| UniProt ID | SNX10_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5X0 | |
| Protein Name | Sorting nexin-10 | |
| Gene Name | SNX10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 201 | |
| Subcellular Localization |
Cytoplasm. Endosome membrane Peripheral membrane protein Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. May also localize to nucleus and endoplasmic reticulum. |
|
| Protein Description | Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.. | |
| Protein Sequence | MFPEQQKEEFVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDIEACVSGQTKYSVEEAIHKFALMNRRFPEEDEEGKKENDIDYDSESSSSGLGHSSDDSSSHGCKVNTAPQES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Phosphorylation | QKEDFWHSYIDYEIC CCHHHHHHHCCEEEE | 17.87 | 24275569 | |
| 32 | Phosphorylation | FWHSYIDYEICIHTN HHHHHCCEEEEEECC | 9.53 | 24275569 | |
| 38 | Phosphorylation | DYEICIHTNSMCFTM CEEEEEECCCEEEEE | 14.74 | 24275569 | |
| 44 | Phosphorylation | HTNSMCFTMKTSCVR ECCCEEEEECHHHHH | 16.90 | 24275569 | |
| 54 | Phosphorylation | TSCVRRRYREFVWLR HHHHHHHHHHHHHHH | 16.81 | 24275569 | |
| 78 | Phosphorylation | VQLPELPSKNLFFNM EECCCCCCCCEEECC | 46.96 | 24719451 | |
| 79 | Ubiquitination | QLPELPSKNLFFNMN ECCCCCCCCEEECCC | 56.59 | 21890473 | |
| 140 | Phosphorylation | CVSGQTKYSVEEAIH HHCCCCCCCHHHHHH | 22.72 | 24719451 | |
| 141 | Phosphorylation | VSGQTKYSVEEAIHK HCCCCCCCHHHHHHH | 25.30 | 24719451 | |
| 148 | Ubiquitination | SVEEAIHKFALMNRR CHHHHHHHHHHHHCC | 26.64 | 21890473 | |
| 171 | Phosphorylation | KKENDIDYDSESSSS CCCCCCCCCCCCCCC | 23.00 | 26074081 | |
| 173 | Phosphorylation | ENDIDYDSESSSSGL CCCCCCCCCCCCCCC | 32.90 | 23898821 | |
| 175 | Phosphorylation | DIDYDSESSSSGLGH CCCCCCCCCCCCCCC | 39.20 | 30576142 | |
| 176 | Phosphorylation | IDYDSESSSSGLGHS CCCCCCCCCCCCCCC | 25.19 | 23898821 | |
| 177 | Phosphorylation | DYDSESSSSGLGHSS CCCCCCCCCCCCCCC | 37.39 | 23898821 | |
| 178 | Phosphorylation | YDSESSSSGLGHSSD CCCCCCCCCCCCCCC | 39.73 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SNX10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SNX10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNX10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SNX10_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615085 | Osteopetrosis, autosomal recessive 8 (OPTB8) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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