LAT3_HUMAN - dbPTM
LAT3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAT3_HUMAN
UniProt AC O75387
Protein Name Large neutral amino acids transporter small subunit 3
Gene Name SLC43A1 {ECO:0000312|EMBL:AAH01639.1}
Organism Homo sapiens (Human).
Sequence Length 559
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer..
Protein Sequence MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGTVLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQQEYAANGMGPLKVLSGSEVTA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAPTLQQAYRR
----CCCHHHHHHHH		27.8825072903
9PhosphorylationAPTLQQAYRRRWWMA
CCHHHHHHHHHHHHH		10.5825072903
46PhosphorylationILKNEGFYSSTCPAE
EEECCCCCCCCCCCC		16.75-
57N-linked_GlycosylationCPAESSTNTTQDEQR
CCCCCCCCCCHHHHH		42.97UniProtKB CARBOHYD
165PhosphorylationNMFGNLRSTLMALMI
CCCCCHHHHHHHHHH		29.1126552605
166PhosphorylationMFGNLRSTLMALMIG
CCCCHHHHHHHHHHH		17.7026552605
174PhosphorylationLMALMIGSYASSAIT
HHHHHHHHHHCCCCC		13.4526552605
175PhosphorylationMALMIGSYASSAITF
HHHHHHHHHCCCCCC		12.8026552605
177PhosphorylationLMIGSYASSAITFPG
HHHHHHHCCCCCCCC		16.4526552605
178PhosphorylationMIGSYASSAITFPGI
HHHHHHCCCCCCCCC		18.6026552605
181PhosphorylationSYASSAITFPGIKLI
HHHCCCCCCCCCHHH		24.4026552605
212N-linked_GlycosylationLACLIFLNCTLNWPI
HHHHHHHHCCCCCCH		13.13UniProtKB CARBOHYD
229N-linked_GlycosylationFPAPEEVNYTKKIKL
CCCCCCCCCCCEEEE		41.87UniProtKB CARBOHYD
235UbiquitinationVNYTKKIKLSGLALD
CCCCCEEEECCCCCC		45.54-
237PhosphorylationYTKKIKLSGLALDHK
CCCEEEECCCCCCCE		27.1025072903
244UbiquitinationSGLALDHKVTGDLFY
CCCCCCCEECCCCCC		40.95-
246PhosphorylationLALDHKVTGDLFYTH
CCCCCEECCCCCCEE		29.7621945579
251 (in isoform 2)Phosphorylation-11.8427642862
251PhosphorylationKVTGDLFYTHVTTMG
EECCCCCCEEECHHH		11.8421945579
252PhosphorylationVTGDLFYTHVTTMGQ
ECCCCCCEEECHHHH		11.5321945579
255PhosphorylationDLFYTHVTTMGQRLS
CCCCEEECHHHHHHH		11.9421945579
256PhosphorylationLFYTHVTTMGQRLSQ
CCCEEECHHHHHHHH		20.4429978859
262 (in isoform 2)Phosphorylation-31.6527642862
262PhosphorylationTTMGQRLSQKAPSLE
CHHHHHHHHCCCCCC		31.6528450419
264 (in isoform 1)Ubiquitination-59.9121906983
264 (in isoform 2)Ubiquitination-59.9121906983
264UbiquitinationMGQRLSQKAPSLEDG
HHHHHHHCCCCCCCC		59.912190698
267PhosphorylationRLSQKAPSLEDGSDA
HHHHCCCCCCCCCCC		49.619722952
272PhosphorylationAPSLEDGSDAFMSPQ
CCCCCCCCCCCCCHH		37.7828464451
277PhosphorylationDGSDAFMSPQDVRGT
CCCCCCCCHHHCCCC		16.9827251275
284PhosphorylationSPQDVRGTSENLPER
CHHHCCCCCCCCCCC		23.4627470641
285PhosphorylationPQDVRGTSENLPERS
HHHCCCCCCCCCCCC		27.5825072903
298PhosphorylationRSVPLRKSLCSPTFL
CCCCCCHHHCCHHHH		28.3326552605
301PhosphorylationPLRKSLCSPTFLWSL
CCCHHHCCHHHHHHH		32.0626552605
303PhosphorylationRKSLCSPTFLWSLLT
CHHHCCHHHHHHHHH		18.3126552605
307PhosphorylationCSPTFLWSLLTMGMT
CCHHHHHHHHHCCHH		18.6926552605
310PhosphorylationTFLWSLLTMGMTQLR
HHHHHHHHCCHHHHH		19.5726552605
314PhosphorylationSLLTMGMTQLRIIFY
HHHHCCHHHHHHHHH		20.7926552605
321PhosphorylationTQLRIIFYMAAVNKM
HHHHHHHHHHHHHHH		3.87-
382UbiquitinationYIMDWRIKDCVDAPT
HHHCCCHHHHCCCCC		36.18-
382 (in isoform 2)Ubiquitination-36.18-
404UbiquitinationARDGVATKSIRPRYC
CCCCCCCCCCCCCCH		33.86-
404 (in isoform 2)Ubiquitination-33.86-
426PhosphorylationAISAFTLTNLLLVGF
HHHHHHHHHHHHHHH		22.29-
558PhosphorylationVLSGSEVTA------
EECCCCCCC------		23.6924670416
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAT3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAT3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAT3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LAT3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAT3_HUMAN

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Related Literatures of Post-Translational Modification

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