dbPTM

TENS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TENS1_HUMAN
UniProt AC	Q9HBL0
Protein Name	Tensin-1
Gene Name	TNS1
Organism	Homo sapiens (Human).
Sequence Length	1735
Subcellular Localization	Cell surface . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
Protein Description	Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton..
Protein Sequence	MSVSRTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFSGHRDDGMEEVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTLSATPNHVEHTLSVSSDSGNSTASTKTDKTDEPVPGASSATAALSPQEKRELDRLLSGFGLEREKQGAMYHTQHLRSRPAGGSAVPSSGRHVVPAQVHVNGGALASERETDILDDELPNQDGHSAGSMGTLSSLDGVTNTSEGGYPEALSPLTNGLDKSYPMEPMVNGGGYPYESASRAGPAHAGHTAPMRPSYSAQEGLAGYQREGPHPAWPQPVTTSHYAHDPSGMFRSQSFSEAEPQLPPAPVRGGSSREAVQRGLNSWQQQQQQQQQPRPPPRQQERAHLESLVASRPSPQPLAETPIPSLPEFPRAASQQEIEQSIETLNMLMLDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLSGSSRQSHPLTQSRSGYIPSGHSLGTPEPAPRASLESVPPGRSYSPYDYQPCLAGPNQDFHSKSPASSSLPAFLPTTHSPPGPQQPPASLPGLTAQPLLSPKEATSDPSRTPEEEPLNLEGLVAHRVAGVQAREKQPAEPPAPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPTGVTRRRIQPEEDEGKVVVRLSEEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNKVATTPGSPSLGRHPGAHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLNAGQKR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVSRTMED ------CCCCCCHHH	39.85	-
4	Phosphorylation	----MSVSRTMEDSC ----CCCCCCHHHCC	31.18	24719451
21 (in isoform 2)	Phosphorylation	-	19.08	26657352
68	Phosphorylation	SERRPDITKLHAKVL CCCCCCCHHHHHHHH	34.63	-
69	Ubiquitination	ERRPDITKLHAKVLE CCCCCCHHHHHHHHH	38.31	-
84	Phosphorylation	FGWPDLHTPALEKIC HCCCCCCCHHHHHHH	19.97	-
92	Phosphorylation	PALEKICSICKAMDT HHHHHHHHHHHHHHH	34.20	-
161	Phosphorylation	IVPIGQPSQRRYVHY EEECCCHHHHHHHHH	28.56	28857561
168	Phosphorylation	SQRRYVHYFSGLLSG HHHHHHHHHCCHHHC	6.87	22817900
170	Phosphorylation	RRYVHYFSGLLSGSI HHHHHHHCCHHHCCC	22.74	28857561
174	Phosphorylation	HYFSGLLSGSIKMNN HHHCCHHHCCCCCCC	35.22	27251275
176	Phosphorylation	FSGLLSGSIKMNNKP HCCHHHCCCCCCCCC	18.70	28857561
210	Phosphorylation	CRPFLRIYQAMQPVY CHHHHHHHHHCCCCE	5.47	-
217	Phosphorylation	YQAMQPVYTSGIYNI HHHCCCCEECCCCCC	11.24	-
249	Ubiquitination	LKGDILLKCYHKKFR ECCCEEHHHHHHHCC	29.33	-
257	Phosphorylation	CYHKKFRSPARDVIF HHHHHCCCCCHHHHE	26.50	-
290	Ubiquitination	EDLDDAFKDDRFPEY CHHCHHHCCCCCCCC	61.51	-
327	Phosphorylation	GPSVSVDYNTSDPLI CCEEEECCCCCCCCC	20.41	22817900
329	Phosphorylation	SVSVDYNTSDPLIRW EEEECCCCCCCCCCC	28.42	-
330	Phosphorylation	VSVDYNTSDPLIRWD EEECCCCCCCCCCCC	33.33	-
338	Phosphorylation	DPLIRWDSYDNFSGH CCCCCCCCCCCCCCC	27.68	21082442
339	Phosphorylation	PLIRWDSYDNFSGHR CCCCCCCCCCCCCCC	16.66	18180459
343	Phosphorylation	WDSYDNFSGHRDDGM CCCCCCCCCCCCCCH	39.69	28857561
357	Phosphorylation	MEEVVGHTQGPLDGS HHHHCCCCCCCCCCC	29.32	26356563
364	Phosphorylation	TQGPLDGSLYAKVKK CCCCCCCCEEEEEEC	20.20	26657352
366	Phosphorylation	GPLDGSLYAKVKKKD CCCCCCEEEEEECCC	13.18	21082442
369 (in isoform 2)	Phosphorylation	-	9.28	29116813
370 (in isoform 2)	Phosphorylation	-	54.09	29116813
374	Phosphorylation	AKVKKKDSLHGSTGA EEEECCCCCCCCCCC	31.01	26657352
378	Phosphorylation	KKDSLHGSTGAVNAT CCCCCCCCCCCCCCC	16.96	26657352
379	Phosphorylation	KDSLHGSTGAVNATR CCCCCCCCCCCCCCC	33.48	26657352
385	Phosphorylation	STGAVNATRPTLSAT CCCCCCCCCCCCCCC	31.79	28857561
388	Phosphorylation	AVNATRPTLSATPNH CCCCCCCCCCCCCCC	30.01	28857561
390	Phosphorylation	NATRPTLSATPNHVE CCCCCCCCCCCCCEE	32.35	28857561
392	Phosphorylation	TRPTLSATPNHVEHT CCCCCCCCCCCEEEE	22.65	28857561
399	Phosphorylation	TPNHVEHTLSVSSDS CCCCEEEEEEECCCC	13.76	26657352
401	Phosphorylation	NHVEHTLSVSSDSGN CCEEEEEEECCCCCC	22.55	23312004
403	Phosphorylation	VEHTLSVSSDSGNST EEEEEEECCCCCCCC	25.67	26657352
404	Phosphorylation	EHTLSVSSDSGNSTA EEEEEECCCCCCCCC	33.37	28857561
406	Phosphorylation	TLSVSSDSGNSTAST EEEECCCCCCCCCCC	41.65	28857561
409	Phosphorylation	VSSDSGNSTASTKTD ECCCCCCCCCCCCCC	28.95	23312004
418	Phosphorylation	ASTKTDKTDEPVPGA CCCCCCCCCCCCCCC	48.70	29396449
426	Phosphorylation	DEPVPGASSATAALS CCCCCCCCHHHCCCC	26.81	29396449
427	Phosphorylation	EPVPGASSATAALSP CCCCCCCHHHCCCCH	29.16	29396449
429	Phosphorylation	VPGASSATAALSPQE CCCCCHHHCCCCHHH	17.89	29396449
433	Phosphorylation	SSATAALSPQEKREL CHHHCCCCHHHHHHH	21.58	28355574
437	Ubiquitination	AALSPQEKRELDRLL CCCCHHHHHHHHHHH	46.02	-
445	Phosphorylation	RELDRLLSGFGLERE HHHHHHHHHCCCHHH	36.35	22617229
458	Phosphorylation	REKQGAMYHTQHLRS HHHCCCCEECHHHHC	10.94	26356563
460	Phosphorylation	KQGAMYHTQHLRSRP HCCCCEECHHHHCCC	10.53	26356563
465	Phosphorylation	YHTQHLRSRPAGGSA EECHHHHCCCCCCCC	49.31	23312004
471	Phosphorylation	RSRPAGGSAVPSSGR HCCCCCCCCCCCCCC	25.77	23312004
475	Phosphorylation	AGGSAVPSSGRHVVP CCCCCCCCCCCEEEE	38.53	23312004
476	Phosphorylation	GGSAVPSSGRHVVPA CCCCCCCCCCEEEEE	33.50	23312004
494	Phosphorylation	VNGGALASERETDIL ECCCCCCCHHCCCCC	37.73	24719451
498	Phosphorylation	ALASERETDILDDEL CCCCHHCCCCCCCCC	34.26	24275569
512	Phosphorylation	LPNQDGHSAGSMGTL CCCCCCCCCCCCCCH	39.59	24275569
518	Phosphorylation	HSAGSMGTLSSLDGV CCCCCCCCHHHCCCC	18.15	24275569
520	Phosphorylation	AGSMGTLSSLDGVTN CCCCCCHHHCCCCCC	28.79	24275569
538	Phosphorylation	GGYPEALSPLTNGLD CCCCHHHCCCCCCCC	25.55	-
547	Phosphorylation	LTNGLDKSYPMEPMV CCCCCCCCCCCCCCC	33.85	22199227
548	Phosphorylation	TNGLDKSYPMEPMVN CCCCCCCCCCCCCCC	16.61	28555341
561	Phosphorylation	VNGGGYPYESASRAG CCCCCCCCCCCCCCC	17.65	22817900
575	Phosphorylation	GPAHAGHTAPMRPSY CCCCCCCCCCCCCCC	31.38	26657352
581	Phosphorylation	HTAPMRPSYSAQEGL CCCCCCCCCCHHCCC	22.73	26657352
582	Phosphorylation	TAPMRPSYSAQEGLA CCCCCCCCCHHCCCC	15.65	28857561
583	Phosphorylation	APMRPSYSAQEGLAG CCCCCCCCHHCCCCC	28.01	26657352
591	Phosphorylation	AQEGLAGYQREGPHP HHCCCCCCCCCCCCC	9.97	24702127
605	Phosphorylation	PAWPQPVTTSHYAHD CCCCCCCCCCCCCCC	29.30	26356563
606	Phosphorylation	AWPQPVTTSHYAHDP CCCCCCCCCCCCCCC	17.46	26356563
607	Phosphorylation	WPQPVTTSHYAHDPS CCCCCCCCCCCCCCC	12.72	26356563
609	Phosphorylation	QPVTTSHYAHDPSGM CCCCCCCCCCCCCCC	12.85	26356563
614	Phosphorylation	SHYAHDPSGMFRSQS CCCCCCCCCCCCCCC	49.28	26356563
619	Phosphorylation	DPSGMFRSQSFSEAE CCCCCCCCCCHHHCC	20.93	30266825
621	Phosphorylation	SGMFRSQSFSEAEPQ CCCCCCCCHHHCCCC	31.80	23401153
623	Phosphorylation	MFRSQSFSEAEPQLP CCCCCCHHHCCCCCC	40.94	30266825
638	Phosphorylation	PAPVRGGSSREAVQR CCCCCCCCHHHHHHH	29.10	24670416
639	Phosphorylation	APVRGGSSREAVQRG CCCCCCCHHHHHHHH	37.10	27486199
649	Phosphorylation	AVQRGLNSWQQQQQQ HHHHHHHHHHHHHHH	31.16	-
674	Phosphorylation	QERAHLESLVASRPS HHHHHHHHHHHCCCC	34.21	22199227
678	Phosphorylation	HLESLVASRPSPQPL HHHHHHHCCCCCCCC	36.93	22199227
681	Phosphorylation	SLVASRPSPQPLAET HHHHCCCCCCCCCCC	34.75	26055452
688	Phosphorylation	SPQPLAETPIPSLPE CCCCCCCCCCCCCCC	22.40	26657352
692	Phosphorylation	LAETPIPSLPEFPRA CCCCCCCCCCCCCCC	58.22	26657352
701	Phosphorylation	PEFPRAASQQEIEQS CCCCCCCCHHHHHHH	31.26	24043423
708	Phosphorylation	SQQEIEQSIETLNML CHHHHHHHHHHHHHH	15.03	26657352
711	Phosphorylation	EIEQSIETLNMLMLD HHHHHHHHHHHHHHC	23.05	26657352
731	Phosphorylation	AAAPLHKSQSVPGAW HCCCCCCCCCCCCCC	19.55	25072903
733	Phosphorylation	APLHKSQSVPGAWPG CCCCCCCCCCCCCCC	37.05	21082442
742	Phosphorylation	PGAWPGASPLSSQPL CCCCCCCCCCCCCCC	32.08	26657352
746	Phosphorylation	PGASPLSSQPLSGSS CCCCCCCCCCCCCCC	43.42	19060867
750	Phosphorylation	PLSSQPLSGSSRQSH CCCCCCCCCCCCCCC	43.22	24719451
752	Phosphorylation	SSQPLSGSSRQSHPL CCCCCCCCCCCCCCC	20.97	26657352
753	Phosphorylation	SQPLSGSSRQSHPLT CCCCCCCCCCCCCCC	37.55	28857561
756	Phosphorylation	LSGSSRQSHPLTQSR CCCCCCCCCCCCCCC	26.43	26657352
760	Phosphorylation	SRQSHPLTQSRSGYI CCCCCCCCCCCCCCC	29.02	30242111
762	Phosphorylation	QSHPLTQSRSGYIPS CCCCCCCCCCCCCCC	24.15	28857561
764	Phosphorylation	HPLTQSRSGYIPSGH CCCCCCCCCCCCCCC	40.99	23911959
766	Phosphorylation	LTQSRSGYIPSGHSL CCCCCCCCCCCCCCC	15.77	23911959
769	Phosphorylation	SRSGYIPSGHSLGTP CCCCCCCCCCCCCCC	39.31	24972180
772	Phosphorylation	GYIPSGHSLGTPEPA CCCCCCCCCCCCCCC	31.83	26055452
775	Phosphorylation	PSGHSLGTPEPAPRA CCCCCCCCCCCCCCC	29.76	29255136
783	Phosphorylation	PEPAPRASLESVPPG CCCCCCCCCCCCCCC	33.67	26657352
786	Phosphorylation	APRASLESVPPGRSY CCCCCCCCCCCCCCC	45.26	30266825
792	Phosphorylation	ESVPPGRSYSPYDYQ CCCCCCCCCCCCCCC	35.56	24972180
793	Phosphorylation	SVPPGRSYSPYDYQP CCCCCCCCCCCCCCC	16.59	25072903
794	Phosphorylation	VPPGRSYSPYDYQPC CCCCCCCCCCCCCCC	20.45	24972180
796	Phosphorylation	PGRSYSPYDYQPCLA CCCCCCCCCCCCCCC	22.72	21082442
798	Phosphorylation	RSYSPYDYQPCLAGP CCCCCCCCCCCCCCC	14.44	21082442
813	Phosphorylation	NQDFHSKSPASSSLP CCCCCCCCCCHHCCC	28.81	26657352
816	Phosphorylation	FHSKSPASSSLPAFL CCCCCCCHHCCCCCC	24.68	22199227
817	Phosphorylation	HSKSPASSSLPAFLP CCCCCCHHCCCCCCC	37.69	22199227
818	Phosphorylation	SKSPASSSLPAFLPT CCCCCHHCCCCCCCC	35.56	26657352
825	Phosphorylation	SLPAFLPTTHSPPGP CCCCCCCCCCCCCCC	39.01	22199227
826	Phosphorylation	LPAFLPTTHSPPGPQ CCCCCCCCCCCCCCC	20.58	28857561
828	Phosphorylation	AFLPTTHSPPGPQQP CCCCCCCCCCCCCCC	30.60	26657352
838	Phosphorylation	GPQQPPASLPGLTAQ CCCCCCCCCCCCCCC	40.65	26657352
843	Phosphorylation	PASLPGLTAQPLLSP CCCCCCCCCCCCCCH	29.21	26657352
849	Phosphorylation	LTAQPLLSPKEATSD CCCCCCCCHHHCCCC	41.42	22199227
854	Phosphorylation	LLSPKEATSDPSRTP CCCHHHCCCCCCCCC	34.45	30266825
855	Phosphorylation	LSPKEATSDPSRTPE CCHHHCCCCCCCCCC	55.35	30266825
858	Phosphorylation	KEATSDPSRTPEEEP HHCCCCCCCCCCCCC	54.50	30266825
860	Phosphorylation	ATSDPSRTPEEEPLN CCCCCCCCCCCCCCC	39.11	30266825
899	Phosphorylation	PLRRRAASDGQYENQ CCCCHHCCCCCCCCC	41.09	28355574
903	Phosphorylation	RAASDGQYENQSPEA HHCCCCCCCCCCCCC	23.52	23911959
907	Phosphorylation	DGQYENQSPEATSPR CCCCCCCCCCCCCCC	35.97	28355574
911	Phosphorylation	ENQSPEATSPRSPGV CCCCCCCCCCCCCCC	37.29	23911959
912	Phosphorylation	NQSPEATSPRSPGVR CCCCCCCCCCCCCCC	25.93	23911959
915	Phosphorylation	PEATSPRSPGVRSPV CCCCCCCCCCCCCCC	29.41	23911959
920	Phosphorylation	PRSPGVRSPVQCVSP CCCCCCCCCCEECCH	27.32	26657352
926	Phosphorylation	RSPVQCVSPELALTI CCCCEECCHHHHHEE	21.93	26657352
948	Phosphorylation	PKEPHLHSYKEAFEE CCCCCCHHHHHHHHH	44.23	27251275
949	Phosphorylation	KEPHLHSYKEAFEEM CCCCCHHHHHHHHHH	11.33	26657352
959	Phosphorylation	AFEEMEGTSPSSPPP HHHHHCCCCCCCCCC	24.94	30266825
960	Phosphorylation	FEEMEGTSPSSPPPS HHHHCCCCCCCCCCC	33.37	30266825
962	Phosphorylation	EMEGTSPSSPPPSGV HHCCCCCCCCCCCCC	56.07	30266825
963	Phosphorylation	MEGTSPSSPPPSGVR HCCCCCCCCCCCCCC	44.82	30266825
967	Phosphorylation	SPSSPPPSGVRSPPG CCCCCCCCCCCCCCC	56.55	28348404
971	Phosphorylation	PPPSGVRSPPGLAKT CCCCCCCCCCCCCCC	32.80	26055452
978	Phosphorylation	SPPGLAKTPLSALGL CCCCCCCCCHHHCCC	24.69	26425664
981	Phosphorylation	GLAKTPLSALGLKPH CCCCCCHHHCCCCCC	23.74	-
1019	Phosphorylation	GKVVVRLSEEPRSYV CCEEEECCCCCHHHH	29.38	23312004
1024	Phosphorylation	RLSEEPRSYVESVAR ECCCCCHHHHHHHHH	44.22	26657352
1025	Phosphorylation	LSEEPRSYVESVART CCCCCHHHHHHHHHH	14.98	23312004
1028	Phosphorylation	EPRSYVESVARTAVA CCHHHHHHHHHHHHC	15.84	28555341
1042	Phosphorylation	AGPRAQDSEPKSFSA CCCCCCCCCCCCCCC	43.66	26425664
1046	Phosphorylation	AQDSEPKSFSAPATQ CCCCCCCCCCCCCHH	34.84	30266825
1048	Phosphorylation	DSEPKSFSAPATQAY CCCCCCCCCCCHHHC	40.20	30266825
1052	O-linked_Glycosylation	KSFSAPATQAYGHEI CCCCCCCHHHCCCCC	16.81	30379171
1052	Phosphorylation	KSFSAPATQAYGHEI CCCCCCCHHHCCCCC	16.81	30266825
1055	Phosphorylation	SAPATQAYGHEIPLR CCCCHHHCCCCCCCC	14.81	24702127
1065	Phosphorylation	EIPLRNGTLGGSFVS CCCCCCCCCCCCCCC	26.27	27251275
1069	Phosphorylation	RNGTLGGSFVSPSPL CCCCCCCCCCCCCCC	22.22	27251275
1077	Phosphorylation	FVSPSPLSTSSPILS CCCCCCCCCCCCCCC	29.63	27251275
1078	Phosphorylation	VSPSPLSTSSPILSA CCCCCCCCCCCCCCC	40.69	27251275
1079	Phosphorylation	SPSPLSTSSPILSAD CCCCCCCCCCCCCCC	30.64	27251275
1080	Phosphorylation	PSPLSTSSPILSADS CCCCCCCCCCCCCCC	18.95	27251275
1084	Phosphorylation	STSSPILSADSTSVG CCCCCCCCCCCCCCC	30.65	27251275
1087	Phosphorylation	SPILSADSTSVGSFP CCCCCCCCCCCCCCC	23.46	27251275
1088	Phosphorylation	PILSADSTSVGSFPS CCCCCCCCCCCCCCC	28.16	27251275
1089	Phosphorylation	ILSADSTSVGSFPSG CCCCCCCCCCCCCCC	28.56	27251275
1098	Phosphorylation	GSFPSGESSDQGPRT CCCCCCCCCCCCCCC	42.62	26657352
1099	Phosphorylation	SFPSGESSDQGPRTP CCCCCCCCCCCCCCC	29.65	22210691
1105	Phosphorylation	SSDQGPRTPTQPLLE CCCCCCCCCCCCCHH	33.55	30266825
1107	Phosphorylation	DQGPRTPTQPLLESG CCCCCCCCCCCHHCC	42.05	30266825
1113	Phosphorylation	PTQPLLESGFRSGSL CCCCCHHCCCCCCCC	43.11	26657352
1117	Phosphorylation	LLESGFRSGSLGQPS CHHCCCCCCCCCCCC	30.39	26055452
1119	Phosphorylation	ESGFRSGSLGQPSPS HCCCCCCCCCCCCHH	30.49	30266825
1124	Phosphorylation	SGSLGQPSPSAQRNY CCCCCCCCHHHHHCC	24.49	26055452
1126	Phosphorylation	SLGQPSPSAQRNYQS CCCCCCHHHHHCCCC	41.18	30266825
1131	Phosphorylation	SPSAQRNYQSSSPLP CHHHHHCCCCCCCCC	16.38	28450419
1133	Phosphorylation	SAQRNYQSSSPLPTV HHHHCCCCCCCCCCC	23.56	28450419
1134	Phosphorylation	AQRNYQSSSPLPTVG HHHCCCCCCCCCCCC	22.05	28450419
1135	Phosphorylation	QRNYQSSSPLPTVGS HHCCCCCCCCCCCCC	35.39	21082442
1139	Phosphorylation	QSSSPLPTVGSSYSS CCCCCCCCCCCCCCC	45.22	28387310
1142	Phosphorylation	SPLPTVGSSYSSPDY CCCCCCCCCCCCCCC	23.05	28450419
1143	Phosphorylation	PLPTVGSSYSSPDYS CCCCCCCCCCCCCCC	24.09	30576142
1144	Phosphorylation	LPTVGSSYSSPDYSL CCCCCCCCCCCCCCC	18.18	28450419
1145	Phosphorylation	PTVGSSYSSPDYSLQ CCCCCCCCCCCCCCC	37.02	30576142
1146	Phosphorylation	TVGSSYSSPDYSLQH CCCCCCCCCCCCCCC	17.35	30576142
1149	Phosphorylation	SSYSSPDYSLQHFSS CCCCCCCCCCCCCCC	18.05	21082442
1150	Phosphorylation	SYSSPDYSLQHFSSS CCCCCCCCCCCCCCC	29.00	23663014
1155	Phosphorylation	DYSLQHFSSSPESQA CCCCCCCCCCHHHHH	27.99	21082442
1156	Phosphorylation	YSLQHFSSSPESQAR CCCCCCCCCHHHHHH	49.31	23663014
1157	Phosphorylation	SLQHFSSSPESQARA CCCCCCCCHHHHHHH	31.33	19276368
1160	Phosphorylation	HFSSSPESQARAQFS CCCCCHHHHHHHEEE	32.31	21082442
1167	Phosphorylation	SQARAQFSVAGVHTV HHHHHEEEECCEEEC	10.04	26055452
1173	Phosphorylation	FSVAGVHTVPGSPQA EEECCEEECCCCCCC	26.45	30266825
1177	Phosphorylation	GVHTVPGSPQARHRT CEEECCCCCCCCCCC	14.04	22617229
1184	Phosphorylation	SPQARHRTVGTNTPP CCCCCCCCCCCCCCC	19.70	28857561
1187	Phosphorylation	ARHRTVGTNTPPSPG CCCCCCCCCCCCCCC	31.42	30266825
1189	Phosphorylation	HRTVGTNTPPSPGFG CCCCCCCCCCCCCCC	36.09	30266825
1192	Phosphorylation	VGTNTPPSPGFGWRA CCCCCCCCCCCCCCC	38.57	19664994
1208	Phosphorylation	NPSMAAPSSPSLSHH CHHHCCCCCCCCCCC	50.59	27251275
1209	Phosphorylation	PSMAAPSSPSLSHHQ HHHCCCCCCCCCCCC	19.90	32645325
1211	Phosphorylation	MAAPSSPSLSHHQMM HCCCCCCCCCCCCCC	44.44	27251275
1213	Phosphorylation	APSSPSLSHHQMMGP CCCCCCCCCCCCCCC	24.22	27251275
1232	Phosphorylation	FHGSTVSSPQSSAAT CCCCCCCCCCCCCCC	23.71	-
1243	Phosphorylation	SAATTPGSPSLCRHP CCCCCCCCCHHHCCC	16.72	26657352
1245	Phosphorylation	ATTPGSPSLCRHPAG CCCCCCCHHHCCCCC	41.62	26657352
1254	Phosphorylation	CRHPAGVYQVSGLHN HCCCCCEEEEECCCC	11.41	21945579
1257	Phosphorylation	PAGVYQVSGLHNKVA CCCEEEEECCCCCCC	21.80	21945579
1265	Phosphorylation	GLHNKVATTPGSPSL CCCCCCCCCCCCCCC	36.19	27461979
1266	Phosphorylation	LHNKVATTPGSPSLG CCCCCCCCCCCCCCC	18.86	26055452
1269	Phosphorylation	KVATTPGSPSLGRHP CCCCCCCCCCCCCCC	16.72	22617229
1271	Phosphorylation	ATTPGSPSLGRHPGA CCCCCCCCCCCCCCC	45.19	24972180
1285	Phosphorylation	AHQGNLASGLHSNAI CCCCCCCCCCCCCCC	45.08	27174698
1289	Phosphorylation	NLASGLHSNAIASPG CCCCCCCCCCCCCCC	32.76	20068231
1294	Phosphorylation	LHSNAIASPGSPSLG CCCCCCCCCCCCCCC	24.55	30266825
1297	Phosphorylation	NAIASPGSPSLGRHL CCCCCCCCCCCCCCC	18.07	30266825
1299	Phosphorylation	IASPGSPSLGRHLGG CCCCCCCCCCCCCCC	45.19	30266825
1307	Phosphorylation	LGRHLGGSGSVVPGS CCCCCCCCCCCCCCC	26.54	26055452
1309	Phosphorylation	RHLGGSGSVVPGSPC CCCCCCCCCCCCCCC	22.95	24972180
1314	Phosphorylation	SGSVVPGSPCLDRHV CCCCCCCCCCCCCCC	13.33	23401153
1323	Phosphorylation	CLDRHVAYGGYSTPE CCCCCCCCCCCCCCC	15.25	20007894
1326	Phosphorylation	RHVAYGGYSTPEDRR CCCCCCCCCCCCCCC	12.66	21712546
1327	Phosphorylation	HVAYGGYSTPEDRRP CCCCCCCCCCCCCCC	40.54	21082442
1328	Phosphorylation	VAYGGYSTPEDRRPT CCCCCCCCCCCCCCC	23.39	26055452
1335	Phosphorylation	TPEDRRPTLSRQSSA CCCCCCCCCCCCCCC	35.24	28857561
1337	Phosphorylation	EDRRPTLSRQSSASG CCCCCCCCCCCCCCC	30.65	28857561
1340	Phosphorylation	RPTLSRQSSASGYQA CCCCCCCCCCCCCCC	27.11	26657352
1341	Phosphorylation	PTLSRQSSASGYQAP CCCCCCCCCCCCCCC	20.37	26657352
1343	Phosphorylation	LSRQSSASGYQAPST CCCCCCCCCCCCCCC	39.73	26657352
1345	Phosphorylation	RQSSASGYQAPSTPS CCCCCCCCCCCCCCC	10.06	26657352
1349	Phosphorylation	ASGYQAPSTPSFPVS CCCCCCCCCCCCCCC	56.84	26657352
1350	Phosphorylation	SGYQAPSTPSFPVSP CCCCCCCCCCCCCCC	23.15	26657352
1352	Phosphorylation	YQAPSTPSFPVSPAY CCCCCCCCCCCCCCC	42.12	26657352
1356	Phosphorylation	STPSFPVSPAYYPGL CCCCCCCCCCCCCCC	12.21	26657352
1359	Phosphorylation	SFPVSPAYYPGLSSP CCCCCCCCCCCCCCC	17.36	26657352
1360	Phosphorylation	FPVSPAYYPGLSSPA CCCCCCCCCCCCCCC	7.91	28857561
1364	Phosphorylation	PAYYPGLSSPATSPS CCCCCCCCCCCCCCC	39.94	28857561
1365	Phosphorylation	AYYPGLSSPATSPSP CCCCCCCCCCCCCCC	24.48	28857561
1371	Phosphorylation	SSPATSPSPDSAAFR CCCCCCCCCCCHHHH	40.90	26657352
1374	Phosphorylation	ATSPSPDSAAFRQGS CCCCCCCCHHHHCCC	25.53	29802988
1381	Phosphorylation	SAAFRQGSPTPALPE CHHHHCCCCCCCCCC	19.77	29255136
1383	Phosphorylation	AFRQGSPTPALPEKR HHHCCCCCCCCCCHH	23.92	30266825
1393	Phosphorylation	LPEKRRMSVGDRAGS CCCHHCCCCCCCCCC	22.57	24972180
1400	Phosphorylation	SVGDRAGSLPNYATI CCCCCCCCCCCCEEE	39.40	30266825
1404	Phosphorylation	RAGSLPNYATINGKV CCCCCCCCEEECCEE	11.81	30266825
1406	Phosphorylation	GSLPNYATINGKVSS CCCCCCEEECCEECC	12.48	23403867
1412	Phosphorylation	ATINGKVSSPVASGM EEECCEECCCCCCCC	32.20	26657352
1413	Phosphorylation	TINGKVSSPVASGMS EECCEECCCCCCCCC	26.78	28355574
1417	Phosphorylation	KVSSPVASGMSSPSG EECCCCCCCCCCCCC	34.95	21712546
1420	Phosphorylation	SPVASGMSSPSGGST CCCCCCCCCCCCCCC	42.49	22617229
1421	Phosphorylation	PVASGMSSPSGGSTV CCCCCCCCCCCCCCE	17.75	28355574
1423	Phosphorylation	ASGMSSPSGGSTVSF CCCCCCCCCCCCEEE	58.70	26657352
1426	Phosphorylation	MSSPSGGSTVSFSHT CCCCCCCCCEEEEEE	29.21	21712546
1427	Phosphorylation	SSPSGGSTVSFSHTL CCCCCCCCEEEEEEC	24.36	26657352
1429	Phosphorylation	PSGGSTVSFSHTLPD CCCCCCEEEEEECCC	22.56	28450419
1431	Phosphorylation	GGSTVSFSHTLPDFS CCCCEEEEEECCCHH	14.20	26657352
1433	Phosphorylation	STVSFSHTLPDFSKY CCEEEEEECCCHHHC	38.50	28450419
1438	Phosphorylation	SHTLPDFSKYSMPDN EEECCCHHHCCCCCC	37.76	28857561
1440	Phosphorylation	TLPDFSKYSMPDNSP ECCCHHHCCCCCCCH	14.70	29396449
1441	O-linked_Glycosylation	LPDFSKYSMPDNSPE CCCHHHCCCCCCCHH	27.81	30379171
1441	Phosphorylation	LPDFSKYSMPDNSPE CCCHHHCCCCCCCHH	27.81	29396449
1446	Phosphorylation	KYSMPDNSPETRAKV HCCCCCCCHHHHHHE	31.34	23911959
1449	Phosphorylation	MPDNSPETRAKVKFV CCCCCHHHHHHEEEE	39.03	29396449
1454	Ubiquitination	PETRAKVKFVQDTSK HHHHHHEEEEECCCC	38.83	-
1462	Phosphorylation	FVQDTSKYWYKPEIS EEECCCCCCCCCCCC	17.46	-
1490	Phosphorylation	GAFIIRDSHSFRGAY CCEEEECCCCCCCCE	15.93	26657352
1492	Phosphorylation	FIIRDSHSFRGAYGL EEEECCCCCCCCEEE	22.16	25159151
1497	Phosphorylation	SHSFRGAYGLAMKVS CCCCCCCEEEEEEEC	18.59	23663014
1504	Phosphorylation	YGLAMKVSSPPPTIM EEEEEEECCCCCCCC	31.44	23663014
1505	Phosphorylation	GLAMKVSSPPPTIMQ EEEEEECCCCCCCCC	44.40	23663014
1509	Phosphorylation	KVSSPPPTIMQQNKK EECCCCCCCCCCCCC	34.55	23663014
1576	Phosphorylation	VIPNRDPTDESKDSS EECCCCCCCCCCCCC	57.60	26657352
1579	Phosphorylation	NRDPTDESKDSSGPA CCCCCCCCCCCCCCC	44.57	23312004
1580	Ubiquitination	RDPTDESKDSSGPAN CCCCCCCCCCCCCCC	60.63	-
1582	Phosphorylation	PTDESKDSSGPANST CCCCCCCCCCCCCHH	40.71	26657352
1583	Phosphorylation	TDESKDSSGPANSTA CCCCCCCCCCCCHHH	59.95	23403867
1588	Phosphorylation	DSSGPANSTADLLKQ CCCCCCCHHHHHHHH	27.38	11023826
1589	Phosphorylation	SSGPANSTADLLKQG CCCCCCHHHHHHHHC	24.81	23403867
1622	Phosphorylation	PQAISKATSETLAAD HHHHHHHHHCCCCCC	30.72	28857561
1623	Phosphorylation	QAISKATSETLAADP HHHHHHHHCCCCCCC	33.18	28857561
1625	Phosphorylation	ISKATSETLAADPTP HHHHHHCCCCCCCCC	22.82	26657352
1631	Phosphorylation	ETLAADPTPAATIVH CCCCCCCCCCCEEEE	26.55	28857561
1635	Phosphorylation	ADPTPAATIVHFKVS CCCCCCCEEEEEEEE	26.16	23312004
1665	Phosphorylation	RRHYPLNTVTFCDLD EECCCCCCEEEECCC	28.71	-
1667	Phosphorylation	HYPLNTVTFCDLDPQ CCCCCCEEEECCCHH	19.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TENS1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TENS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
1177	Phosphorylation	1184 (7)	W ⇒ R	rs2571445	Pulmonary function Pulmonary function (smoking interaction) Lung function (FEV1) Lung function (FEV1/FVC) Lung function (FVC) Immature fraction of reticulocytes Coronary artery disease High light scatter reticulocyte count High light scatter reticulocyte percentage of red cells Intraocular pressure	20010834 23284291 28166213 27863252 29212778 29617998
1184	Phosphorylation	1184 (0)	W ⇒ R	rs2571445	Pulmonary function Pulmonary function (smoking interaction) Lung function (FEV1) Lung function (FEV1/FVC) Lung function (FVC) Immature fraction of reticulocytes Coronary artery disease High light scatter reticulocyte count High light scatter reticulocyte percentage of red cells Intraocular pressure	20010834 23284291 28166213 27863252 29212778 29617998
1189	Phosphorylation	1184 (5)	W ⇒ R	rs2571445	Pulmonary function Pulmonary function (smoking interaction) Lung function (FEV1) Lung function (FEV1/FVC) Lung function (FVC) Immature fraction of reticulocytes Coronary artery disease High light scatter reticulocyte count High light scatter reticulocyte percentage of red cells Intraocular pressure	20010834 23284291 28166213 27863252 29212778 29617998
1192	Phosphorylation	1184 (8)	W ⇒ R	rs2571445	Pulmonary function Pulmonary function (smoking interaction) Lung function (FEV1) Lung function (FEV1/FVC) Lung function (FVC) Immature fraction of reticulocytes Coronary artery disease High light scatter reticulocyte count High light scatter reticulocyte percentage of red cells Intraocular pressure	20010834 23284291 28166213 27863252 29212778 29617998

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BABA1_HUMAN	BABAM1	physical	27880917
BRCC3_HUMAN	BRCC3	physical	27880917
CSK_HUMAN	CSK	physical	27880917
CTNL1_HUMAN	CTNNAL1	physical	27880917
DMD_HUMAN	DMD	physical	27880917
DTNB_HUMAN	DTNB	physical	27880917
ABRX2_HUMAN	FAM175B	physical	27880917
SNTB1_HUMAN	SNTB1	physical	27880917
SNTB2_HUMAN	SNTB2	physical	27880917
VINEX_HUMAN	SORBS3	physical	27880917
UTRO_HUMAN	UTRN	physical	27880917

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TENS1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445; SER-1177; SER-1192;THR-1266; SER-1269; SER-1381 AND SER-1446, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338; SER-733; SER-746;SER-858; SER-1048; SER-1124; SER-1155; SER-1157; SER-1192; SER-1314;TYR-1326 AND THR-1328, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1107; THR-1189;SER-1192; SER-1269; SER-1314 AND SER-1381, AND MASS SPECTROMETRY.	18088087 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1297, AND MASSSPECTROMETRY.	17081983 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1254; TYR-1323; TYR-1326AND TYR-1404, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-327; TYR-339; TYR-366;TYR-796; TYR-903; TYR-1149; TYR-1323; TYR-1326 AND TYR-1404, AND MASSSPECTROMETRY.	18083107 [Abstract]