SNX15_HUMAN - dbPTM
SNX15_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNX15_HUMAN
UniProt AC Q9NRS6
Protein Name Sorting nexin-15
Gene Name SNX15
Organism Homo sapiens (Human).
Sequence Length 342
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein
Cytoplasmic side . Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN..
Protein Sequence MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATMEVESARLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVHVLLQGVPSDPLPARQEGVKKKAAEYLKRAEEILRLHLSQLPP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MSRQAKDDFLRHY
--CCHHHHHCHHHHC		49.87-
6Ubiquitination--MSRQAKDDFLRHY
--CCHHHHHCHHHHC		49.87-
91PhosphorylationVFGRFEASVIEERRK
HHHHHHHHHHHHHHC		19.2128857561
105MethylationKGAEDLLRFTVHIPA
CCHHHHHHHEEECHH		32.27-
116PhosphorylationHIPALNNSPQLKEFF
ECHHCCCCHHHHHHH		16.9825159151
124MethylationPQLKEFFRGGEVTRP
HHHHHHHCCCCCCCC		58.49115917429
148PhosphorylationLPPPLIPTPPPDDPR
CCCCCCCCCCCCCCH		41.2430266825
157PhosphorylationPPDDPRLSQLLPAER
CCCCCHHHHHCHHHH		21.7724247654
179PhosphorylationVPVDPPPSSPAQEAL
CCCCCCCCCHHHHHH		55.5228450419
180PhosphorylationPVDPPPSSPAQEALD
CCCCCCCCHHHHHHH		29.9928464451
194PhosphorylationDLLFNCESTEEASGS
HHHHCCCCCCHHCCC		43.2328450419
195PhosphorylationLLFNCESTEEASGSP
HHHCCCCCCHHCCCC		18.6227732954
199PhosphorylationCESTEEASGSPARGP
CCCCCHHCCCCCCCC		42.9828450419
201PhosphorylationSTEEASGSPARGPLT
CCCHHCCCCCCCCCC		16.9430278072
208PhosphorylationSPARGPLTEAELALF
CCCCCCCCHHHHHHC		35.9627080861
219PhosphorylationLALFDPFSKEEGAAP
HHHCCCCCCCCCCCC		44.5427080861
227PhosphorylationKEEGAAPSPTHVAEL
CCCCCCCCCCHHHHH		37.3930266825
229PhosphorylationEGAAPSPTHVAELAT
CCCCCCCCHHHHHHC		33.0630266825
236PhosphorylationTHVAELATMEVESAR
CHHHHHHCCCHHHHC		26.8722199227
241PhosphorylationLATMEVESARLDQEP
HHCCCHHHHCCCCCC		24.7022199227
265PhosphorylationEDGEGGPTPAYLSQA
CCCCCCCCHHHHHHH		24.6728787133
268PhosphorylationEGGPTPAYLSQATEL
CCCCCHHHHHHHHHH		14.2128787133
273PhosphorylationPAYLSQATELITQAL
HHHHHHHHHHHHHHH		24.5628787133
277PhosphorylationSQATELITQALRDEK
HHHHHHHHHHHHHHH		22.0328787133
288PhosphorylationRDEKAGAYAAALQGY
HHHHCHHHHHHHCCC		8.8927642862
308PhosphorylationVLLQGVPSDPLPARQ
EEEECCCCCCCCCHH		49.8320873877
325PhosphorylationVKKKAAEYLKRAEEI
HHHHHHHHHHHHHHH		16.8828176486
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNX15_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNX15_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNX15_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS36_HUMANVPS36physical
22939629
KDM1A_HUMANKDM1Aphysical
23455924
RTN4_HUMANRTN4physical
25416956
REEP6_HUMANREEP6physical
25416956
RTN4_HUMANRTN4physical
21516116
REEP6_HUMANREEP6physical
21516116
5NTC_HUMANNT5C2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNX15_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-148, AND MASSSPECTROMETRY.

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