MUCEN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MUCEN_HUMAN
• UniProt AC: Q9ULC0
• Protein Name: Endomucin
• Gene Name: EMCN
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.; Isoform 2: Secreted .
• Protein Description: Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix..
• Protein Sequence: MELLQVTILFLLPSICSSNSTGVLEAANNSLVVTTTKPSITTPNTESLQKNVVTPTTGTTPKGTITNELLKMSLMSTATFLTSKDEGLKATTTDVRKNDSIISNVTVTSVTLPNAVSTLQSSKPKTETQSSIKTTEIPGSVLQPDASPSKTGTLTSIPVTIPENTSQSQVIGTEGGKNASTSATSRSYSSIILPVVIALIVITLSVFVLVGLYRMCWKADPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MELLQVTILFLLPS -CCHHHHHHHHHHHH	10.05	22210691
14	Phosphorylation	TILFLLPSICSSNST HHHHHHHHHHCCCCC	35.88	22210691
19	N-linked_Glycosylation	LPSICSSNSTGVLEA HHHHHCCCCCCHHHH	27.57	UniProtKB CARBOHYD
28	N-linked_Glycosylation	TGVLEAANNSLVVTT CCHHHHCCCCEEEEE	45.75	UniProtKB CARBOHYD
36	Phosphorylation	NSLVVTTTKPSITTP CCEEEEECCCCCCCC	31.43	22210691
64	O-linked_Glycosylation	TGTTPKGTITNELLK CCCCCCCCHHHHHHH	30.65	OGP
76	O-linked_Glycosylation	LLKMSLMSTATFLTS HHHHHHHHHHHHHCC	21.86	OGP
76	Phosphorylation	LLKMSLMSTATFLTS HHHHHHHHHHHHHCC	21.86	-
77	O-linked_Glycosylation	LKMSLMSTATFLTSK HHHHHHHHHHHHCCC	18.76	OGP
84	Acetylation	TATFLTSKDEGLKAT HHHHHCCCCCCCCEE	55.34	7676631
89	Acetylation	TSKDEGLKATTTDVR CCCCCCCCEECCCHH	55.32	7676639
98	N-linked_Glycosylation	TTTDVRKNDSIISNV ECCCHHHCCCCEECE	37.38	UniProtKB CARBOHYD
100	Phosphorylation	TDVRKNDSIISNVTV CCHHHCCCCEECEEE	31.08	22210691
104	N-linked_Glycosylation	KNDSIISNVTVTSVT HCCCCEECEEEEEEE	24.07	UniProtKB CARBOHYD
111	Phosphorylation	NVTVTSVTLPNAVST CEEEEEEECCCHHHH	35.94	22210691
118	O-linked_Glycosylation	TLPNAVSTLQSSKPK ECCCHHHHHHCCCCC	23.40	OGP
118	Phosphorylation	TLPNAVSTLQSSKPK ECCCHHHHHHCCCCC	23.40	22210691
126 (in isoform 3)	Phosphorylation	-	53.44	24043423
127 (in isoform 3)	Phosphorylation	-	51.48	24043423
134	O-linked_Glycosylation	ETQSSIKTTEIPGSV CCCCCCEEEECCCCC	28.17	OGP
134 (in isoform 3)	Phosphorylation	-	28.17	24043423
135	O-linked_Glycosylation	TQSSIKTTEIPGSVL CCCCCEEEECCCCCC	27.24	OGP
136 (in isoform 3)	Phosphorylation	-	53.04	24043423
138 (in isoform 3)	Phosphorylation	-	23.83	24043423
140	O-linked_Glycosylation	KTTEIPGSVLQPDAS EEEECCCCCCCCCCC	17.82	OGP
140 (in isoform 3)	Phosphorylation	-	17.82	24043423
142 (in isoform 3)	Phosphorylation	-	7.01	24043423
143 (in isoform 3)	Phosphorylation	-	31.50	24043423
147 (in isoform 3)	Phosphorylation	-	36.77	24043423
152 (in isoform 3)	Phosphorylation	-	23.59	24043423
153 (in isoform 3)	Phosphorylation	-	31.90	24043423
155 (in isoform 3)	Phosphorylation	-	25.17	24043423
155	O-linked_Glycosylation	PSKTGTLTSIPVTIP CCCCCEEEEEEEECC	25.17	OGP
160 (in isoform 3)	Phosphorylation	-	26.01	24043423
164	N-linked_Glycosylation	IPVTIPENTSQSQVI EEEECCCCCCCCEEE	39.41	UniProtKB CARBOHYD
165	O-linked_Glycosylation	PVTIPENTSQSQVIG EEECCCCCCCCEEEE	26.87	OGP
166	O-linked_Glycosylation	VTIPENTSQSQVIGT EECCCCCCCCEEEEE	39.14	OGP
168	O-linked_Glycosylation	IPENTSQSQVIGTEG CCCCCCCCEEEEECC	26.61	OGP
173	Phosphorylation	SQSQVIGTEGGKNAS CCCEEEEECCCCCCC	21.97	-
178	N-linked_Glycosylation	IGTEGGKNASTSATS EEECCCCCCCCCCCC	42.26	UniProtKB CARBOHYD
180	Phosphorylation	TEGGKNASTSATSRS ECCCCCCCCCCCCCC	32.08	-
181	Phosphorylation	EGGKNASTSATSRSY CCCCCCCCCCCCCCH	21.70	-
182	Phosphorylation	GGKNASTSATSRSYS CCCCCCCCCCCCCHH	27.36	-
223	Phosphorylation	CWKADPGTPENGNDQ HHCCCCCCCCCCCCC	32.58	24702127
233	Phosphorylation	NGNDQPQSDKESVKL CCCCCCCCCHHHEEE	58.28	28857561
237	Phosphorylation	QPQSDKESVKLLTVK CCCCCHHHEEEEEEE	30.23	26657352
242	Phosphorylation	KESVKLLTVKTISHE HHHEEEEEEEEECCC	30.32	28857561
245	Phosphorylation	VKLLTVKTISHESGE EEEEEEEEECCCCCC	24.31	28857561
247	Phosphorylation	LLTVKTISHESGEHS EEEEEEECCCCCCCC	26.83	28857561
250	Phosphorylation	VKTISHESGEHSAQG EEEECCCCCCCCCCC	44.02	28857561
254	Phosphorylation	SHESGEHSAQGKTKN CCCCCCCCCCCCCCC	20.27	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MUCEN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MUCEN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MUCEN_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MUCEN_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.