TSN6_HUMAN - dbPTM
TSN6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSN6_HUMAN
UniProt AC O43657
Protein Name Tetraspanin-6
Gene Name TSPAN6
Organism Homo sapiens (Human).
Sequence Length 245
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description
Protein Sequence MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIATGTVIILLGTFGCFATCRASAWMLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
49PhosphorylationGKVSLENYFSLLNEK
CHHCHHHHHHHHCHH		5.7929759185
51PhosphorylationVSLENYFSLLNEKAT
HCHHHHHHHHCHHCC		22.9129759185
123"N6,N6-dimethyllysine"HEIKNSFKNNYEKAL
HHHHHHHHCCHHHHH		44.07-
123UbiquitinationHEIKNSFKNNYEKAL
HHHHHHHHCCHHHHH		44.07-
123MethylationHEIKNSFKNNYEKAL
HHHHHHHHCCHHHHH		44.0723644510
1282-HydroxyisobutyrylationSFKNNYEKALKQYNS
HHHCCHHHHHHHHCC		48.97-
128UbiquitinationSFKNNYEKALKQYNS
HHHCCHHHHHHHHCC		48.9721906983
131UbiquitinationNNYEKALKQYNSTGD
CCHHHHHHHHCCCCC		56.4421906983
134N-linked_GlycosylationEKALKQYNSTGDYRS
HHHHHHHCCCCCHHH		30.51UniProtKB CARBOHYD
146UbiquitinationYRSHAVDKIQNTLHC
HHHHHHHHHHHHHEC		39.32-
160MethylationCCGVTDYRDWTDTNY
CCCCCCCCCCCCCCC		35.48115919069
163PhosphorylationVTDYRDWTDTNYYSE
CCCCCCCCCCCCCCC		36.9229083192
165PhosphorylationDYRDWTDTNYYSEKG
CCCCCCCCCCCCCCC		20.1129083192
167PhosphorylationRDWTDTNYYSEKGFP
CCCCCCCCCCCCCCC		15.5129083192
168PhosphorylationDWTDTNYYSEKGFPK
CCCCCCCCCCCCCCH		16.6629083192
169PhosphorylationWTDTNYYSEKGFPKS
CCCCCCCCCCCCCHH		23.6029083192
171UbiquitinationDTNYYSEKGFPKSCC
CCCCCCCCCCCHHHC		60.972190698
177S-palmitoylationEKGFPKSCCKLEDCT
CCCCCHHHCCCCCCC		2.7229575903
178S-palmitoylationKGFPKSCCKLEDCTP
CCCCHHHCCCCCCCC		7.9129575903
179UbiquitinationGFPKSCCKLEDCTPQ
CCCHHHCCCCCCCCC		60.27-
183S-palmitoylationSCCKLEDCTPQRDAD
HHCCCCCCCCCCCHH		4.3429575903
191UbiquitinationTPQRDADKVNNEGCF
CCCCCHHHCCCCCCE		48.89-
242PhosphorylationRAITNNQYEIV----
HHHHCCCCCCC----		15.1128152594
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSN6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSN6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSN6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CHD3_HUMANCHD3physical
16169070
LRIF1_HUMANLRIF1physical
16169070
NSG2_HUMANHMP19physical
21900206
MAVS_HUMANMAVSphysical
22908223
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSN6_HUMAN

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Related Literatures of Post-Translational Modification

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