LAT4_HUMAN - dbPTM
LAT4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAT4_HUMAN
UniProt AC Q8N370
Protein Name Large neutral amino acids transporter small subunit 4
Gene Name SLC43A2
Organism Homo sapiens (Human).
Sequence Length 569
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids..
Protein Sequence MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTEPENVTNGTVGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVDLEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQKTVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAPTLATAHRR
----CCCCHHHHHHH		21.3426074081
7Phosphorylation-MAPTLATAHRRRWW
-CCCCHHHHHHHHHH		26.5526074081
18PhosphorylationRRWWMACTAVLENLL
HHHHHHHHHHHHHHH		15.4026074081
55N-linked_GlycosylationYLCTEPENVTNGTVG
EECCCCCCCCCCCCC		57.54UniProtKB CARBOHYD
58N-linked_GlycosylationTEPENVTNGTVGGTA
CCCCCCCCCCCCCCC		39.60UniProtKB CARBOHYD
123UbiquitinationRKLRLLGSACFAVSC
HHHHHHHHHHHHHHH		23.1029967540
123PhosphorylationRKLRLLGSACFAVSC
HHHHHHHHHHHHHHH		23.1030576142
140PhosphorylationIAYGASKPNALSVLI
HHHCCCCCCHHHHHH		28.9133259812
146UbiquitinationKPNALSVLIFIALAL
CCCHHHHHHHHHHHH		2.0833845483
146UbiquitinationKPNALSVLIFIALAL
CCCHHHHHHHHHHHH		2.08-
160PhosphorylationLNGFGGMCMTFTSLT
HCCCCCHHHHHHHCC		2.3532142685
249PhosphorylationYSVKIKFSWLGFDHK
EEEEEEEEECCCCCE		19.1828857561
250UbiquitinationSVKIKFSWLGFDHKI
EEEEEEEECCCCCEE		12.0221987572
260UbiquitinationFDHKITGKQFYKQVT
CCCEECCHHHHHCHH		28.6929967540
265UbiquitinationTGKQFYKQVTTVGRR
CCHHHHHCHHCCCHH		26.81-
265UbiquitinationTGKQFYKQVTTVGRR
CCHHHHHCHHCCCHH		26.8121963094
267PhosphorylationKQFYKQVTTVGRRLS
HHHHHCHHCCCHHCC		17.1724173317
268PhosphorylationQFYKQVTTVGRRLSV
HHHHCHHCCCHHCCC		23.3123312004
274PhosphorylationTTVGRRLSVGSSMRS
HCCCHHCCCCCHHHC		23.7125159151
277PhosphorylationGRRLSVGSSMRSAKE
CHHCCCCCHHHCHHH		20.8530266825
278PhosphorylationRRLSVGSSMRSAKEQ
HHCCCCCHHHCHHHH		16.5823927012
281PhosphorylationSVGSSMRSAKEQVAL
CCCCHHHCHHHHHHH		34.7428857561
283 (in isoform 2)Ubiquitination-50.3421906983
283 (in isoform 3)Ubiquitination-50.3421906983
283 (in isoform 1)Ubiquitination-50.3421906983
283UbiquitinationGSSMRSAKEQVALQE
CCHHHCHHHHHHHHC		50.3421906983
293UbiquitinationVALQEGHKLCLSTVD
HHHHCCCCEEEEECC		52.32-
297PhosphorylationEGHKLCLSTVDLEVK
CCCCEEEEECCEEEE		25.9525159151
298PhosphorylationGHKLCLSTVDLEVKC
CCCEEEEECCEEEEC		12.7030266825
369UbiquitinationLYTSIFGVLQLLCLL
HHHHHHHHHHHHHHH		1.8321963094
396PhosphorylationLKECEDASEEPEEKD
HHHCCCCCCCCCHHC		55.6128857561
402UbiquitinationASEEPEEKDANQGEK
CCCCCCHHCCCHHHH		61.5521906983
402 (in isoform 1)Ubiquitination-61.5521906983
406UbiquitinationPEEKDANQGEKKKKK
CCHHCCCHHHHHHHH		64.2421963094
406 (in isoform 3)Ubiquitination-64.2421906983
421UbiquitinationRDRQIQKITNAMRAF
HHHHHHHHHHHHHHH		1.74-
421UbiquitinationRDRQIQKITNAMRAF
HHHHHHHHHHHHHHH		1.7421963094
441PhosphorylationLLVGFGVTCLIPNLP
HHHCCCCCCCCCCCC		11.2825332170
453PhosphorylationNLPLQILSFILHTIV
CCCHHHHHHHHHHHH		16.3325332170
458PhosphorylationILSFILHTIVRGFIH
HHHHHHHHHHHHHHH		20.0925332170
525UbiquitinationNVGLLLLSLLGFCLP
HHHHHHHHHHHHHHH		22.8621963094
558UbiquitinationEDDKLFLKINGSSNQ
HCCCEEEEECCCCCC		27.132190698
558 (in isoform 1)Ubiquitination-27.1321906983
560N-linked_GlycosylationDKLFLKINGSSNQEA
CCEEEEECCCCCCCC		42.58UniProtKB CARBOHYD
562UbiquitinationLFLKINGSSNQEAFV
EEEEECCCCCCCCCC		22.9421963094
562PhosphorylationLFLKINGSSNQEAFV
EEEEECCCCCCCCCC		22.9425627689
562 (in isoform 3)Ubiquitination-22.9421906983
563PhosphorylationFLKINGSSNQEAFV-
EEEECCCCCCCCCC-		43.8828985074
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAT4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAT4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAT4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KR103_HUMANKRTAP10-3physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAT4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274 AND SER-278, ANDMASS SPECTROMETRY.

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