ALG8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALG8_HUMAN
• UniProt AC: Q9BVK2
• Protein Name: Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
• Gene Name: ALG8
• Organism: Homo sapiens (Human).
• Sequence Length: 526
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity)..
• Protein Sequence: MAALTIATGTGNWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHSLPISQWYYEATSEWTLDYPPFFAWFEYILSHVAKYFDQEMLNVHNLNYSSSRTLLFQRFSVIFMDVLFVYAVRECCKCIDGKKVGKELTEKPKFILSVLLLWNFGLLIVDHIHFQYNGFLFGLMLLSIARLFQKRHMEGAFLFAVLLHFKHIYLYVAPAYGVYLLRSYCFTANKPDGSIRWKSFSFVRVISLGLVVFLVSALSLGPFLALNQLPQVFSRLFPFKRGLCHAYWAPNFWALYNALDKVLSVIGLKLKFLDPNNIPKASMTSGLVQQFQHTVLPSVTPLATLICTLIAILPSIFCLWFKPQGPRGFLRCLTLCALSSFMFGWHVHEKAILLAILPMSLLSVGKAGDASIFLILTTTGHYSLFPLLFTAPELPIKILLMLLFTIYSISSLKTLFRKEKPLFNWMETFYLLGLGPLEVCCEFVFPFTSWKVKYPFIPLLLTSVYCAVGITYAWFKLYVSVLIDSAIGKTKKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	LIPTYHSTDFEVHRN HCCCCCCCCHHHHHH	31.25	24719451
49	Phosphorylation	NWLAITHSLPISQWY HHHHHEECCCHHHHH	27.47	22251617
53	Phosphorylation	ITHSLPISQWYYEAT HEECCCHHHHHHHCC	16.84	22251625
61	Phosphorylation	QWYYEATSEWTLDYP HHHHHCCCCCCCCCC	37.88	22251633
138	Phosphorylation	KKVGKELTEKPKFIL CCCCHHHHCCCHHHH	42.95	29083192
216	Phosphorylation	YGVYLLRSYCFTANK HHHHHHHHHHEECCC	26.65	46162311
223	Ubiquitination	SYCFTANKPDGSIRW HHHEECCCCCCCEEC	41.86	21906983
231	Ubiquitination	PDGSIRWKSFSFVRV CCCCEECCCCCHHHH	31.60	21890473
231	Ubiquitination	PDGSIRWKSFSFVRV CCCCEECCCCCHHHH	31.60	21890473
273	Ubiquitination	FSRLFPFKRGLCHAY HHHHCCCCCCCCCCC	45.88	-
302	Ubiquitination	VLSVIGLKLKFLDPN HHHHHCCCCEECCCC	44.40	-
304	Ubiquitination	SVIGLKLKFLDPNNI HHHCCCCEECCCCCC	42.15	21890473
304	Ubiquitination	SVIGLKLKFLDPNNI HHHCCCCEECCCCCC	42.15	21890473
440	Phosphorylation	LMLLFTIYSISSLKT HHHHHHHHHHHHHHH	9.26	29496907
443	Phosphorylation	LFTIYSISSLKTLFR HHHHHHHHHHHHHHH	24.55	24719451
444	Phosphorylation	FTIYSISSLKTLFRK HHHHHHHHHHHHHHC	32.01	29496907
511	Phosphorylation	TYAWFKLYVSVLIDS HHHHHHHHHHHHHHH	7.41	46162317

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALG8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALG8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALG8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ULA1_HUMAN	NAE1	physical	21988832
KS6A5_HUMAN	RPS6KA5	physical	21988832

Drug and Disease Associations

• Kegg Disease
• H00118: Congenital disorders of glycosylation (CDG) type I
• OMIM Disease
• 608104: Congenital disorder of glycosylation 1H (CDG1H)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.