CDS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDS1_HUMAN
• UniProt AC: Q92903
• Protein Name: Phosphatidate cytidylyltransferase 1
• Gene Name: CDS1
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic aspect of the endoplasmic reticulum..
• Protein Description: Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells..
• Protein Sequence: MLELRHRGSCPGPREAVSPPHREGEAAGGDHETESTSDKETDIDDRYGDLDSRTDSDIPEIPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFLIIYMGSFMLMLLVLGIQVKCFHEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVVFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQTYSLPPFLKAVLRQERVSLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYKTLKTHLIEKGILQPTLKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Methylation	-MLELRHRGSCPGPR -CCCCCCCCCCCCCC	32.08	-
9	Phosphorylation	LELRHRGSCPGPREA CCCCCCCCCCCCCCC	19.66	29691806
18	Phosphorylation	PGPREAVSPPHREGE CCCCCCCCCCCCCCC	39.50	30624053
33	Phosphorylation	AAGGDHETESTSDKE CCCCCCCCCCCCCCC	31.64	30278072
35	Phosphorylation	GGDHETESTSDKETD CCCCCCCCCCCCCCC	40.40	30278072
36	Phosphorylation	GDHETESTSDKETDI CCCCCCCCCCCCCCC	34.41	30278072
37	Phosphorylation	DHETESTSDKETDID CCCCCCCCCCCCCCC	56.83	30278072
41	Phosphorylation	ESTSDKETDIDDRYG CCCCCCCCCCCCCCC	43.95	23927012
47	Phosphorylation	ETDIDDRYGDLDSRT CCCCCCCCCCCCCCC	23.22	25002506
54	Phosphorylation	YGDLDSRTDSDIPEI CCCCCCCCCCCCCCC	43.75	30242111
56	Phosphorylation	DLDSRTDSDIPEIPP CCCCCCCCCCCCCCC	36.51	24719451
64	Phosphorylation	DIPEIPPSSDRTPEI CCCCCCCCCCCCHHH	39.24	26471730
65	Phosphorylation	IPEIPPSSDRTPEIL CCCCCCCCCCCHHHH	36.56	26471730
68	Phosphorylation	IPPSSDRTPEILKKA CCCCCCCCHHHHHHH	30.20	24076635
80	Phosphorylation	KKALSGLSSRWKNWW HHHHCCCCHHHHHHH	22.76	23911959
81	Phosphorylation	KALSGLSSRWKNWWI HHHCCCCHHHHHHHH	47.40	23911959
201	Phosphorylation	GFCMFVLSLVKKHYR HHHHHHHHHHHHHHH	26.30	24719451
266	Phosphorylation	FGFFFGRTPLIKLSP HHHHHCCCCCEECCC	23.87	24719451
270	Ubiquitination	FGRTPLIKLSPKKTW HCCCCCEECCCCCCC	51.07	21890473
276	Phosphorylation	IKLSPKKTWEGFIGG EECCCCCCCCCCHHH	34.57	-
286	Phosphorylation	GFIGGFFSTVVFGFI CCHHHHHHHHHHHHH	20.31	-
384	Ubiquitination	FKRAFKIKDFANTIP HHHHEEHHHHHHCCC	47.59	21890473
442	Phosphorylation	PEQQLNIYKTLKTHL HHHHHHHHHHHHHHH	9.24	24260401
447	Phosphorylation	NIYKTLKTHLIEKGI HHHHHHHHHHHHCCC	25.65	-
458	Phosphorylation	EKGILQPTLKV---- HCCCCCCCCCC----	26.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
68	T	Phosphorylation	Kinase	ATM	Q13315	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPIP3_HUMAN	CDC25C	physical	10681541
SNX27_HUMAN	SNX27	physical	28514442
REEP6_HUMAN	REEP6	physical	28514442
TSN6_HUMAN	TSPAN6	physical	28514442
ITB1_HUMAN	ITGB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.