HPS6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPS6_HUMAN
• UniProt AC: Q86YV9
• Protein Name: Hermansky-Pudlak syndrome 6 protein
• Gene Name: HPS6
• Organism: Homo sapiens (Human).
• Sequence Length: 775
• Subcellular Localization: Microsome membrane . Cytoplasm, cytosol . Early endosome membrane . Lysosome membrane .
• Protein Description: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. [PubMed: 17041891 Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning]
• Protein Sequence: MKRSGTLRLLSDLSAFGGAARLRELVAGDSAVRVRGSPDGRHLLLLRPPGAVAPQLLVASRGPGAELERAWPAGQPSPLDAFFLPWPARPALVLVWESGLAEVWGAGVGPGWRPLQSTELCPGGGARVVAVAALRGRLVWCEERQARAEGPSGSPAAAFSHCVCVRTLEPSGEASTSLGRTHVLLHHCPAFGLLASCRQLFLVPTATTWPGVAHVLLIWSPGKGKVMVAAPRLGLSYSKSLNPGRGDTWDFRTLLRGLPGLLSPREPLAVHTWAPTPQGLLLLDFGGTVSLLQSHGGTRAVGTLQEAPVGPWGSAALGTFQGTLACVLGSTLELLDMGSGQLLERKVLSTDRVHLLEPPAPGMEDEEELETRGNLRLLSALGLFCVGWEAPQGVELPSAKDLVFEEACGYYQRRSLRGAQLTPEELRHSSTFRAPQALASILQGHLPPSALLTMLRTELRDYRGLEQLKAQLVAGDDEEAGWTELAEQEVARLLRTELIGDQLAQLNTVFQALPTAAWGATLRALQLQLDGNGKLRSQAPPDVWKKVLGGITAGKEPPNGILPPFELLCQCLCQLEPRWLPPFVELAQQQGGPGWGAGGPGLPLYRRALAVLGEEGTRPEALELELLLSSGRPKAVLQAVGQLVQKEQWDRALDAGLALGPSSPLLRSEIFKLLLAEFAQHRRLDAHLPLLCRLCPPELAPAELLLLLRTYLPDEVGPPTPFPEPGAEPPLTVGLLKALLEQTGAQGWLSGPVLSPYEDILWDPSTPPPTPPRDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	SGTLRLLSDLSAFGG CCHHHHHHHHHHCCH	40.89	28857561
14	Phosphorylation	LRLLSDLSAFGGAAR HHHHHHHHHCCHHHH	26.92	20873877
61	Methylation	PQLLVASRGPGAELE CCEEEECCCCCHHHH	45.66	115479661
154	Phosphorylation	RAEGPSGSPAAAFSH HHCCCCCCHHHHHCC	18.72	28555341
225	Malonylation	IWSPGKGKVMVAAPR EECCCCCEEEEEECC	30.55	26320211
225	Ubiquitination	IWSPGKGKVMVAAPR EECCCCCEEEEEECC	30.55	-
236	Phosphorylation	AAPRLGLSYSKSLNP EECCCCEEECCCCCC	26.09	25463755
239	Ubiquitination	RLGLSYSKSLNPGRG CCCEEECCCCCCCCC	51.21	27667366
240	Phosphorylation	LGLSYSKSLNPGRGD CCEEECCCCCCCCCC	27.69	25463755
263	Phosphorylation	RGLPGLLSPREPLAV CCCCCCCCCCCCCEE	27.27	22167270
346	Ubiquitination	SGQLLERKVLSTDRV CCHHEEEEECCCCCE	37.85	21906983
398	Phosphorylation	PQGVELPSAKDLVFE CCCCCCCCHHHHHHH	61.65	24719451
429	Phosphorylation	TPEELRHSSTFRAPQ CHHHHHCCCCCCHHH	25.33	28555341
462	Phosphorylation	LRTELRDYRGLEQLK HHHHHHCCCCHHHHH	10.51	29496907
469	Ubiquitination	YRGLEQLKAQLVAGD CCCHHHHHHHHCCCC	33.51	21906983
534	Ubiquitination	LQLDGNGKLRSQAPP EEECCCCCCCCCCCC	44.73	21906983
545	Ubiquitination	QAPPDVWKKVLGGIT CCCCCHHHHHHCCCC	32.62	21906983
546	Ubiquitination	APPDVWKKVLGGITA CCCCHHHHHHCCCCC	27.29	33845483
555	Sumoylation	LGGITAGKEPPNGIL HCCCCCCCCCCCCCC	65.66	-
646	Ubiquitination	AVGQLVQKEQWDRAL HHHHHHHHHHHHHHH	44.38	21906983
662	Phosphorylation	AGLALGPSSPLLRSE HHCCCCCCCHHHHHH	42.67	27966365
663	Phosphorylation	GLALGPSSPLLRSEI HCCCCCCCHHHHHHH	23.77	20068231
672	Ubiquitination	LLRSEIFKLLLAEFA HHHHHHHHHHHHHHH	43.84	22817900
743	Phosphorylation	LKALLEQTGAQGWLS HHHHHHHHCCCCCCC	25.72	20873877
750	Phosphorylation	TGAQGWLSGPVLSPY HCCCCCCCCCCCCCC	34.24	20873877
755	Phosphorylation	WLSGPVLSPYEDILW CCCCCCCCCCHHHCC	26.18	20873877
757	Phosphorylation	SGPVLSPYEDILWDP CCCCCCCCHHHCCCC	23.90	22199227
765	Phosphorylation	EDILWDPSTPPPTPP HHHCCCCCCCCCCCC	51.58	22199227
766	Phosphorylation	DILWDPSTPPPTPPR HHCCCCCCCCCCCCC	45.24	22199227
770	Phosphorylation	DPSTPPPTPPRDL-- CCCCCCCCCCCCC--	52.26	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPS6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPS6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPS6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HPS5_HUMAN	HPS5	physical	28514442
HPS3_HUMAN	HPS3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00166: Hermansky-Pudlak syndrome (HPS)
• OMIM Disease
• 614075: Hermansky-Pudlak syndrome 6 (HPS6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.