STAR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAR3_HUMAN
• UniProt AC: Q14849
• Protein Name: StAR-related lipid transfer protein 3 {ECO:0000305}
• Gene Name: STARD3 {ECO:0000312|HGNC:HGNC:17579}
• Organism: Homo sapiens (Human).
• Sequence Length: 445
• Subcellular Localization: Late endosome membrane ; Multi-pass membrane protein . Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA and VAPB (PubMed:24105263).
• Protein Description: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. [PubMed: 11053434]
• Protein Sequence: MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQSLAATMFEFAFHLRQRISELGARA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LTRDLERSLPAVASL HHHHHHHHHHHHHHC	29.36	27732954
21	Phosphorylation	RSLPAVASLGSSLSH HHHHHHHHCCCCCCC	27.02	28857561
24	Phosphorylation	PAVASLGSSLSHSQS HHHHHCCCCCCCCCC	33.14	28857561
25	Phosphorylation	AVASLGSSLSHSQSL HHHHCCCCCCCCCCH	31.90	28857561
27	Phosphorylation	ASLGSSLSHSQSLSS HHCCCCCCCCCCHHH	24.04	27732954
29	Phosphorylation	LGSSLSHSQSLSSHL CCCCCCCCCCHHHHC	20.35	30576142
31	Phosphorylation	SSLSHSQSLSSHLLP CCCCCCCCHHHHCCC	32.98	30576142
33	Phosphorylation	LSHSQSLSSHLLPPP CCCCCCHHHHCCCCH	22.43	27732954
34	Phosphorylation	SHSQSLSSHLLPPPE CCCCCHHHHCCCCHH	24.36	27732954
47	Phosphorylation	PEKRRAISDVRRTFC HHHHCHHHHHHHHHH	29.12	25106551
146	Phosphorylation	VILSELLSKGAFGYL HHHHHHHHCCCCHHH	41.49	-
166 (in isoform 3)	Phosphorylation	-	21.24	-
199	Phosphorylation	ARGPLLFSGALSEGQ HCCCEEEECCCCCCC	24.11	28102081
203	Phosphorylation	LLFSGALSEGQFYSP EEEECCCCCCCCCCC	38.86	28102081
208	Phosphorylation	ALSEGQFYSPPESFA CCCCCCCCCCCHHHC	16.63	28102081
209	Phosphorylation	LSEGQFYSPPESFAG CCCCCCCCCCHHHCC	34.95	20363803
213	Phosphorylation	QFYSPPESFAGSDNE CCCCCCHHHCCCCCC	26.60	28102081
217	Phosphorylation	PPESFAGSDNESDEE CCHHHCCCCCCCHHH	33.56	20363803
221	Phosphorylation	FAGSDNESDEEVAGK HCCCCCCCHHHHCCC	57.48	20363803
225	Ubiquitination	DNESDEEVAGKKSFS CCCCHHHHCCCCCCC	8.83	29967540
230	Phosphorylation	EEVAGKKSFSAQERE HHHCCCCCCCHHHHH	28.11	28102081
232	Phosphorylation	VAGKKSFSAQEREYI HCCCCCCCHHHHHHH	35.81	28102081
242	Ubiquitination	EREYIRQGKEATAVV HHHHHHCCHHHHHHH	21.66	29967540
243	Ubiquitination	REYIRQGKEATAVVD HHHHHCCHHHHHHHH	35.52	29967540
245	Ubiquitination	YIRQGKEATAVVDQI HHHCCHHHHHHHHHH	12.35	33845483
260	Ubiquitination	LAQEENWKFEKNNEY HHHHHCCCCCCCCCC	56.05	29967540
263	Ubiquitination	EENWKFEKNNEYGDT HHCCCCCCCCCCCCE	69.11	33845483
281	Ubiquitination	IEVPFHGKTFILKTF EEEECCCEEEEEEEE	31.52	29967540
307	Sulfoxidation	VILQPERMVLWNKTV HHCCCCHHHHCCCCH	2.50	29593096
427	Sulfoxidation	HQSLAATMFEFAFHL HHHHHHHHHHHHHHH	2.31	29593096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOPC_HUMAN	GOPC	physical	25416956
CBARP_HUMAN	C19orf26	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.