| UniProt ID | ZFY21_HUMAN | |
|---|---|---|
| UniProt AC | Q9BQ24 | |
| Protein Name | Zinc finger FYVE domain-containing protein 21 | |
| Gene Name | ZFYVE21 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 234 | |
| Subcellular Localization | Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker. | |
| Protein Description | Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.. | |
| Protein Sequence | MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKECRRCMQCDAKFDFLTRKHHCRRCGKCFCDRCCSQKVPLRRMCFVDPVRQCAECALVSLKEAEFYDKQLKVLLSGATFLVTFGNSEKPETMTCRLSNNQRYLFLDGDSHYEIEIVHISTVQILTEGFPPGGGNARATGMFLQYTVPGTEGVTQLKLTVVEDVTVGRRQAVAWLVAMHKAAKLLYESRDQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MSSEVSARRD -----CCHHHHHHHH | 40.49 | - | |
| 6 | Phosphorylation | --MSSEVSARRDAKK --CCHHHHHHHHHHH | 16.41 | 29083192 | |
| 17 | Phosphorylation | DAKKLVRSPSGLRMV HHHHHHCCCCCCCCC | 18.88 | 25159151 | |
| 19 | Phosphorylation | KKLVRSPSGLRMVPE HHHHCCCCCCCCCCC | 52.27 | 26699800 | |
| 32 | Phosphorylation | PEHRAFGSPFGLEEP CCCCCCCCCCCCCCC | 15.59 | 25849741 | |
| 45 | Ubiquitination | EPQWVPDKECRRCMQ CCCCCCCHHHHHHHC | 53.28 | 29967540 | |
| 105 | Ubiquitination | ECALVSLKEAEFYDK HHHHHEHHHHHHHHH | 47.58 | 32015554 | |
| 182 | Phosphorylation | GGGNARATGMFLQYT CCCCCCCEEEEEEEE | 24.51 | 27642862 | |
| 182 (in isoform 2) | Phosphorylation | - | 24.51 | 28674419 | |
| 183 (in isoform 2) | Phosphorylation | - | 12.12 | 29978859 | |
| 184 | Phosphorylation | GNARATGMFLQYTVP CCCCCEEEEEEEECC | 2.35 | 27642862 | |
| 184 (in isoform 2) | Phosphorylation | - | 2.35 | 28674419 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZFY21_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZFY21_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZFY21_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| REEP6_HUMAN | REEP6 | physical | 25416956 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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