dbPTM

5NTC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	5NTC_HUMAN
UniProt AC	P49902
Protein Name	Cytosolic purine 5'-nucleotidase
Gene Name	NT5C2
Organism	Homo sapiens (Human).
Sequence Length	561
Subcellular Localization	Cytoplasm.
Protein Description	May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides..
Protein Sequence	MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEEE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTSWSDRL ------CCCCHHHHH	31.02	25159151
3	Phosphorylation	-----MSTSWSDRLQ -----CCCCHHHHHH	32.68	25159151
4	Phosphorylation	----MSTSWSDRLQN ----CCCCHHHHHHH	19.78	25159151
6	Phosphorylation	--MSTSWSDRLQNAA --CCCCHHHHHHHHH	16.78	29514088
15	Sulfoxidation	RLQNAADMPANMDKH HHHHHHHCCCCCCHH	2.64	21406390
21	Ubiquitination	DMPANMDKHALKKYR HCCCCCCHHHHHHHH	21.73	-
26	Acetylation	MDKHALKKYRREAYH CCHHHHHHHHHHHHH	44.85	30590925
32	Phosphorylation	KKYRREAYHRVFVNR HHHHHHHHHHHHCCH	5.84	-
55	Phosphorylation	CFGFDMDYTLAVYKS EEEECCEEEEEEEEC	9.30	26074081
56	Phosphorylation	FGFDMDYTLAVYKSP EEECCEEEEEEEECC	12.18	26074081
60	Phosphorylation	MDYTLAVYKSPEYES CEEEEEEEECCCCHH	10.51	20068231
62	Phosphorylation	YTLAVYKSPEYESLG EEEEEEECCCCHHCC	12.79	26074081
65	Phosphorylation	AVYKSPEYESLGFEL EEEECCCCHHCCEEE	17.75	26074081
67	Phosphorylation	YKSPEYESLGFELTV EECCCCHHCCEEEEH	32.65	26074081
73	Phosphorylation	ESLGFELTVERLVSI HHCCEEEEHHHHHHC	17.08	26074081
79	Phosphorylation	LTVERLVSIGYPQEL EEHHHHHHCCCCHHH	18.19	26074081
82	Phosphorylation	ERLVSIGYPQELLSF HHHHHCCCCHHHHHH	10.48	26074081
111	Ubiquitination	TLYGNLLKVDAYGNL HHCCCEEEEECCCCE	41.03	-
115	Phosphorylation	NLLKVDAYGNLLVCA CEEEEECCCCEEEEE	11.33	28442448
137	Phosphorylation	GPETREQYPNKFIQR CCCCHHHCCCCEECC	12.20	23898821
140	Acetylation	TREQYPNKFIQRDDT CHHHCCCCEECCCCH	39.06	25953088
140	Malonylation	TREQYPNKFIQRDDT CHHHCCCCEECCCCH	39.06	26320211
140	Ubiquitination	TREQYPNKFIQRDDT CHHHCCCCEECCCCH	39.06	21890473
147	Phosphorylation	KFIQRDDTERFYILN CEECCCCHHCEEHHH	33.09	23898821
157	Ubiquitination	FYILNTLFNLPETYL EEHHHHHCCCCHHHH	9.21	-
178	Phosphorylation	FFTNCPRYTSCETGF HHHCCCCCCCCCCCC	6.53	-
182	Ubiquitination	CPRYTSCETGFKDGD CCCCCCCCCCCCCCC	52.30	21890473
186	Ubiquitination	TSCETGFKDGDLFMS CCCCCCCCCCCEEEE	63.25	-
186	Ubiquitination	TSCETGFKDGDLFMS CCCCCCCCCCCEEEE	63.25	-
186	Acetylation	TSCETGFKDGDLFMS CCCCCCCCCCCEEEE	63.25	25953088
188	Ubiquitination	CETGFKDGDLFMSYR CCCCCCCCCEEEEHH	33.83	-
193	Phosphorylation	KDGDLFMSYRSMFQD CCCCEEEEHHHHHHH	15.29	-
199	Ubiquitination	MSYRSMFQDVRDAVD EEHHHHHHHHHHHHH	39.38	-
202	Ubiquitination	RSMFQDVRDAVDWVH HHHHHHHHHHHHHHH	34.16	21890473
211	Malonylation	AVDWVHYKGSLKEKT HHHHHHHCCCCCCHH	27.44	26320211
211	Ubiquitination	AVDWVHYKGSLKEKT HHHHHHHCCCCCCHH	27.44	21890473
211	Acetylation	AVDWVHYKGSLKEKT HHHHHHHCCCCCCHH	27.44	25953088
211	Ubiquitination	AVDWVHYKGSLKEKT HHHHHHHCCCCCCHH	27.44	21890473
215	Ubiquitination	VHYKGSLKEKTVENL HHHCCCCCCHHHHHH	59.88	-
215	Ubiquitination	VHYKGSLKEKTVENL HHHCCCCCCHHHHHH	59.88	-
217	Ubiquitination	YKGSLKEKTVENLEK HCCCCCCHHHHHHHH	57.17	-
224	Ubiquitination	KTVENLEKYVVKDGK HHHHHHHHHHCCCCC	46.65	-
225	Ubiquitination	TVENLEKYVVKDGKL HHHHHHHHHCCCCCH	10.91	-
228	Ubiquitination	NLEKYVVKDGKLPLL HHHHHHCCCCCHHHH	51.20	-
231	Ubiquitination	KYVVKDGKLPLLLSR HHHCCCCCHHHHHHH	58.00	21890473
237	Phosphorylation	GKLPLLLSRMKEVGK CCHHHHHHHHHHHCC	30.23	21406692
244	Ubiquitination	SRMKEVGKVFLATNS HHHHHHCCEEEECCC	34.68	21890473
254	Ubiquitination	LATNSDYKYTDKIMT EECCCCCCCCCCHHH	46.82	21890473
254	Acetylation	LATNSDYKYTDKIMT EECCCCCCCCCCHHH	46.82	25953088
263	Ubiquitination	TDKIMTYLFDFPHGP CCCHHHHHHCCCCCC	2.15	-
292	Ubiquitination	LILVDARKPLFFGEG EEEEECCCCCEECCC	48.03	-
313	Ubiquitination	DTKTGKLKIGTYTGP ECCCCEEEEEEECCC	42.44	-
313	Ubiquitination	DTKTGKLKIGTYTGP ECCCCEEEEEEECCC	42.44	-
315	Ubiquitination	KTGKLKIGTYTGPLQ CCCEEEEEEECCCCC	15.87	21890473
330	Ubiquitination	HGIVYSGGSSDTICD CEEEECCCCCHHHHH	20.31	21890473
342	Ubiquitination	ICDLLGAKGKDILYI HHHHHCCCCCCEEEE	65.77	-
344	Ubiquitination	DLLGAKGKDILYIGD HHHCCCCCCEEEEEC	40.67	21890473
359	Ubiquitination	HIFGDILKSKKRQGW HHHHHHHHHCCCCCC	61.64	21890473
408	Phosphorylation	ELYKHLDSSSNERPD HHHHHHCCCCCCCCC	41.86	25627689
409	Phosphorylation	LYKHLDSSSNERPDI HHHHHCCCCCCCCCH	36.53	25627689
410	Phosphorylation	YKHLDSSSNERPDIS HHHHCCCCCCCCCHH	46.81	-
417	Phosphorylation	SNERPDISSIQRRIK CCCCCCHHHHHHHHH	28.86	25159151
418	Phosphorylation	NERPDISSIQRRIKK CCCCCHHHHHHHHHH	24.07	25159151
427	Phosphorylation	QRRIKKVTHDMDMCY HHHHHHHHCCHHHHH	22.49	24043423
434	Phosphorylation	THDMDMCYGMMGSLF HCCHHHHHHHHHHHH	11.04	24043423
439	Phosphorylation	MCYGMMGSLFRSGSR HHHHHHHHHHCCCCH	13.36	24043423
486	Ubiquitination	AAHVLMPHESTVEHT HHHHHCCCCCCCEEE	27.89	21890473
488	Phosphorylation	HVLMPHESTVEHTHV HHHCCCCCCCEEEEE	34.42	20068231
489	Phosphorylation	VLMPHESTVEHTHVD HHCCCCCCCEEEEEC	27.25	20068231
491	Ubiquitination	MPHESTVEHTHVDIN CCCCCCCEEEEECHH	43.06	-
493	Phosphorylation	HESTVEHTHVDINEM CCCCCEEEEECHHHC	15.30	20068231
502	Phosphorylation	VDINEMESPLATRNR ECHHHCCCCCCCCCC	24.73	26055452
506	Phosphorylation	EMESPLATRNRTSVD HCCCCCCCCCCCCCC	35.84	20068231
510	Phosphorylation	PLATRNRTSVDFKDT CCCCCCCCCCCCCCC	36.33	23401153
511	Phosphorylation	LATRNRTSVDFKDTD CCCCCCCCCCCCCCH	19.22	28355574
515	Ubiquitination	NRTSVDFKDTDYKRH CCCCCCCCCCHHHHH	56.08	2190698
517	Phosphorylation	TSVDFKDTDYKRHQL CCCCCCCCHHHHHCC	41.65	28555341
519	Phosphorylation	VDFKDTDYKRHQLTR CCCCCCHHHHHCCHH	16.41	-
520	Ubiquitination	DFKDTDYKRHQLTRS CCCCCHHHHHCCHHC	46.33	-
527	Phosphorylation	KRHQLTRSISEIKPP HHHCCHHCHHHCCCC	25.82	20058876
529	Phosphorylation	HQLTRSISEIKPPNL HCCHHCHHHCCCCCC	34.22	25159151
532	Ubiquitination	TRSISEIKPPNLFPL HHCHHHCCCCCCCCC	50.82	-
545	Phosphorylation	PLAPQEITHCHDEDD CCCCCCCCCCCCCCC	20.07	26330541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of 5NTC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of 5NTC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 5NTC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUD18_HUMAN	NUDT18	physical	16189514
NDK7_HUMAN	NME7	physical	16189514
5NTC_HUMAN	NT5C2	physical	16189514
MOB3B_HUMAN	MOB3B	physical	16189514
NOC4L_HUMAN	NOC4L	physical	16189514
GNPI1_HUMAN	GNPDA1	physical	22863883
HERC4_HUMAN	HERC4	physical	22863883
RD23A_HUMAN	RAD23A	physical	22863883
UBP5_HUMAN	USP5	physical	22863883
SYWC_HUMAN	WARS	physical	22863883
5NTC_HUMAN	NT5C2	physical	25416956
NDK7_HUMAN	NME7	physical	25416956
MOB1B_HUMAN	MOB1B	physical	25416956
MOB3C_HUMAN	MOB3C	physical	25416956
TEBP_HUMAN	PTGES3	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613162	Spastic paraplegia 45, autosomal recessive (SPG45)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00171	Adenosine triphosphate
DB00811	Ribavirin

Regulatory Network of 5NTC_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, AND MASSSPECTROMETRY.	18669648 [Abstract]