2AC	physical	21183687
WDR48_HUMAN	WDR48	physical	21183687
DMWD_HUMAN	DMWD	physical	21183687
WDR20_HUMAN	WDR20	physical	21183687
WDR26_HUMAN	WDR26	physical	21183687
MEP50_HUMAN	WDR77	physical	21183687
H2B2E_HUMAN	HIST2H2BE	physical	21183687
ITCH_HUMAN	ITCH	physical	22778262
A4_HUMAN	APP	physical	21832049
WDR48_HUMAN	WDR48	physical	19075014
NOTC1_HUMAN	NOTCH1	physical	22778262
CBLB_HUMAN	CBLB	physical	26811477
ITCH_HUMAN	ITCH	physical	26811477
WDR48_HUMAN	WDR48	physical	26811477
ZAP70_HUMAN	ZAP70	physical	26811477
WDR20_HUMAN	WDR20	physical	26811477
UBP46_HUMAN	USP46	physical	26811477
LAT_HUMAN	LAT	physical	26811477
GRB2_HUMAN	GRB2	physical	26811477
TRAT1_HUMAN	TRAT1	physical	26811477
WDR20_HUMAN	WDR20	physical	26462181
WDR48_HUMAN	WDR48	physical	26462181
WDR48_HUMAN	WDR48	physical	27650958
WDR48_HUMAN	WDR48	physical	27373336
WDR20_HUMAN	WDR20	physical	27373336
PHLP1_HUMAN	PHLPP1	physical	24145035

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.